Sentences with phrase «latent viruses»

«Stress can also slow wound healing, contribute to the reactivation of latent viruses and increase vulnerability to viral infections,» says Keri Tuit, clinical psychologist at Yale University.

Flu symptoms, very tired for days upon taking D. So, is the doctor correct that for some people, «D» reduces immune power and opens one up to latent viruses?

Dormant or latent viruses hide in cells, not in body fluids such as saliva or nasal secretions, Wylie explained.

Another problem is that all people normally carry latent viruses, which a healthy, functioning immune system usually keeps in check.

«We think this paper will stimulate others to carry out further investigations of the role of latent viruses in sepsis.»

A further direction for researchers is to determine whether PCR testing for a panel of latent viruses could be used as a readout of the state of a person's immunity.

«These results identify drug candidates that may prevent activation of latent viruses in astrocytes,» Schneider concluded.

And if this is the case, what does it mean in terms of the relationship between the latent viruses and longevity?

Other common latent viruses could be more uncomfortable if they reactivated on a trip to Mars — chicken pox, for example, which usually returns as shingles.

Latent viruses in the patient's body may reemerge during this time and when standard viral treatments fail, the infections can become life - threatening.

«Current treatments, which involve a complex cocktail of antiretroviral (ARV) medications, are fine - tuned to target and destroy active, replicating HIV — but they can't touch the latent virus,» explained Dr. Greene, director of virology and immunology research at Gladstone and professor of medicine at the University of California, San Francisco, with which Gladstone is affiliated.

This approach would activate the latent virus, and then bombard this newly active virus with ARVs.

Surprisingly, people who are infected with a latent virus, that is, an asymptomatic virus, have shorter telomeres.

Molecular, cellular and clinical changes that arise from an infection with a latent virus can result in a decrease in longevity.

Current HSV treatments, which target viral proteins, do not effectively control shedding or reactivation of latent virus.

The risk of reinfection is high, possibly due to auto - inoculation, spreading the infection by repeated contact between different sites on the body, or reactivation of a latent virus, or both.

Despite initial hopes that the drugs might eradicate the virus from the body, it soon became clear that no one was cured because of stubborn reservoirs of cells infected with latent virus.

These findings present a paradox, however, because latent virus can be of wild - type nucleotide sequence [33], and yet transcription is suppressed.

«You could start by shocking and killing the virus that's easy to target, then use silencing mechanisms to slow the resurfacing of latent virus.»

Researchers are exploring two main strategies to tackle this problem ---- reactivate and destroy the latent virus (called «shock and kill») or find a way to silence it for good.

But the latent virus can later become active, making the infection almost impossible to eradicate.

Latent virus in memory T cells is the reason current antiviral drugs can not cure HIV - infected patients.

Highly active antiretroviral therapy (HAART) has been highly successful in decreasing morbidity and mortality of HIV / AIDS, although other synergistic strategies are required to completely remove any cellular reservoirs of latent virus.

«Our findings provide the basis for a new model of HIV latency wherein SMYD2 contributes to durably repressing the latent virus,» said Ott.

The scientists will search for potent and nontoxic ways to wake up the latent virus, in order to precisely define the types of cells that comprise the reservoirs and allow for contraction of the reservoirs.

The scientists will start by searching for potent and nontoxic ways to wake up the latent virus, in order to precisely define the types of cells that comprise the reservoirs.

Potential new agents are also being investigated that it is hoped will overcome limitations of the current options, which include a narrow antiviral spectrum, ineffectiveness against latent virus infections, development of drug - resistance and toxic side effects.

Not exact matches

After the initial infection, the herpes simplex virus remains in nerve cells (ganglia) in an inactive or «latent» state.

A high percentage of the human population is infected with the herpes simplex virus and carries the virus in a latent state.

Even when latent, asymptomatic shedding of the virus continues its transmission.

That's the thinking behind some strategies to effectively eradicate latent reservoirs of HIV — thought to be the virus's last stand when under attack from increasingly effective drug cocktails.

Latent herpes virus infections may keep the immune system on alert, and thus better able to deal with other infectious agents.

Some virus experts had started to suspect that latent herpes viruses might use RNAi — a molecular trick that scientists first recognized a few years ago.

A permanent cure for HIV infection remains elusive due to the virus's ability to hide away in latent reservoirs.

«These animals carry latent HIV in the genomes of human T cells, where the virus can escape detection,» Dr. Hu explained.

However, no drug can cure infection so far, because various cell types continue to carry the virus in a latent, i.e. quiescent, state.

In the new study, expanding upon what scientists previously understood about intrinsic immunity, the researchers found that cells can subsequently respond to latent HCMV by employing other cellular proteins called lysine demethylases to reactivate the virus.

Once people are infected, they will have the virus their entire lives, due to its ability to cycle between latent and active states in the body.

Persistent, latent reservoirs of the virus make efforts to cure infection difficult.

«When you think about defending yourself against a virus, you usually think about turning it off, but this is what the virus wants to do when it goes latent,» Kalejta says.

This may have important implications for cure strategies aimed at eliminating the viral reservoir, as individuals infected with low replicative capacity viruses may have smaller latent viral pools that may be easier to eradicate.

«We were looking for viruses that people are commonly exposed to early in life and that persist in the body in a latent form that doesn't cause sickness,» said Storch, the Ruth L. Siteman Professor of Pediatrics.

Several previous studies have explored whether drugs can shock cells that are infected with latent HIV to make new viruses, setting them up for the kill by the natural immune response.

But those mice that were in latent stages of infection — carrying the virus but exhibiting no symptoms — survived the bacterial infections.

Further, those taking ARVs risk both a latent version of the virus, which can rebound if ARVs are discontinued, and the premature onset of diseases that normally occur in aging populations.

In addition, they could potentially make it possible to address a major obstacle to curing HIV: the virus's ability to establish a latent reservoir soon after infection, and so hide out in the body and evade treatment.

The HIV virus becomes latent or dormant — essentially hiding within the depths of that person's own organs and systems.

But most of those infected don't show symptoms like cold sores because the virus infection is «latent» or «silent» — sleeping — within the nervous system, where it remains for the entire life of its host.

Infection happens in peripheral tissues, then the virus particles enter axons and zoom into the distant cell nucleus, where the viral genetic information can become latent, sleeping for days or even years.

The combined use of therapeutic vaccination and specific drugs that can reactivate latent reservoir virus (Kick and kill strategies) hold the promise to achieve a functional cure for HIV infection.