An additional key insight gleaned from the structure, described in this week's Science, explains how the CCR5 receptor binding site on gp120 can have both the specificity required for tight binding and still be variable enough to allow the virus to switch to a different receptor
in later stages of infection.
This is compatible with a role for IL - 27 in dampening uncontrolled inflammation
at later stages of the infection, while initially allowing for a rapid immune defense.
In
the late stages of infection, the parasites not only disturb the sleep cycle but also cause paralysis, behavioral changes, and eventually death.
Most efforts to find safe, effective, low - cost drugs for malaria have focused on
the later stage of the infection when symptoms are the worst.
Now, researchers want to know what happens in
the later stages of infection and how to disable the pathogen.
The indirect immunofluorescent antibody assay (IFA) test is usually sent out to a diagnostic laboratory after a positive ELISA test to confirm FeLV infection and determine whether the cat has reached
the later stages of infection.
ELISA - type tests detect the presence of free FeLV particles that are commonly found in the bloodstream during both the early and
late stages of infection.