Sentences with phrase «latency reversing»
The team believes pairing a latency reversing agent, like Vorinostat, with an antiviral immune therapy, such as a vaccine or an antibody capable of recognizing and clearing the latent cells, will be needed to achieve a cure.
http://news.unchealthcare.org/
The researchers plan to intensively study the immune responses generated by therapeutic vaccines, broadly neutralizing antibodies, and latency reversing agents in both acutely infected individuals and also in preclinical studies.
The «kick - and - kill» paradigm is aimed at combining latency reversing agents (LRA) with immune effectors, such as T - cells, to wake up the virus and kill the reactivated cells.
The team has made tremendous strides in learning about latency reversing agents or LRAs.
Not exact matches
The investigators have also studied cells from people living with HIV and found that serial dosing of LRAs is needed to reverse latency.
Olesen R, Vigano S, Rasmussen T, Søgaard OS, Ouyang Z, Buzon M, Bashirova A, Carrington M, Palmer S, Brinkmann CR, Yu XG, Østergaard L, Tolstrup M, Lichterfeld M. Innate immune activity correlates with CD4 T cell - associated HIV - 1 DNA decline during latency - reversing treatment with panobinostat.
Strategies to reverse HIV latency will likely require multiple rounds of treatment, and these new results suggest that noise - enhancing compounds may allow each round of treatment to be more effective at getting HIV to reveal itself.