Sentences with phrase «lead compounds»
Lead compounds refer to chemical substances that are used as starting points in drug discovery and development. They are typically tested for their biological activity against specific targets, such as disease-causing proteins or enzymes. These compounds serve as the foundation to create more effective and safer drugs through modification and optimization processes. Full definition
And they discovered that this invisible lead compound could be printed onto paper.
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«It's a profound idea,» says Mukund Chorghade, president of THINQ Pharma in Mumbai, India, who believes it would be a boon for drug discovery because it could provide untold numbers of lead compounds for developing new treatments.
MacCoss and Baillie (p. 1810) outline how the synthesis of more effective analogs of lead compounds now takes many cues from the more readily obtained data on bioavailability and toxicity.
Then, in groups of five, both RSC and GDCh students, we were given representations of real lead compounds from Pfizer?s history of research into drugs for combating such ailments as asthma and AIDS.
«Many of the compounds identified in this study promise to become lead compounds in near - future drug development efforts studies targeting this virus,» said Dr. García - Sastre, also the Fishberg Chair and Professor of Medicine (Infectious Diseases) within the School.
This is an actual resume example of a Pharmacy Technician Lead Compounding Technician who works in the Pharmacy Technicians Industry.
«Some racing fuels today still use lead compounds for boosting the octane rating of the fuel,» said Mathur.
Interested in Lead generation and Lead optimization and advancing lead compounds for Clinical trials based on potency, selectivity, optimized physicochemical properties (solubility), DMPK properties (P450 activity), and toxicity (in vivo acute...
Drug screening in a zebrafish model of SCN1A mutation has identified lead compounds for development of novel therapies.
Cosford had been investigating ULK1 using medicinal chemistry and chemical biology, and had identified some promising lead compounds using rational design.
We are pursuing both goals by studying the underlying biology, defining therapeutic targets, identifying active molecules by high - throughput screening and developing lead compounds.
Cosmetics were known thousands of years ago in ancient Egypt, where lead compounds were applied as foundation or eye makeup.
Robotics, genomics, high - throughput screening, combinatorial chemistry, and informatics tools have given companies far more lead compounds to sift through than they had in the past.
Taken together, the results show that AAPs are exceptionally promising new lead compounds for anti-TB drug development.
«It never ceases to amaze me how a simple molecule, such as saccharin — something many people put in their coffee everyday — may have untapped uses, including as a possible lead compound to target aggressive cancers,» says Robert McKenna, Ph.D., who is at the University of Florida.
Over the past few years, Carmot has built Chemotype Evolution into a robust technology that has yielded novel lead compounds targeting incretin receptors (GLP - 1R and GIPR) for treatment of Type 2 diabetes, obesity, and NASH and protein - protein interactions (NEMO / IKK) for treatment of cancer and inflammation.
Your job will be to advance lead compounds generated through Chemotype Evolution to clinical candidates.
Both of our RIPK2 small - molecule lead compounds inhibited c - ABL but with an IC50 of > 100 μM (Fig. 3A).
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«For drug discovery and development, you need to make variants of lead compounds.
We discovered our lead compounds, cabozantinib and cobimetinib, and advanced them into clinical development before entering into partnerships with leading biopharmaceutical companies in our efforts to bring these medicines to patients globally.
And in one of the feature's more exotic essays, we'll profile a Brazilian program that derives its lead compounds from tropical snake venom.
To the best of our knowledge, cordycepin has never been tested as a lead compound for osteoarthritis pain.»
Dr. Hadas Reuveni, the CEO of TyrNovo, a startup company formed for the clinical development of NT219, and Prof. Alexander Levitzki from the Department of Biological Chemistry at the Hebrew University, with their research teams, discovered a new set of compounds that inhibit the activity of the IGF1 signaling cascade in a unique and efficient mechanism, primarily for cancer treatment, and defined NT219 as the leading compound for further development.
«With adequate funding, we estimate that a lead compound could be tested in human patients within the next two to three years,» said Ray.
Trained as an enzymologist, Dr. Zhang has expertise in inhibition kinetics and mechanism of action studies for HTS hits and lead compounds.
The lead compound reported in the study, APS -2-79, was shown to modulate Ras signaling and increased the potency of several other cancer drugs within RAS - mutant cell lines.
The lead compound shows powerful antibacterial activity against clinical isolates of diverse pathogenic bacteria that are resistant to most antibiotics.
After a project lasting anywhere from 2 months to 2 years, the lead compounds he has made are passed on to the company's Optimisation Team, which works them up to the stage at which they can be developed into products.
Hermen Overkleeft, Professor of Bio-Organic Synthesis at Leiden University, added: «This work reveals the power of activity - based protein profiling: the probe described here at once enables screening for heparanase inhibitors from large compound collections and is a lead compound for drug development in its own right.
The high resolution structures are the starting point for the design of lead compounds that are endowed with high specificity, and can undergo further development for the design of highly specific, personalized drugs.
Among the top candidates, compound 213 (NSC56612) was selected as the lead compound by high - throughput screening.
In conclusion, using AMD070 as a lead compound, several series of heterocyclic related compounds were designed and synthesized.
In order to explore new pharmacophore moieties, FC131 was used as a lead compound for the development of novel CXCR4 antagonists.
From the test results of each chemical iteration of the lead compound, they were able to alter their chemical structures to make them much more potent.
Navire Pharma's lead compounds were discovered and developed by the IACS team led by Phil Jones, Ph.D., executive director and head of drug discovery at IACS, together with Benjamin G. Neel, M.D., Ph.D., director of the Laura and Isaac Perlmutter Cancer Center at New York University (NYU).
In drug discovery and screening pipelines, molecular biomarkers are used to assess the mechanism of action, efficacy, and toxicity of lead compounds.
We report here the design, synthesis, and pharmacological properties of a series of compounds related to tranylcypromine, which itself was discovered as a lead compound in a high - throughput screening campaign.
The trial uses FDG - PET imaging to examine the potential of its lead compound, LMTX ®, in delaying the progression of disease pathology in the brain.
The lead compounds have shown the ability to extend survival in a mouse model of SMA.
Reykjavik, ICELAND, May 10, 2005 — deCODE genetics (Nasdaq: DCGN) today announced the publication of a landmark article by a team of its scientists presenting the results of Phase II clinical studies of DG031, the company's lead compound being developed for the...
We explored if our lead compounds, RIPK2 inhibitors 1 and 2, can inhibit other targets at 100 nM in the 97 kinome panel (Supplemental Table 2A).
Through its SMA Project, a $ 32 million contract therapeutics development program that ran from 2003 until earlier this year, the agency identified a lead compound, dubbed ALB - 111, that induces the read - through of stop codons during protein production.
Utilizing mass spectrometry and 1H - NMR (Fig. 2; Supplemental Figs. 1 — 3A), we confirmed > 95 % purity of our two lead compounds and confirmed the structure of the identified RIPK2 inhibitors 1 and 2.
Selective 5 - hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: Identification of drugs in several animal models of CNS related disorders.