Sentences with phrase «latency reactivation»
Therapeutic vaccination targeting conserved regions of HIV - 1 combined with HIV latency reactivation strategies may facilitate clearance of the viral reservoir in early - treated individuals.
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In healthy individuals HCMV establishes lifelong latency, but in immunocompromised patients, viral reactivation can lead to severe clinical symptoms, such as disseminated viral infection, blindness and potentially cancer.
«While HIV - 1 latency is likely to be a multifactorial process, we have shown that inhibiting the methylation of the provirus contributes to an almost complete reactivation of latent HIV - 1,» said lead author Steven E. Kauder.
They also discovered that the latency type and levels of spontaneous reactivation indicated how effectively chemotherapy drugs reactivated the virus.
James S, Mahalingam R, Gilden D. Does apoptosis play a role in varicella zoster virus latency and reactivation?
Established a Jurkat cell model of HIV latency (5A8 cells) that is inducible by T - cell receptor cross-linking and displays drug reactivation profiles resembling that from resting CD4 T cells from aviremic patients.
Latency will develop in approximately eighty percent of infected cats and approximately fifty percent of latently infected cats will have spontaneous and stress - related reactivation and shedding of the virus.