Not exact matches
The blood - brain barrier is a
layer of tightly packed
endothelial cells and connective
cells called astrocytes that strictly regulates the flow
of chemicals in and out
of the brain.
Epithelial
cells form tissue
layers that cover our skin and the inner surfaces
of most
of our internal organs, while
endothelial cells line the adjacent blood - transporting vessels and capillaries that support their functions.
Finally, the team added a
layer of the patient's own
endothelial cells, which promote smooth blood flow, on the inside
of the vessel.
Among other effects, immune
cells disrupt the function
of the
endothelial layer, the lining
of the blood vessels, counteracting «all the good things that the
endothelial cells produce,» says physiologist Brett Mitchell
of Texas A&M College
of Medicine in College Station.
To study this barrier and determine why a lack
of blood flow causes it to leak, the researchers built a blood - vessel - on - a-chip model consisting
of a channel lined with a
layer of human
endothelial cells surrounded by extracellular matrix within a microfluidic device, which allowed them to easily simulate and control the flow
of blood through a vessel and evaluate the
cells» responses.
Endothelial cells form the innermost
layer of the blood vessels - the endothelium - and have the function
of containing blood inside the vessels while allowing the passage
of nutrients to tissues.
Forty - eight hours after wounding, the
endothelial layer of cells (from the periphery all the way to the central area) showed considerable fluorescence due to BrdU incorporation.
These were mainly hemangiomas characterized by abundant capillaries lined by a single
layer of well - differentiated
endothelial cells.
The SPG
cell layer, which is adjacent to the neurons
of the brain, forms septate junctions, which function as a barrier to separate the humoral space and the brain, analogously to the mammalian tight junctions formed between
endothelial cells.
The iPS
cells are cultured on the opposite side
of the membrane in the other channel that represents the glomerulus» urinary compartment, where they are induced to form a
layer of mature podocytes that extend long cellular processes through the pores in the membrane and contact the underlying
endothelial cells.
Moreover, ES
cell differentiation in vitro recapitulates events that take place during early embryonic development including the formation
of the three germ
layers of ectoderm, mesoderm and endoderm, and the emergence
of endothelial, hematopoietic, cardiac, neuronal and hepatic or pancreatic
cells [8], [9].