Sentences with phrase «lead compounds in»

We report here the design, synthesis, and pharmacological properties of a series of compounds related to tranylcypromine, which itself was discovered as a lead compound in a high - throughput screening campaign.

Not exact matches

The Washington Post reported that new, high - tech scanners search for organic compounds in explosives, which sometimes leads to false alarms when scanning food items.

The Economist extrapolates that even a 2 percent bump on a $ 45,000 a year salary can lead to as much as an extra $ 67,000 over the course of a 40 - year working career, if you were to set aside your language bump in savings and figure in compound interest.

We discovered our lead compounds, cabozantinib and cobimetinib, and advanced them into clinical development before entering into partnerships with leading biopharmaceutical companies in our efforts to bring these medicines to patients globally.

«This question is significantly compounded by the complete lack of any documentation about the process leading up to the termination,» Cook wrote in his ruling, released August 22.

«To his son, [Shelby] Davis passed along his infectious passion for owning shares in carefully chosen companies (he called them «compounding machines»), his conviction that owning the best compounding machines would lead to unimagined rewards, his distrust of unnecessary spending (why waste money they could be invested?)

This led to the formation of «mission compounds» and social ghettos where Christians could take their place as one more subcaste or subsect among the thousands of such subcastes and subsects in India.»

When sulfur dioxide gets into the atmosphere and meets nitrogen oxides, compounds are formed that lead to acid in the rain.

About Barry Callebaut Group (www.barry-callebaut.com): With annual sales of about CHF 6.2 billion (EUR 5.6 billion / USD 6.6 billion) in fiscal year 2014/15, the Zurich - based Barry Callebaut Group is the world's leading manufacturer of high - quality chocolate and cocoa products — from sourcing and processing cocoa beans to producing the finest chocolates, including chocolate fillings, decorations and compounds.

The purple range, which comes just one week after leading cocoa processor Barry Callebaut announced it has developed pink chocolate, derived naturally by isolating specific compounds in cocoa beans.

As the world's leading cork producer, Amorim has stood at the forefront of the fight against TCA — a naturally forming chemical compound that is a problem in the packaged food and beverage industries — through the application of rigorous production standards and certified quality control methods.

Tara Jensen hosts a monthly pizza night, and every time she's sure that no one will come, and every time, nearly 100 people show up, finding their way to the town of Marshall, North Carolina, then heading six miles northwest on Route 70 along the French Broad River, winding around the knoll called Walnut, and stopping at the dirt driveway leading to her compound, which consists of an algae - covered pond, a shack in the woods, a brick oven, and two pitched - roof houses, one of which is a bakery that goes by the name of Smoke Signals.

Barry Callebaut: With annual sales of about CHF 4.9 billion (EUR 4.0 billion / USD 5.2 billion) in fiscal year 2012/13, Zurich - based Barry Callebaut is the world's leading manufacturer of high - quality chocolate and cocoa products — from sourcing and processing cocoa beans to producing the finest chocolates, including chocolate fillings, decorations and compounds.

Barry Callebaut: With annual sales of about CHF 5.9 billion (EUR 4.8 billion / USD 6.5 billion) in fiscal year 2013/14, the Zurich - based Barry Callebaut Group is the world's leading manufacturer of high - quality chocolate and cocoa products — from the origination and processing cocoa beans to producing the finest chocolates, including chocolate fillings, decorations and compounds.

There is racial inequity: less of the overall resources are ending up in predominantly black neighborhoods, which leads to compounding issues in many areas, be it health, law, education... you get the idea.

Liverpool skipper Steven Gerrard's failure to qualify for the FA Cup final on his birthday could be further compounded by the painful reality that he could be leading his team in a guard of honour for champions - elect Chelsea at Stamford Bridge next month, the Daily Mail reports.

The strike merely added to an unsettled preseason for Nolan, who compounded his own problems when he traded Vic Washington, who scored eight touchdowns and led the team in rushing last season.

Compounding his effect in the engine room is the fact that after scoring yet another fabulous goal at the Liberty Stadium, Ramsey is now sharing the league lead with four goals to go with four more he's added in the Champions League.

Last time out they drew 0 - 0 with rock - bottom Wigan − the second consecutive game (tenth overall) in which they had failed to find the back of the net, a dreadful result that was compounded by the news Darren Bent had picked up a serious injury that would sideline the club's leading scorer for the remainder of the term.

Granting this wide - ranging request would further compound confusion in the marketplace and lead to more misleadingly labeled dairy products.

Bob Boutin, president of Skokie - based Knechtel Labs, a leading confectionary and food consultant, cautioned that brominated vegetable oil is an umbrella term that can be applied to different oils that may have been treated in a variety of ways, creating a wide variety of compounds used for different purposes.

Some online forums and websites have posted misleading or inaccurate information about the ingredients in vaccines, leading some moms to worry about their safety — specifically, singling out thimerosal, which is an ethylmercury - containing compound sometimes used to keep vaccines safe from contamination.

Too much salt can tax kidneys, and potentially compound in baby's system and lead to renal failure.

In Northern Ireland, the election compounds the political turmoil, which followed the failure of the DUP - led power - sharing government, electoral losses for the DUP, and the subsequent inability of the unionist and nationalist parties to come to a new agreement.

We advised that the Buhari led government should ensure an improvement in electricity supply first as increase in tariff, establishment of various taxes without justification among others will only compound the sufferings of Nigerians.

During cooking, a lot of interesting chemical reactions occur which lead to the formation of some other chemical compounds which were neither components of the raw food material nor nutrients in themselves.

In fact, the E.P.A. says the lake that Martens bobbed around in for about ten minutes while wearing a life jacket contains the following substances: «mercury, polychlorinated biphenyls (PCBs); pesticides; creosotes; heavy metals including lead, cobalt, and mercury; polycyclic aromatic hydrocarbons (PAHs); and volatile organic compounds (VOCs) such as chlorobenzene.&raquIn fact, the E.P.A. says the lake that Martens bobbed around in for about ten minutes while wearing a life jacket contains the following substances: «mercury, polychlorinated biphenyls (PCBs); pesticides; creosotes; heavy metals including lead, cobalt, and mercury; polycyclic aromatic hydrocarbons (PAHs); and volatile organic compounds (VOCs) such as chlorobenzene.&raquin for about ten minutes while wearing a life jacket contains the following substances: «mercury, polychlorinated biphenyls (PCBs); pesticides; creosotes; heavy metals including lead, cobalt, and mercury; polycyclic aromatic hydrocarbons (PAHs); and volatile organic compounds (VOCs) such as chlorobenzene.»

The President said that besides the menace of Boko Haram, the concept of host and settler communities had compounded the migration problem in the country, leading to clashes.

His defeat in compounded Labour's woes in a dismal night, which saw the party lose all but one of its Scottish MPs and will undoubtedly lead to Ed Miliband standing down.

(CNN)- Rep. Michael Grimm on Monday likened the recent bombings in southern Russia to the security threats leading up to the deadly 2012 attack on a U.S. compound in Benghazi, Libya, as well as red flags ahead of the Boston Marathon bombings.

«Simply put, the compound turns - off the sperm's ability to swim, significantly limiting fertilization capabilities,» said lead investigator Michael O'Rand, PhD, retired professor of cell biology and physiology in the University of North Carolina at Chapel Hill School of Medicine, and president / CEO of Eppin Pharma, Inc. «This makes EP055 an ideal candidate for non-hormonal male contraception.»

To get around that problem, a group at the Department of Energy's Ames Laboratory in Iowa, led by Vitalij Pecharsky — a materials scientist with a joint appointment at Iowa State University, Ames — started with powdery organic compounds, such as phosphonium salts, solid aldehydes or ketones, and anhydrous potassium carbonate.

To try to develop a more sensitive probe for isolating individual peptides — short strands of amino acids — from a pool of similar molecules, a team led by chemist Clark Still of Columbia University 4 years ago synthesized small organic compounds that selectively fish out peptides dissolved in chloroform.

A team led by Stuart Licht at the Technion - Israel Institute of Technology in Haifa has come up with a new cathode made from unusual iron - based molecules — iron (VI), or «super-iron,» compounds — that absorb more electrons than manganese dioxide.

Mercury, lead, chromium and other toxic compounds, used in many industrial processes, rob years of healthy life from millions each year.

And in one of the feature's more exotic essays, we'll profile a Brazilian program that derives its lead compounds from tropical snake venom.

The drug - like compounds can be modified and developed into medicines that target a protein in the human body that is responsible for chemotherapy resistance in cancers, said biochemist Pia D. Vogel, lead author on the scientific paper reporting the discovery.

In 1987, an international agreement known as the Montreal Protocol led to a ban on the production and use of CFCs and many related compounds in industrial nations, but it ignored CH2Cl2 because researchers thought it didn't stay intact in the atmosphere long enough to rise into the stratospherIn 1987, an international agreement known as the Montreal Protocol led to a ban on the production and use of CFCs and many related compounds in industrial nations, but it ignored CH2Cl2 because researchers thought it didn't stay intact in the atmosphere long enough to rise into the stratospherin industrial nations, but it ignored CH2Cl2 because researchers thought it didn't stay intact in the atmosphere long enough to rise into the stratospherin the atmosphere long enough to rise into the stratosphere.

The objective of the research project led by Marko Kallio, Principal Scientist at VTT, was to accelerate the drug development process by identifying new compounds that would possess similar binding properties and cellular phenotype, but a different chemical structure, as the selected drugs in clinical use or investigational compounds in development.

Cosmetics were known thousands of years ago in ancient Egypt, where lead compounds were applied as foundation or eye makeup.

Thermolysis of the applied tosyl hydrazones (easily prepared by condensation of the corresponding aldehydes with tosyl hydrazine) leads to in situ formation of the corresponding diazo compounds.

Garner has worked at AstraZeneca in Alderley Park, UK, for six years where he presently leads a team of eight people responsible for finding compounds that target cancer.

In a paper published January 2, 2018, in Nature Communications, Berkeley Lab researchers led by the Northen lab report that specific compounds are transformed by and strongly associated with specific bacteria in native biological soil crust (biocrust) using a suite of tools Northen calls «exometabolomics.&raquIn a paper published January 2, 2018, in Nature Communications, Berkeley Lab researchers led by the Northen lab report that specific compounds are transformed by and strongly associated with specific bacteria in native biological soil crust (biocrust) using a suite of tools Northen calls «exometabolomics.&raquin Nature Communications, Berkeley Lab researchers led by the Northen lab report that specific compounds are transformed by and strongly associated with specific bacteria in native biological soil crust (biocrust) using a suite of tools Northen calls «exometabolomics.&raquin native biological soil crust (biocrust) using a suite of tools Northen calls «exometabolomics.»

A global team led by University of Edinburgh chemists made a series of metallo - carbon neptunium compounds and carried out in - depth analyses to determine their molecular and electronic structures.

Chocolate, a food usually consumed for pleasure, in recent years has been reconsidered as a source of healthy compounds, noted lead researcher Joshua Lambert, associate professor of food science.

«This may be an adaptation in order to avoid intake of bitter - tasting, toxic compounds,» says Marijke Faas of the University Medical Centre in Groningen, the Netherlands, and lead author of the Chemosensory Perception paper.

«The compounds identified in this study, when administered orally, both reduced the inflammation that is a hallmark of multiple sclerosis and protected against the nerve cell damage seen in mouse models of the disease,» said Jeffery Haines, PhD, a post-doctoral fellow at Mount Sinai and the study's lead author.

The PAM used in the IU - led study worked by amplifying two brain compounds — anandamide and 2 - arachidonoylglycerol — commonly called «endocannabinoids» because they act upon the CB1 receptor in the brain that responds to THC, the major psychoactive ingredient in cannabis.

«The deposition of compounds such as sugars and organic acids from living roots can increase the activity of bacteria and fungi, and it's this increase in activity that accelerates the decomposition of carbon in the soil, leading to higher CO2 emissions,» Sulman said.

A COMPOUND that slows the proliferation of triple - negative breast cancer cells in lab tests could lead to the first drugs to target this aggressive type of tumour.