Sentences with phrase «lead to significant»

Most aspects of agricultural work lead to significant exposures.

Coral bleaching events that lead to significant coral mortality can drive large shifts in fish communities.

Deterioration and loss of lower motor neurons that innervate skeletal muscle lead to significant muscle atrophy, particularly in fast - twitch fibers.

The compounds have been shown in vitro and in vivo to upregulate SMN levels in cells and tissues and to lead to significant improvements in survival and motor function in mouse models.

If confirmed, the findings will open a new line of research that could ultimately lead to significant innovation, as drugs that control amounts of the novel mucins could be a new treatment paradigm for glaucoma.

If confirmed, the findings will open a new line of research that could ultimately lead to significant innovation, as drugs that control amounts of the novel mucins or that target specific glycosylating enzymes could lead to a new treatment paradigm for glaucoma.

Our data suggest that changes in the expression of genes associated with drug resistance and cancer cell «stemness», induced by treatment with MIA - 602, lead to a significant reduction in the efflux capacity of drug resistant cells.

A forthcoming paper from the Stockholm Environment Institute and EarthTrack shows that in the US, in particular, production subsidies can spur otherwise uneconomic investment, lead to significant added emissions, and also transfer taxpayer resources to company profits.

Scientists have long feared that as the world gets warmer, thawing permafrost may lead to a significant effect on global warming.

Dr Sarah Teichmann, co-chair of the HCA Organising Committee and Head of Cellular Genetics at the Wellcome Sanger Institute, said: «Our understanding of human development will be transformed by the HDCA project and could lead to significant advances in biology and medicine.

UCSF researchers have tackled a decade - long scientific conundrum, and their discovery is expected to lead to significant advances in using stem cells to treat genetic diseases before birth.

A better understanding of how reward and risk affect our decisions could lead to significant health benefits in the long term.

Not only will the technology used in this project lead to a significant increase in the understanding of Gentoo penguin foraging ecology, but it is also hoped that the medium of video will help promote awareness of this species, other marine species and the importance and fun of research in society today.

The continued increase in the atmospheric concentration of carbon dioxide due to anthropogenic emissions is predicted to lead to significant changes in climate1.

«We hope our contributions could lead to significant scientific results with ALMA.

I think you need to state clearly that a consensus exists around the idea that increased CO2 will lead to significant warming.

To carry out projects in genome analysis that will lead to significant improvements in people's health and quality of life, in collaboration with the Catalan, Spanish, European and International research and clinical community.

The research ideas you develop at the workshop should: • Lead to the significant advancement of our understanding of sensor technologies suitable for liquid biopsy • Consider the practical challenges of low volume liquid usually taken for analysis and the inconsistency of sample preparation across point of care sites • Prioritise biomarkers with high specificity for cancer or even for multiple cancer types, including markers specific to cancers that will become aggressive as opposed to non-lethal disease

Each of the working groups is responsible for developing a proposal for a set of genomes to sequence that would advance knowledge in one of three important scientific areas: identifying areas in genetic research where the application of high - throughput sequencing resources would rapidly lead to significant medical advances; understanding of the human genome; and understanding the evolutionary biology of genomes.

Moreover, loss of myostatin activity resulting either from postnatal inactivation of the Mstn gene [3], [4] or following administration of various myostatin inhibitors to wild type adult mice [5]--[7] can also lead to significant muscle growth.

Such a shortfall is particularly prominent in luminous infrared galaxies (LIRGs), which have high star formation (and thus CCSN) rates and host bright and crowded nuclear regions, where large extinctions and reduced search detection efficiency likely lead to a significant fraction of CCSNe remaining undiscovered.

Higher frequencies and shorter treatments did not lead to significant damage of the graphene oxide flakes and produced larger scrolls, while low frequencies and longer treatment times tended to cleave flakes apart and create smaller scrolls.

The collapse of Larsen C itself will not lead to significant sea - level rise, but it could be a signal that other major changes are on the way.

The challenge will be seeing eye to eye on the reasons each country supports this action — the U.S. because of its potential carbon savings and Indonesia because the fires caused by clearing lead to significant health and economic threats.

«We're confident that this collaboration will lead to a significant portfolio of new sensors.»

But their arguments did not lead to significant changes.

To top that off, they learned there's a delay before zinc impacts ganglion cells, which means that chelation could lead to significant cell survival and regeneration even if treatment was delayed for several days.

About 20 % of eRA's contractor staff must be released as a result of the cutback, which will lead to a significant impact on the services that eRA provides to the extramural community.

A research advance co-led by Case Western Reserve University School of Medicine's Kumar Alagramam, PhD, may stop the progression of hearing loss and lead to significant preservation of hearing in people with Usher syndrome type III, a form of hereditary hearing loss linked to defects in the sensory «hair» cells in the inner ear.

Like next - generation robotics, improved AI will lead to significant productivity advances as machines take over — and even perform better — certain human tasks.

One of the main risk factors for CVD is age, so under treating older adults may lead to a significant increase in CVD events.

These hotspots lead to a significant increase in noise, something we confirmed using simulations.»

Eating a non-calorie restricted Mediterranean diet high in vegetable fats such as olive oil or nuts does not lead to significant weight gain compared to a low - fat diet, according to a large randomised trial published in The Lancet Diabetes & Endocrinology journal.

«Computation, collaboration lead to significant advance in malaria.»

«A heavy reliance on certain plant foods well before people started to rely on cultivated plants could, in certain circumstances, lead to significant [tooth decay] levels,» says Marijke van der Veen of the University of Leicester, UK.

If scaled nationally, group prenatal care could lead to significant improvements in birth outcomes, health disparities, and healthcare costs,» she added.

A new study by University of North Carolina at Chapel Hill researchers finds that a collection of simple strategies used by parents can lead to significant improvements in one - year - olds at risk for autism spectrum disorder (ASD).

A highly directional single photon source could lead to a significant progress in producing compact, cheap, and efficient sources of quantum information bits for future quantum technological applications,» said Prof. Ronen Rapaport, of the Racah Institute of Physics, The Department of Applied Physics, and the Center of Nanoscience and Nanotechnology at the Hebrew University of Jerusalem.

The combination of advances in modelling and much better data from telescopes like the James Webb Space Telescope is likely to lead to significant progress in this exciting field.

That will eventually lead to significant reductions in use of animal testing.

People with low incomes and racial / ethnic minority populations experience greater levels of stress than their more affluent, white counterparts, which can lead to significant disparities in both mental and physical health that ultimately affect life expectancy, according to a report from the American Psychological Association.

He said: «Previous research has shown that visual search training can lead to significant recovery of sight following damage to visual centres of the brain in adults.

The researchers argue that adopting such a policy could lead to significant public health risks.

It would read and understand scientific literature, connecting the dots between studies and suggesting hypotheses that could lead to significant breakthroughs.

«On the basis of our study findings, we have two important take home messages: First, even though losing half a night of sleep may not impair memory functions under baseline conditions, the addition of acute cognitive stress may be enough to lead to significant impairments, which can possibly be detrimental in real - world scenarios.

In the United States, reducing electricity probably won't lead to a significant reduction in direct oil consumption.

Rolling back environmental regulations will not lead to a significant resurgence of the coal industry because those regulations played only a minor role relative to slowing demand for electricity and a surge in cheaper, cleaner sources of energy.

Around one sixth of people in the UK aged over 75 have vitamin B12 deficiency, which when severe can lead to significant problems in the nervous system including muscle weakness, problems with walking, tiredness, and pins and needles, as well as depression and problems with memory and other important everyday cognitive functions.

«Our results indicate that areas of eastern Texas, Florida, the south - east and mid-Atlantic are areas where rapid population growth, acting in concert with a warming climate, will lead to a significant increase in exposure to heat extremes,» says Jones.

Valesky is optimistic that in the coming weeks, negotiations on all sides will lead to a significant election finance reform by the time the term ends in June.