Sentences with phrase «late stage disease»

«Depressed men with prostate cancer are diagnosed with later stage disease, and get less effective therapies.»

With the management of type 2 diabetes and its risk factors (such as obesity and physical inactivity) being simpler and cheaper than treating complications of later stage disease, the researchers note that prevention of disease onset and complications will be crucial to improve health and avoid further economic burden.

Several additional phase 3 trials of apalutamide are currently underway for other prostate cancer disease states, including studies of both earlier and later stage disease.

Not exact matches

Still, more drugs are in late - stage trials that could have an impact on the disease, and researchers are pinning hopes on diagnosing the disease early, before symptoms even show up.

In a late - stage trial, Darzalex combined with Velcade and chemotherapy slashed patients» risk of worsening disease or death by a stunning 61 % compared with the results for Velcade and chemotherapy alone.

The company is also seeking deeper inroads into rare diseases, with a number of assets in late - stage development, and last year it scored a major regulatory win when Europe approved its «bubble boy syndrome» gene therapy Strimvelis.

Acorda said the cost reductions would help the company focus on its two late - stage studies for Parkinson's disease.

Alnylam, which has been weighed down in the past by drug safety concerns, said it plans to initiate a program targeting cardiomyopathy - another symptom of the disease - alongside polyneuropathy in a late - stage study next year.

The detection of melanoma at its most curable stages can result in decades of high - quality life saved, versus the treatment of this terrible disease at late stages, which offers several months of life extension, at best.»

Radiologists came from across the hospital to peer at the results, disbelieving: A perfectly healthy 21 - year - old nonsmoker with no family history of the disease had lung cancer, which three days later would be diagnosed as stage IV, the most advanced form.

The disease was deemed to be in its later stages by a Lyme disease specialist when it was diagnosed, who then recommended a treatment program of intensive antibiotic therapy for several months.

Currently around 20 % of people are diagnosed with bowel cancer as an emergency when outcomes are generally poorer and almost 50 % in later stages of the disease when it is harder to treat.

CAVD progresses rapidly through multiple, distinct stages of disease, but is general diagnosed late, making it challenging to develop targeted treatments.

«Unfortunately, most clinical trials to date have focused on patients whose cognitive deficits are already mild to severe, and when the therapeutic opportunities in this late stage of the disease are minimal.

Genetically reprogramming late - stage human cancer cells to a stem - cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early - stage disease along the way.

Treatment of knee osteoarthritis is shifting focus from end stage treatment to preventing the progression from early to the late stage of the disease, with the specific aim of decreasing the need for joint replacement and other costly treatments.

The Duke medical researchers and ecologists who have joined that project hope to identify which species flourish in early stages of the human microbiome, how they are influenced by the consumption of breast milk, and what role they play in critical diseases affecting infants as well as in chronic diseases that occur later in life.

According to Dr. Xu, nearly 80 percent of pancreatic cancer cases are diagnosed in the late stages of the disease when «cancer is very aggressive and typically spreading throughout the body.»

Alzheimer's is an agonizingly slow process, so by the time we get to study the disease itself during its late stages, all kinds of things have gone on that may be just consequences of disease rather than causal.

«In principle, one could save people suffering from cutaneous late - stage anthrax infections and maybe treat a variety of other similar diseases,» said Bier.

For example, a rexinoid approved for treating certain types of late - stage cancer raises levels of lipids called triglycerides in the blood, which could worsen obesity and cardiovascular disease.

Today New York State and California still rank among the highest in the number of cases, according to the Centers for Disease Control and Prevention, with more than 150,000 people living with AIDS (the later stages of HIV infection) between them.

«These medications are often stopped when patients are in the late, but pre-dialysis, stages of kidney disease because of the risk of dangerously high potassium levels.

R5 viruses are exclusively associated with primary infection, and X4 viruses emerge in later stages of HIV diseases in half of HIV carriers.

An unexpected finding was that many of the innate immunity pathways that were active in the late stages of these inherited blinding diseases were the same as those that are associated with more common vision disorders including diabetic retinopathy and age - related macular degeneration, or AMD.

«Commonalities in late stages of inherited blinding diseases suggest targets for therapy.»

So now, with late - stage clinical failures piling up, the U.S. Food and Drug Administration (FDA) has set off down a path to adapt those standards as researchers are pushed inexorably into earlier and earlier forms of the disease, ahead of the brain damage inflicted by Alzheimer's.

Rather than looking at what distinguished two forms of retinitis pigmentosa, or RP, a progressive blinding disease, they looked for what they had in common: specifically, what genes were expressed at the later stages of disease.

«Although there is a high risk of progression to decompensated cirrhosis and liver cancer among patients with advanced fibrosis, limiting access to people who have already progressed to late - stage disease as compared to treating earlier to prevent these liver - related complications seems counter-intuitive as a public health strategy.»

Their findings, showing the involvement of common immunity - related pathways, point toward potential new strategies for treating the late stages of inherited blinding diseases.

Vtesse is currently running a late - stage clinical trial of the drug, a large sugar molecule known as a cyclodextrin, in which it is injected by lumbar puncture into the spinal fluid of children with the disease (see «Why are people fighting over a promising treatment for a fatal childhood disease»).

However, the researchers found that stopping neurogenesis before the development of seizures had a long - lasting effect, suppressing chronic seizure frequency for nearly one year, even at a late stage of the disease.

«If we could perhaps modulate these pathways and prolong survival of photoreceptor cells, we might be able to delay any further degeneration even when intervening at these later stages of disease.»

«We wanted to identify some potential therapeutic targets that are common not just to one but to multiple forms of retinitis pigmentosa at late - stage disease, when it is more likely to be clinically diagnosed in a patient population.»

A drug used to treat men with late - stage prostate cancer proved effective in stemming progression of the disease in research participants who had not yet received chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led by the Knight Cancer Institute at Oregon Health & Science University (OHSU).

Trial participants have advanced disease with geography atrophy — considered a late stage in dry AMD — and very poor visual abilities.

During the later stages of the disease, patients experience seizures, become wheelchair bound and can have trouble swallowing.

The next step, Akassoglou says, is to determine the role p75NTR plays in later stages of liver disease, to see if shutting it down will stop the harmful production of collagen.

Researchers are also searching for early detection methods for ovarian cancer, a disease that's often caught in very late stages.

Breast cancer cells that spread to other parts of the body break off and leave the primary tumour at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found.

They had thought that falls tended to occur during later stages of the disease.

«Many of the diseases associated with childhood abuse typically emerge in middle and later stages of adulthood — decades after the abuse actually occurred,» said Chiang, a postdoctoral fellow with Northwestern's Foundations of Health Research Center and its Institute for Policy Research.

Pancreatic cancer is a particularly devastating disease because of the difficulty of identifying it at an early stage, and the difficulty of treating it when discovered at a late stage.

Is the reduced amount of this protein a risk factor, or a feature of the later stages of the disease?

To date, no licensed drugs have shown a convincing impact on this later stage of the disease.

But while this approach is good at diagnosing the disease at later stages, it can miss the disease early on when antibody levels are low.

Its levels declined again in late - stage patients with full dementia, closely mirroring the pattern of microglia activity during the course of the disease.

When these motor neurons die, the brain can no longer control muscle movements; in the later stages of the disease, patients become totally paralyzed.

«Early stage disease is curable,» adds co-author Bernadette Cracchiolo, director of gynecologic oncology at the school, «but late stage and recurrent disease have limited treatment options.

Professor Sinclair said: «It is well established that prior to conception and in the early stages of pregnancy during natural or assisted reproduction subtle chemical changes can affect the human genome leading to development and late - onset chronic diseases.