Sentences with phrase «lead compounds for»

Drug screening in a zebrafish model of SCN1A mutation has identified lead compounds for development of novel therapies.

Taken together, the results show that AAPs are exceptionally promising new lead compounds for anti-TB drug development.

«Some racing fuels today still use lead compounds for boosting the octane rating of the fuel,» said Mathur.

To the best of our knowledge, cordycepin has never been tested as a lead compound for osteoarthritis pain.»

Hermen Overkleeft, Professor of Bio-Organic Synthesis at Leiden University, added: «This work reveals the power of activity - based protein profiling: the probe described here at once enables screening for heparanase inhibitors from large compound collections and is a lead compound for drug development in its own right.

In order to explore new pharmacophore moieties, FC131 was used as a lead compound for the development of novel CXCR4 antagonists.

Not exact matches

The Washington Post reported that new, high - tech scanners search for organic compounds in explosives, which sometimes leads to false alarms when scanning food items.

«To his son, [Shelby] Davis passed along his infectious passion for owning shares in carefully chosen companies (he called them «compounding machines»), his conviction that owning the best compounding machines would lead to unimagined rewards, his distrust of unnecessary spending (why waste money they could be invested?)

Moreover, we are sometimes afflicted with a sense of impending crisis, lending force to Niebuhr's observation that «one of the most pathetic aspects of human history is that every civilization expresses itself most pretentiously, compounds its partial and universal values most convincingly, and claims immortality for its finite existence at the very moment when the decay which leads to death has already begun.»

Liverpool skipper Steven Gerrard's failure to qualify for the FA Cup final on his birthday could be further compounded by the painful reality that he could be leading his team in a guard of honour for champions - elect Chelsea at Stamford Bridge next month, the Daily Mail reports.

The strike merely added to an unsettled preseason for Nolan, who compounded his own problems when he traded Vic Washington, who scored eight touchdowns and led the team in rushing last season.

Last time out they drew 0 - 0 with rock - bottom Wigan − the second consecutive game (tenth overall) in which they had failed to find the back of the net, a dreadful result that was compounded by the news Darren Bent had picked up a serious injury that would sideline the club's leading scorer for the remainder of the term.

Bob Boutin, president of Skokie - based Knechtel Labs, a leading confectionary and food consultant, cautioned that brominated vegetable oil is an umbrella term that can be applied to different oils that may have been treated in a variety of ways, creating a wide variety of compounds used for different purposes.

In Northern Ireland, the election compounds the political turmoil, which followed the failure of the DUP - led power - sharing government, electoral losses for the DUP, and the subsequent inability of the unionist and nationalist parties to come to a new agreement.

«Sleep well Mr. Governor, with the knowledge that your action has compounded the loss of their loved ones and renewed the anguish and insufferable pain of the wanton murders of their family members by Judith Clark and her co-conspirators,» said James Stewart, the lead investigator for the Rockland County DA's office.

The discovery of another almost N15bn from the Osborne Ikoyi, Lagos luxury apartment appears to have put the Presidency on the spot; compounding what are turning out to be a burgeoning credibility and public relations burdens for the APC - led federal government.

In fact, the E.P.A. says the lake that Martens bobbed around in for about ten minutes while wearing a life jacket contains the following substances: «mercury, polychlorinated biphenyls (PCBs); pesticides; creosotes; heavy metals including lead, cobalt, and mercury; polycyclic aromatic hydrocarbons (PAHs); and volatile organic compounds (VOCs) such as chlorobenzene.»

«Simply put, the compound turns - off the sperm's ability to swim, significantly limiting fertilization capabilities,» said lead investigator Michael O'Rand, PhD, retired professor of cell biology and physiology in the University of North Carolina at Chapel Hill School of Medicine, and president / CEO of Eppin Pharma, Inc. «This makes EP055 an ideal candidate for non-hormonal male contraception.»

Now, testing of that compound is leading to a better prognosis for mice with the disease and the possibility of potential drugs that will improve outcomes for patients with SMA.

To try to develop a more sensitive probe for isolating individual peptides — short strands of amino acids — from a pool of similar molecules, a team led by chemist Clark Still of Columbia University 4 years ago synthesized small organic compounds that selectively fish out peptides dissolved in chloroform.

The drug - like compounds can be modified and developed into medicines that target a protein in the human body that is responsible for chemotherapy resistance in cancers, said biochemist Pia D. Vogel, lead author on the scientific paper reporting the discovery.

Garner has worked at AstraZeneca in Alderley Park, UK, for six years where he presently leads a team of eight people responsible for finding compounds that target cancer.

Chocolate, a food usually consumed for pleasure, in recent years has been reconsidered as a source of healthy compounds, noted lead researcher Joshua Lambert, associate professor of food science.

Lead, mercury, toluene, perchlorate, bisphenol A, flame retardants, perfluorinated compounds, organochlorine pesticides and phthalates are among the chemicals, according to the U.S. Centers for Disease Control and Prevention's nationwide testing program.

Scientists have finally isolated the compound responsible for this miracle of nature, which could aid the recovery of damaged lands and eventually lead to bigger farm yields.

Volcanic plumes were ideal crucibles for sparking stable nitrogen to form reactive compounds that led to the first organic molecules, chemists report in the 15 August Geophysical Research Letters.

Two years ago the pharmaceutical giant GlaxoSmithKline purchased Sirtris for $ 720 million, and by August of last year The New York Times was speculating that compounds capable of activating sirtuin genes were now the leading candidates for what the newspaper called «the ultimate free lunch... a drug that tricks the body into thinking it is on [a calorie - restricted] diet.»

Peter Gehring, a physicist for the National Institute of Standards and Technology (NIST), researches «smart» materials such as lead - oxide ferroelectric relaxors and highly magnetostrictive compounds.

The UCLA researchers, led by David Eisenberg, director of the UCLA - Department of Energy Institute of Genomics and Proteomics and a Howard Hughes Medical Institute investigator, report the first application of this technique in the search for molecular compounds that bind to and inhibit the activity of the amyloid - beta protein responsible for forming dangerous plaques in the brain of patients with Alzheimer's and other degenerative diseases.

«For drug discovery and development, you need to make variants of lead compounds.

The researchers, led by Sara Jaeger, Jeremy McRae, and Richard Newcomb of Plant and Food Research in New Zealand, found that for four of the ten odors tested, there was indeed a genetic association, suggesting that differences in the genetic make - up determine whether a person can or can not smell these compounds.

Measuring and understanding these compounds present in museums and libraries could aid in preservation of their collections, and might even lead to recreation of historic smells for bookworms everywhere to enjoy.

A team led by Professor Oganov developed the world's most universal and powerful algorithm for crystal structure and compound prediction — USPEX (Universal Structure Predictor: Evolutionary Xtallography).

CREATIVE CHEMISTRY Sarah Reisman spends her days thinking about innovative ways to build complicated chemical compounds that could lead to new drugs for numerous ills.

«Recently, the attention of scientists has been attracted to endocrine - disrupting chemicals (EDCs), compounds that are suspected of promoting the development of various metabolic disorders via their capacity to impact hormonal and metabolic signaling pathways,» said lead author Shane Regnier, a doctoral candidate at the University of Chicago's Committee for Molecular Metabolism & Nutrition.

«New compound for slowing aging process can lead to treatments for brain diseases.»

Trained as an enzymologist, Dr. Zhang has expertise in inhibition kinetics and mechanism of action studies for HTS hits and lead compounds.

«The evidence from observation indicates that complex organic chemistry is much more universal than previously thought,» says Fred Goesmann from the Max Planck Institute for Solar System Research, who led the analysis of organic compounds on the Rosetta mission.

Dr. Walter Voit led the team that created «Polycraft World,» an adaptation or «mod» for «Minecraft» that allows players to incorporate the properties of chemical elements and compounds into game activities.

For example, creative problem - solving AI could someday make snap decisions that save the lives of the passengers in a self - driving car if its sensors fail, or propose unconventional combinations of chemical compounds that lead to new drugs for previously untreatable diseasFor example, creative problem - solving AI could someday make snap decisions that save the lives of the passengers in a self - driving car if its sensors fail, or propose unconventional combinations of chemical compounds that lead to new drugs for previously untreatable diseasfor previously untreatable diseases.

Lead author Nigel D'Souza, then a postdoctoral researcher at Lamont, discovered the phytoplankton response to oil seeps while on a ship in the Gulf of Mexico monitoring chlorophyll fluorescence — energy that is emitted as light by compounds inside phytoplankton cells used for photosynthesis.

The institute's international reputation in natural compound research and the institute's collaborations with leading pharma firms are surely also important parts for the successful start of ActinoDrug.

Michael Blaut, a microbiologist at the German Institute of Human Nutrition in Potsdam, Germany, says the mouse data are «believable and remarkable,» but says he has a hard time imagining a mechanism that would account for three compounds as chemically different as aspartame, saccharin, and sucralose leading to the same changes in the gut microbiome.

«Despite the increased quality risks and the lack of safety and efficacy data for non-FDA regulated custom - compounded bioidentical hormones, their use by menopausal women is higher than expected and appears to be continuing to grow,» said lead researcher JoAnn Pinkerton, MD, a professor of obstetrics and gynecology at the University of Virginia Health System, Charlottesville.

As part of the long effort to improve treatment of tuberculosis (TB), microbiologists led by Yasu Morita at the University of Massachusetts Amherst report that they have for the first time characterized a protein involved in making a glycolipid compound found in the TB cell wall, which is critical for the disease - causing Mycobacterium to become infectious.

In the new study, led by Purdue biochemist Natalia Dudareva, the team looked for genetic changes as the plant developed from its budding stage, which had the lowest levels of volatile organic compounds, to its flower - opening stage, with the highest levels.

Best of all, the derivatives were even more effective than the original compound, without leading to that worrisome estrogenic metabolite or showing much affinity themselves for estrogen receptors.

If the compound identified in this study successfully reduces tissue death and improves recovery in further experiments, it could lead to new approaches for preserving brain cells after an ischemic stroke,» said Francesca Bosetti, Ph.D., Pharm.D., program director at the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

Researchers have used the compound to create a high - performance «flow» battery, a leading contender for storing renewable power in the electric utility grid.

«The dBET1 and the dFKBP12 compounds are presently in a late stage of lead optimization for therapeutic development in both cancer and non-malignant diseases,» says Prem Das, PhD, chief research business development officer at Dana - Farber.