Sentences with phrase «lead the cell line»

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Not exact matches

... In lung cancer cell lines, CBD upregulated ICAM - 1, leading to...

DNA from the cell nucleus, which includes both maternal and paternal lines, tells a different story: The two types of elephants are in fact separate species, leading recently to a proposed relisting of the forest elephant as Loxodonta cyclotis.

Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environment.

In 2012, Korch was the lead author on a paper exposing 19 false endometrial and ovarian cell lines.

An enduring mystery of atherosclerosis — the blockage of arteries that can lead to heart attack and stroke — is why T cells flock to atherosclerotic lesions, sites of inflammation lining blood vessels.

The new research shows that when the atheronals interact with various blood cells, they produce some of the effects known to lead to heart disease, such as causing a malfunction in the cells that line arterial walls.

Top series: Images show the elongated shape of cells transforming into a ball shape before they shed from the lining of the airway to cause obstruction, a key reason why RSV leads to bronchiolitis.

The prolonged presence of asbestos fibers lodged in the organ lining initiates a vicious cycle of chronic cell death and chronic inflammation that, over a period of many years, can lead to mesothelioma.

Breast cancer researchers have mapped early genetic alterations in normal - looking cells at various distances from primary tumours to show how changes along the lining of mammary ducts can lead to disease.

In 2008 a group of medical researchers led by Robert Lanza at Advanced Cell Technology in Worcester, Massachusetts, reported another leap: They discovered a way to avoid destroying the embryo by deriving an entire stem cell line from a single embryonic cCell Technology in Worcester, Massachusetts, reported another leap: They discovered a way to avoid destroying the embryo by deriving an entire stem cell line from a single embryonic ccell line from a single embryonic cellcell.

British newspapers reported this weekend that Ian Wilmut, the University of Edinburgh biologist who led the team that in 1997 cloned Dolly the sheep, is getting out of the cloning business in light of the new findings, which seem to offer researchers a likely new source of stem cell lines for basic research that could one day lead to new treatments and perhaps cures for spinal injuries, diabetes and debilitating disorders such as multiple sclerosis and Parkinson's disease.

In a new study published in Scientific Reports, Tokyo Medical and Dental University (TMDU)- led researchers investigated photodynamic detection of cancer stem cells in a glioma cell line, a model of a highly aggressive type of brain cancer.

A team of researchers in Germany and Denmark led by Steven Johnsen, Professor at the University Medical Center Göttingen, Germany, used human prostate cancer cell lines and depleted them of the DNA - binding protein CHD1.

«Patients with non-small cell lung cancer (NSCLC) should receive front line therapy with the anaplastic lymphoma kinase (ALK) inhibitor crizotinib,» said lead author Professor Giorgio Scagliotti, head of the Department of Oncology, University of Turin, Italy.

The causes of such unpredictable results, Harris said, can include bad ingredients in the lab, including contaminated and misidentified cell lines; poor research design, including insufficient numbers of mice in animal studies; statistical error and overreach, including «HARKing» (hypothesizing after the results are known), a push beyond the limits of the data; and funding pressures, which can lead scientists to hype or exaggerate their results to remain competitive for additional grant money.

«Endothelial cells make up the inner lining of blood vessels,» said William Durante, Ph.D., professor of medical pharmacology and physiology at the MU School of Medicine and lead author of the study.

Knowing more about the activation process has led researchers to be able to induce greater vulnerability by cancer cells to an existing first - line treatment for cancers (mainly lung) driven by a receptor called EGFR.

Aging in intestinal stem cells leads to changes in villi, the finger - shaped protuberances that line the small intestine and absorb nutrients, and crypts, the valleys between villi where the intestinal stem cells live.

The five - year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cells.

Yet, «these studies using HeLa cells had to rely on information from the «reference» sequence produced by the Human Genome Project, even though there was evidence that the genomes of HeLa cell lines were probably quite different,» said Lars Steinmetz, Ph.D., who led the G3 study.

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channel.

These lines are available for researchers funded by the US National Institutes of Health (NIH) and the California Institute for Regenerative Medicine (CIRM) in San Francisco, says Jeremy Crook, a stem cell biologist at the University of Melbourne, Australia, who led the team that made the lines.

This work, led by Dr Patrick Varga - Weisz shows how chemicals produced by bacteria in the gut from the digestion of fruit and vegetables can affect genes in the cells of the gut lining.

The four Finn Dorsets were derived from the mammary gland cell line that led to the birth of Dolly.

The destruction of cells lining the gut leads to abdominal cramping, watery diarrhea, and eventually bloody diarrhea.

«We set out to test this in cell lines derived from mice and humans, and came up with a result we definitely did not expect — which then led us to dig deeper for answers.»

The force of that blood flow helps keep the cells that line the blood vessels, called endothelial cells, healthy; when blood flow is disrupted, such as during surgical procedures or a stroke, the vessels start to leak, which can cause a host of inflammatory responses that lead to cell damage and disease.

Using cutting edge «disease in a dish» technologies, the researchers are now following up the leads discovered in blood cell lines in neurons induced from stem cells derived from the blood of PMDD patients — in hopes of gaining a more direct window into the ESC / E (Z) complex's role in the brain.

Researchers from the University of Cambridge studied a variety of cell lines, including human neural stem cells, to investigate how Zika virus infection can lead to microcephaly.

An international team led by researchers at Johns Hopkins University in Baltimore, Maryland, compared early - passage and late - passage versions of nine human ES cells lines obtained from labs around the world.

«We wanted to see whether very - large - scale screening across a diverse collection of cancer cell lines and a large number of drugs could yield new combinations for patients with cancer,» says Adam Friedman, MD, PhD, of the CBRC and the MGH Cancer Center, who led the study.

Because type III cells appear to integrate information from other receptor cells (Tomchik et al., 2007) and use the 5 - HT3 system to transmit information, these previous nerve recording studies may have inhibited transmission of integrated cross-modal information from type III cells, leading to the appearance of strict labeled - line, modality - specific transmission of information.

The discovery of NGF has also promoted an intensive search for other specific growth factors, leading to the isolation and characterization of a number of proteins with the ability to enhance the growth of different cell lines.

Now, however, a team of researchers led by Yu - Hua Tseng, Ph.D., Investigator in the Section on Integrative Physiology and Metabolism at Joslin Diabetes Center and an Associate Professor of Medicine at Harvard Medical School, has created cell lines of human brown and white fat precursor cells that will help investigators to pick apart the factors that drive the development and activity of each type of cell.

The authors were led into the realm of muscle and sex when they realized that they were relying heavily on cell lines derived from female mice to study muscle regeneration.

These factors, together with damage to the lining of the blood vessels, can lead to permanent changes in the immune cells.

In the present work, our observations led us to conclude that inhibition of TRF2 abrogates the formation and maintenance of the spheroidal phenotype and loss of TRF2 results in down regulation of CSC characteristics when exposed to DNA damaging environment in HCT116 colon cancer cell line.

My post-doctoral work on the identification of genes required for normal germ line development and fertility led to the discovery that the germ line is exquisitely sensitive to mutations in components of the mitotic spindle that have the potential to lead to aneuploidy — this sensitivity may also extend to embryonic and adult stem cells.

take a lead in developing the next generation of cancer cell lines and use cell lines to systematically explore in vitro sensitivity to large numbers of anticancer drugs and drug combinations in order to inform choice of cancer types for early drug trials.

Leading US research institutions may stop studying several federally - fundable linkurl: embryonic stem cell; https://www.the-scientist.com/blog/display/54749/ lines due to potential ethical problems surrounding the creation of the lines.

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

Diverse signaling pathways through the SDF - 1 / CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis.

We are the home of the UK Stem Cell Bank which provides a world - leading resource of ethically - sourced, quality - controlled human embryonic and other stem cell lines for research applicatiCell Bank which provides a world - leading resource of ethically - sourced, quality - controlled human embryonic and other stem cell lines for research applicaticell lines for research applications.

These abnormal cells — in the case of pulmonary hypertension, those that line the blood vessels leading to the lungs — release signals that stimulate the growth of small new blood vessels to feed the renegade cells, allowing further proliferation, and thickening of the vessel walls.

As shown in Fig. 2A, exogenous expression of DDX3 in various cell lines led to a 2 - to 4-fold up - regulation of p21waf1 / cip1 promoter — driven luciferase activity.

Our combined in vitro and in vivo expertise shapes a broad portfolio of design (ES cell, CRISPR / Cas9, random DNA insertion), breeding and associated services to create and maintain the most relevant models for your studies.Rely our industry - leading germ line transmission, strict quality controls, fast turnaround and dedicated project managers to help you successfully reach your goals.

The ALD stem cell line wouldn't have happened without one other key player: the ALD Foundation, an awareness, support and fundraising organization led by a man who recently lost his stepson to the disease.

To evaluate whether ABL kinases might regulate the secretion of osteoblast - derived RANKL or OPG leading to osteoclast differentiation, we analyzed RANKL and OPG mRNA abundance in the murine osteoblast cell line 7F2 in response to conditioned medium from control and ABL1 / ABL2 knockdown breast cancer cells.

He could have left the funding of research involving cell lines created by the destruction of human embryos in place, and led the charge to promote ethically unproblematic non-embryo-destructive forms of stem cell science.