Sentences with phrase «lead risk reduction»

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

That delay translated to a 30 % relative reduction of risk that the disease would progress or lead to death, according to the study, which was published in August in the New England Journal of Medicine.

There are smaller studies that suggest drinking coffee can lead to even bigger risk reductions for Alzheimer's.

Leading clinical investigations seeking to address cardiovascular risk reduction beyond lowering LDL - C focus on interrupting the atherosclerotic process (e.g., plaque formation and instability) by beneficially affecting other lipid, lipoprotein and inflammation biomarkers and cellular functions thought to be related to atherosclerosis and cardiovascular events.

This sort of loosening, combined with the reduction in risk resulting from a better safety net and basic income, plus the possibility of building working capital through gigs, could lead to an explosion in creativity and entrepreneurial activity

Don't go barking up the wrong tree in the Year of the Dog A predictable wave of profit taking and risk reduction, as is standard form ahead of US long weekends, dominated Friday session leading to USD gains as US yields pulled back.

Secondly, the value of fixed income instruments will become impaired (perhaps significantly given that mortgages have considerable duration / extension risk) as rates rise; such impairments will hit bank equity, and could lead to risk reduction maneuvers.

LENDonate also assesses nonprofit borrowers for credit enhancement opportunities that lead to reduction of credit risk and borrowing rates.

Apart from reducing the risk of product recalls, CCI testing also proves to be less time - consuming than most sterility test methods, and can also lead to significant cost reductions.2

He established and leads the innovative China Salt Substitute and Stroke Study (SSaSS), a 21,000 - person cluster randomised trial in rural China investigating whether salt reduction reduces the risk of stroke.

As a result, you'll see improvements in risk assessment, a reduced burden on mothers, reduced risk of domestic violence, enhanced resources for the care of children and better risk management — leading ultimately to the reduction of harm.

The data «could indicate that the potential window of opportunity for optimized ACL injury risk reduction may be before the onset of neuromuscular deficits and peak knee injury incidence that occurs after the onset of maturation in female athletes and / or during the mid-teen years,» said lead author, Gregory D. Myer, PhD, FACSM, CSCS, of the Division of Sports Medicine at Cincinnati Children's Hospital, and the Departments of Pediatrics and Orthopaedic Surgery, at the College of Medicine at the University of Cincinnati, and the Athletic Training Division, School of Allied Medical Professions at The Ohio State University in Columbus.

• Better engagement with fathers and father - figures in families where children are at risk is likely to result in better risk assessment, reduced burden on mothers, enhanced resources for the care of children and better risk management, leading to reduction of harm (Zanoni et al, 2013).

«Making cycle helmets compulsory would be likely to have an overall damaging effect on public health, since the health benefits of cycling massively outweigh the risks and we know that where enforced, helmet laws tend to lead to an immediate reduction in cycling,» policy coordinator Chris Peck said.

Treatment with the diabetes drug liraglutide, in combination with diet and exercise, led to a significant reduction in weight and improved a number of cardiovascular risk factors, including high blood pressure and high cholesterol, according to a multicenter study.

He said that would translate into a five to six per cent reduction in the risk of cardiovascular disease, the leading cause of death in the United States.

This shows that an exchange of few commercially available food items was easy and manageable and leads to clinically relevant cholesterol reduction potentially affecting future CVD risk.

«We found that in tsunami - prone areas, people who have participated in community activities are more likely to undertake disaster risk reduction actions,» says IIASA researcher Raya Muttarak, who led the study.

Ablation also led to an 11 percent reduction in risk for health care for AF but only a negligible drop in risk for acute stroke.

For instance they contain many antioxidants, which may reduce DNA damage, and lead to a reduction in cancer risk.»

Dr Kristensen said: «It will be interesting to see if these medications, which are increasingly used in IBD, lead to a reduction in the risk of heart failure and other cardiovascular diseases.

«Our study demonstrates that in patients with mild - moderate obesity and type 2 diabetes, gastric bypass surgery leads to a sustained reduction in weight, improvement in glycemic control, and decrease in cardiovascular risk compared to a medical diabetes and weight management program,» said lead author Donald C. Simonson, M.D., M.P.H., Sc.D., of the BWH Division of Endocrinology, Diabetes and Hypertension.

The current study, and studies like it that use animal models, could contribute to determining human health risks and developing policies leading to a reduction in both exposure to THS and disease.

«The primary goal of GEP testing is to identify patients at high recurrence risk who will benefit from chemotherapy, while allowing patients with a low recurrence risk to forego chemotherapy, potentially offsetting the test costs with savings from reductions in chemotherapy use,» wrote authors led by Young Chandler, PhD, of the Georgetown Lombardi Comprehensive Cancer Center in Washington, DC.

And the greater work of catalyzing the transition of biomedical research generally from targeting metabolic pathways for «risk factor» reduction in favor of repair of the lesions that accumulate in a tissues, impair their function, and lead to morbidity and mortality must be realized.

«Increasing calcium intake from dietary sources or by taking calcium supplements produces small non-progressive increases in BMD, which are unlikely to lead to a clinically significant reduction in risk of fracture,» the study authors conclude.

Higher intake does not lead to a further reduction in mortality risk.

«Improvements in both may lead to the largest reductions in the risk of premature death.»

Not only was regular bean consumption as effective as portion control in reducing prediabetes risk factors like slimming waistlines and better blood sugar control, but the bean diet led to additional benefits beyond just calorie reduction, presumably due to some functional properties of the beans and peas.

Reducing this seems to lead to improved mood and cognition, as well as a reduction in birthing problems, chronic fatigue, and cancer risk.

Tomatoes include several nutrients associated with beneficial cardioprotective effects, including the reduction of cholesterol levels and blood pressure, which in turn lead to a decreased risk of stroke.

By the end of the study, the flaxseed group had significant improvements in all lipid levels and blood pressure values compared to the placebo group, leading to a substantial reduction in cardiovascular risk.

One study showed that 6 months of soy protein consumption led to a reduction in prostate cancer, the results of a meta - analysis also concluded than consumption of soy protein is directly associated with a reduction in the risk of prostate cancer among men.

This superior ability to absorb energy is probably why eccentric training then leads to a reduction in the risk of getting a muscle strain injury.

This leads to a reduction in breast cancer incidence, as tamoxifen can lower the risk of the disease by 30 to 50 percent in high - risk women, she adds.

This then leads to the reduction of the risk of getting chronic diseases.

Long - term use of the pill was linked to reductions in risk for both cancers, and this was «generally consistent across health behaviors,» according to a team led by Kara Michels, a cancer institute epidemiologist.

In its thirty year history, CISAS has been a regional training center for Child - to - Child and has developed child - led programs addressing health promotion, ecology awareness, child rights, disaster risk reduction, and other issues.

Reducing risk With no reference to the effect of risk reduction measures upon the benefits, say, of leading a school outing, or conducting an experiment in class, risk reduction becomes an insatiable and boundless task which could eliminate much that is otherwise valued.

Together these deliver good diversification, which leads to risk reduction and return stability.

Hindsight bias sufferers underestimate volatility, which leads to ineffective use of risk - reduction strategies.

The positive emotions gained from simply stroking a pet can lead to dramatic reduction of major cardiac risk factors and calm both body and mind.

Spaying before age 2 years leads to an 11 % reduction in risk.

She developed programs and partnerships that transferred cats and kittens at high risk for euthanasia resulting in a 79 % reduction and implemented targeted, aggressive TNR programs which lead to in a 45 % drop in cat intake at Manatee County Animal Services over five years.

It also leads to a drastic reduction in indoor and ambient air pollution, better visibility and reduced health risk.

In weather systems, convergence of increased water vapor leads to more intense precipitation and the risk of heavy rain and snow events, but may also lead to reductions in duration and / or frequency of rain events, given that total amounts do not change much.

This activity report showcases how WFP implements concrete disaster risk reduction activities, as natural disasters are a leading cause of hunger.

While Bangladesh is well - known for the natural calamities that regularly leave millions of people homeless and displaced, far fewer know that it is also one of the most proactive countries in the fields of disaster risk reduction (DRR) and climate adaptation, as well as a leading voice among the poorest countries in climate negotiations.

The latter point is supported by the results in Fig. 5 showing how, for fixed risk reduction values, rising flood protections lead to larger socio - economic impacts than in the case of relocation and vulnerability reduction.

On the other hand, structural measures for vulnerability reduction lead to higher risk reduction rates, at the expense of more considerable investments.