Sentences with phrase «lead to cancer cell»

The same study also suggests that the nutrient could lead to cancer cell death, also called apoptosis.

While estrogen is essential for healthy cell growth, high lifelong exposure can cause rapid cell division that may lead to cancer cell mutation.

Either drink delivers a sugar shot that increases insulin and insulinlike growth factor, «both of [which] promote inflammation and both lead to cancer cell division,» says Abrams, who is also professor of clinical medicine at U.C.S.F., and chief of hematotology / oncology at San Francisco General Hospital.

The researchers used a drug called clorgyline to inhibit the activity of the MAOA enzyme; the drug disrupted the signaling system that led to cancer cell invasion and proliferation.

The new chimera interferes with HER2 and HER3 signaling and ultimately leads to cancer cell death, as shown in the group's recent publication in Molecular Therapy: Nucleic Acids.

Turning off the pathway can trigger cancer cells to self - destruct because the machinery used to untangle the DNA fails, meaning it is torn apart as the cell divides — ravaging and causing huge breaks in the code which lead to the cancer cells» demise.

The dendrimer, an extremely tiny nanoparticle, takes advantage of certain physical characteristics that blood vessels leading to cancer cells have, but healthy ones do not.

The scientists looked at this model and found it comes with a major caveat — instead of getting slower over time, some cells start growing at a faster rate as they age, which can result in mutations that lead to cancer cells.

According to researchers at UCLA's Jonsson Comprehensive Cancer Center, this activates a metabolic communication and amplification loop that ultimately leads to cancer cell death.

Not exact matches

The wrong set of changes to a single cell's genetic code, combined with other system breakdowns, can lead to cancer.

The cancerous cells win out over the healthy blood cells in the bone marrow, which in turn leads to kidney problems when the cancer cells make abnormal proteins instead of antibodies.

JCAR017 uses a defined CD4: CD8 cell composition and 4 - 1BB as the co-stimulatory signaling domain to mimic a «second signal» that amplifies the activation of CAR T cells, which according to Juno leads to a more robust signal to the T cell to multiply and kill the cancer cell.

April 16 Merck & Co's immunotherapy Keytruda plus chemotherapy significantly improved overall survival versus chemotherapy alone in newly - diagnosed patients with advanced non-small cell lung cancer in a highly - anticipated study that appears to cement the company's lead in the most lucrative oncology market.

Cambridge, MA — February 6, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that the U.S. Food and Drug Administration (FDA) has cleared the investigational new drug application (IND) for the company's lead program, light - activated AU - 011 in ocular melanoma (OM).

... In lung cancer cell lines, CBD upregulated ICAM - 1, leading to...

ORAC scores measure the ability of antioxidants to absorb free radicals (that come from pollution and toxins in our environment), which cause cell and tissue damage and can lead to diseases such as cancer.

Those chemicals damage cells, promote widespread internal (and invisible) inflammation, and lead to a vast number of health concerns now considered common such as cardiovascular disease and cancer.

But in those cases where it doesn't, and isn't treated, it can lead to pre-cancerous cells which may develop into cervical cancer.»

A 2013 study by Cheryl Watson at The University of Texas Medical Branch at Galveston found that even picomolar concentrations (less than one part per trillion) of BPS can disrupt a cell's normal functioning, which could potentially lead to metabolic disorders such as diabetes and obesity, asthma, birth defects or even cancer.

One study found that a minuscule amount of the stuff messes with a cell in ways that could lead to diabetes, asthma, or cancer.

Improved understanding of the biology of cancer cells has led to the development of biological agents that mimic some of the natural signals that the body uses to regulate growth.

She demonstrated that early experience leads to lasting changes in the molecular structure of the brain and discovered a gene involved in the spread of brain cancer cells into healthy brain tissue.

«These chemicals may lead to new cancer treatments if we can find ones that are more potent to cancer cells than normal healthy cells.

«Once this novel tumor - homing agent binds to the EphA2 receptor, the oncogene functions as a cancer - specific molecular Trojan horse for paclitaxel, carrying the drug inside the cancel cell, killing the cell, and thwarting metastasis,» said Maurizio Pellecchia, a professor of biomedical sciences at UCR's School of Medicine who led the research.

A group of the nation's leading cancer research scientists and their Cuban counterparts are exploring how to advance cancer therapy, diagnosis, and prevention, including the use of immunotherapy to harness the body's immune systems to attack and eliminate cancer cells.

PTEN is known as a tumour suppressor gene meaning that it typically slows the growth of cells and its loss can lead to cancer.

Joe W. Ramos, PhD, deputy director of the UH Cancer Center and collaborators focused on investigating how these oncogenes and related signals lead to dysregulation of normal processes within the cell and activate highly mobile and invasive cancer cell behCancer Center and collaborators focused on investigating how these oncogenes and related signals lead to dysregulation of normal processes within the cell and activate highly mobile and invasive cancer cell behcancer cell behavior.

By studying human cancer cells and animal models of cancer in the lab, our researchers have shown that loss of PTEN leads to high levels of PI (3,4) P2, which could result in hyperactivation of AKT.

It also sought to match epigenetic changes and genetic differences to the physical characteristics of each cell type and use this knowledge to understand how these can lead to blood disorders, cancer and other complex diseases.

In a revolutionary first, Cancer Research UK - funded scientists will test whether the Zika virus can destroy brain tumour cells, potentially leading to new treatments for one of the hardest to treat cancers.

Chronic alcohol consumption causes abnormal fat accumulation in liver cells (steatosis) and liver fibrosis, which can lead to hepatitis, cirrhosis, and sometimes liver cancer.

The problem is that when T cells are allowed to attack, they can destroy both cancer cells and healthy cells, leading to a wide array of side effects.

«Imagine if we could create circuits that detect defects in cancer cells and then turn on pathways that lead to the death of those cells,» he says.

Natural killer cells — which destroy cancer cells and pathogens — also help early fetuses grow, a finding that may lead to treatments to prevent miscarriage

Led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), the retrospective study suggested that a pattern of molecules called microRNA (miRNA) in tumor cells might predict patients» response to radiation therapy.

Engineers are well - equipped to sketch so - called wiring diagrams of biochemical pathways that lead to aberrant cancer cells.

Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.

The ability for cancer cells to develop resistance to chemotherapy drugs — known as multi-drug resistance — remains a leading cause for tumor recurrence and cancer metastasis, but recent findings offer hope that oncologists could one day direct cancer cells to «turn off» their resistance capabilities.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

If these processes are defective, cells acquire the wrong identity — which can ultimately lead to cancer.

A team led by Lu You, an oncologist at Sichuan University's West China Hospital in Chengdu, plans to start testing such cells in people with lung cancer next month.

Researchers at Roswell Park Cancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast cCancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast ccancer cells that leads to chemotherapy resistance in inflammatory breast cancercancer.

«Knowing these cells are leading to increased cancer risk may allow us to find drugs to keep mature cells from starting to divide and multiply,» Mills said.

Cancer stem - like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumour recurrence and metastasis (regrowth).

«But it appears when mature cells return back into a rapidly dividing stem cell state, this creates problems that can lead to cancer.»

An example of epigenetic modifications leading to cancer progenitor cell formation possibly occurs in leukemia development.

A comparison of these two cancers, published April 9 in the journal Cancer Cell, suggests that they are similar in origin, leading researchers at the University of Cambridge to believe that devils simply may be at greater risk for these kinds of diseases.

Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environment.

This leads to massive DNA damage that can not be repaired, and the cancer cells self - destruct.

By using «gemcitabine» chemotherapy to target cancer cells, and a form of vitamin A to target the surrounding stromal cells, the combined approach led to a reduction in cancer cell proliferation and invasion.