Sentences with phrase «leading abl»

Not exact matches

# 26 Bill Bridges HOBBS Was leading scorer in ABL (29.8 ppg) when it folded midway through 1962 - 63 season; played with Hawks, 76ers, Lakers and Warriors; scored more than 11,000 points.

In a mouse model in which they simulated the development of CML by adding Bcr - Abl to the bone marrow, a shortage of Gab2 led to a clear weakening or even a lack of symptoms.

Therefore, a team led by Vladimir Tesar, MD, PhD (Charles University and General University Hospital, in the Czech Republic) tested the potential of an investigational drug called bosutinib that inhibits a particular tyrosine kinase called Src / Bcr - Abl.

Dr Richard Byers, who jointly led the research, said: «Previous studies have linked high levels of the BCR - ABL mutation with drug resistance.

The activity of tyrosine kinases is typically regulated in an auto - inhibitory fashion, but the BCR - Abl fusion gene codes for a protein that is «always on» or continuously activated leading to unregulated cell division (i.e. cancer).

To evaluate whether ABL kinases might regulate the secretion of osteoblast - derived RANKL or OPG leading to osteoclast differentiation, we analyzed RANKL and OPG mRNA abundance in the murine osteoblast cell line 7F2 in response to conditioned medium from control and ABL1 / ABL2 knockdown breast cancer cells.

Together, these data revealed a functional link between the ABL kinases and TAZ signaling leading to increased AXL abundance in breast cancer cells, and identified a potentially druggable pathway for the treatment of breast cancer bone metastasis.

This discovery led him to evaluate second generation Abl kinase inhibitors, such as the dual Src / Abl inhibitor dasatinib, which received fast - track approval at the FDA in June 2006.

This work, and that of colleagues Brian Druker and Novartis, led to the development of the kinase inhibitor imatinib (Gleevec) as primary therapy for chronic myelogenous leukemia (CML), and the discovery that imatinib resistance is caused by BCR - ABL kinase domain mutations.

To support its pioneering efforts to simplify the master scheduling process, education technology startup Abl today announced $ 7.5 million in Series A funding, led by Rethink Education.

With approximately 125 fee - earners, ABL enjoys long - standing relationships with many of Australia's leading corporations and private family groups, managing a wide variety of significant and complex matters on behalf of their clients.