DOYLESTOWN, Pa. (October 2015)-- The Baruch S. Blumberg Institute, established by the Hepatitis B Foundation to fulfill its research mission, is pleased to announce the creation of the W. Thomas London Distinguished Professorship and its inaugural presentation to
leading hepatitis B researcher Dr. Ju - Tao Guo.
Dr. Guo is a leader in the field of hepatitis B research and worked closely with Dr. London and other
leading hepatitis scientists at the Fox Chase Cancer Center prior to joining the Blumberg Institute.
«We desperately need a culture system,» says Frank Chisari,
a leading hepatitis immunologist at The Scripps Research Institute in La Jolla, California.
Not exact matches
Chronic alcohol consumption causes abnormal fat accumulation in liver cells (steatosis) and liver fibrosis, which can
lead to
hepatitis, cirrhosis, and sometimes liver cancer.
Cirrhosis is most commonly caused by alcoholism and
hepatitis C, and was the 12th
leading cause of death in the United States in 2000.
«We've been here before,» says Stefan Wiktor, head of the global
hepatitis program at the World Health Organization (WHO) in Geneva, Switzerland, and
lead author of the guidelines (see go.nature.com/bwhguw).
Although the bacterium normally causes a skin infection, MRSA can be fatal when it
leads to more invasive infections, such as pneumonia, sepsis and meningitis — causing more deaths in the U.S. than HIV, viral
hepatitis and tuberculosis combined.
No vaccine has been developed to protect patients from the
hepatitis C virus, which is spread through blood and can
lead to liver failure and death if untreated.
A new drug is offering dramatic cure rates for
hepatitis C patients with two subtypes of the infection — genotype 2 and 3, say a team of scientists
led by Weill Cornell Medical College researchers.
Worldwide, an estimated 120 to 150 million people have chronic
hepatitis C. Left untreated, the infection can
lead to cirrhosis, liver failure, and liver cancer.
«The new sofosbuvir therapy offers a much - needed alternative to standard therapy with interferon, which can cause significant side effects for
hepatitis C patients,» says the study's
lead investigator, Dr. Ira Jacobson, chief of the Division of Gastroenterology and Hepatology and Vincent Astor Distinguished Professor of Medicine at Weill Cornell Medical College.
«It is not unusual for patients with
hepatitis C to come in and they have liver cancer, and they didn't even know that they had cirrhosis that
led to their cancer.»
Now they are social as well: growing income inequality in the U.S. has
led to rising rates of
hepatitis A, Legionnaires» disease and other scourges.
The UNC research team,
led by Lemon and Jason Whitmire, Ph.D., Associate Professor in UNC's Department of Genetics, is now poised to investigate the complicated interplay of nonspecific «innate» and specific «adaptive» immune responses that ultimately control the infection and eliminate HAV from the host — processes that are not well understood for any of the five human
hepatitis viruses.
Frozen strawberries used in drinks at a smoothie chain
led to a
hepatitis A outbreak this summer in seven states.
Primary liver cancer is the third
leading cause of cancer death worldwide, and recent studies have shown that particularly in Asia, infection with either
hepatitis B or C is often associated with such cancers.
A lack of adequate sanitation and health care has
led to recurring epidemics of cholera, malaria, typhoid fever,
hepatitis, yellow fever, and aids.
In a letter to the Medical Journal of Australia published today, a Monash University -
led team is asking for
hepatitis C virus patients to gain improved access to drugs to prevent liver related deaths.
Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, called the new work a «significant advance,» noting in a statement that it «opens the way to producing [monoclonal antibodies] that potentially could be used diagnostically or therapeutically» for the flu as well as other infectious diseases such as
hepatitis C and the human immunodeficiency virus (HIV), which can
lead to full - blown AIDS.
Nearly 170 million people worldwide have
hepatitis C infections and one quarter of those cases can
lead to liver disease that leaves the organ scarred and otherwise damaged, he says, adding, «The latest estimate is that in the U.S. five million people have
hepatitis C infections and many people don't even know it.»
«While early diagnosis along with optimal medical therapy offers patients with autoimmune
hepatitis a good prognosis, the disease can be very severe in some cases,» explains
lead author Dr. Arndt Vogel from Hannover Medical School in Hannover, Germany.
«FDA's approach to evaluation of recent
hepatitis C drugs underscores the Agency's flexibility in considering innovative or alternative trial designs for drugs that have demonstrated highly promising outcomes in early phase development,» said Dr. Poonam Mishra, deputy director for Safety, Division of Antiviral Products / Office of Antimicrobial Products in the FDA's Center for Drug Evaluation and Research and
lead author of the Hepatology paper.
Today is the 74th birthday of Baruch Blumberg, an American research physician whose work has
led to blood screening and a vaccine against
hepatitis B.
In industrialized countries, the main causes of liver injury
leading to fibrosis include chronic
hepatitis virus infection, excess alcohol consumption and, increasingly, nonalcoholic steatohepatitis (NASH).
«From a clinical standpoint, we've long known about the devastating health impacts that chronic
hepatitis C has on a patient,» said Zobair Younossi, MD, chairman of the department of medicine at Inova and
lead researcher on the study.
Infection can
lead to chronic
hepatitis, which can progress to liver cirrhosis and carcinoma.
«Under normal circumstances, myofibroblasts stimulate wound healing, but when there's an ongoing injury to an organ (e.g., the liver of a
hepatitis C patient, the heart of a patient with high blood pressure, or the kidney of a patient with diabetes) these proteins clog up normal functioning,» said Humphreys, a Harvard Medical School associate professor at Brigham and Women's Hospital, who
leads the Harvard Stem Cell Institute Kidney Program.
Professor David Goldberg,
lead of the team implementing Scotland's
hepatitis C Action Plan (2008 - 2011), said: «This study demonstrates that, in a country like Scotland which has a Government seriously committed to the improvement of
hepatitis C services, increasing patient access to antiviral therapy could potentially have a major impact in the prevention of transmission of infection.»
For example, the knowledge that a particular genotype decreases the risk for developing chronic
hepatitis C might
lead to an increase in risk - taking behavior.
The liver may, for example, have been weakened by excessive alcohol consumption, obesity, or chronic viral infection by
hepatitis B or C viruses, which causes irreversible liver lesions
leading to cirrhosis.
In the 1980s, he
led trials in Phoenix of a successful vaccine against another killer,
hepatitis B.
After concluding from our proof - of - concept experiment that a successful gesicle - based knockout of a virally integrated gene can be achieved, we chose to target CD81, an endogenous membrane glycoprotein that forms complexes with integrins and plays a critical role in the infection process that
leads to
hepatitis C (Figure 3).
The
hepatitis B virus, which chronically infects more than 240 million people worldwide, causes cirrhosis and is the world's
leading cause of liver cancer.
Soumitri Barua is the
lead author of a study showing that most states in 2013 were rationing
hepatitis C treatment against the recommendations of doctors and possibly against federal law.
«Most of what we work on has some kind of relevance to infectious disease,» says Pyle, who hopes this line of work might
lead to better drugs for treatment of
hepatitis C and other viruses.
His long - term collaboration with Dr. Baruch S. Blumberg, who won the Nobel Prize for his discovery of the
hepatitis B virus,
led to breakthrough epidemiological, clinical, and virological studies of
hepatitis B and its link to primary liver cancer, or hepatocellular carcinoma (HCC).
The Blumberg Institute is fortunate to have attracted Tim Block and his colleagues, positioning the nonprofit institute to maintain its world - class stature in
hepatitis research,» said Dr. Tom Shenk, one of the nation's
leading virologists, a professor at Princeton University, and a member of the Foundation's Board of Directors.
About the
Hepatitis B Foundation: The
Hepatitis B Foundation is the nation's
leading nonprofit organization solely dedicated to finding a cure for
hepatitis B and improving the quality of life for those affected worldwide through research, education and patient advocacy.
Unless treated properly, inflammation from chronic
hepatitis can
lead to cell damage and, eventually, liver cancer.
There are more than one billion people on the planet who have been infected with
hepatitis B and it's the
leading cause of liver cancer in the world, says Dr. Dieterich.
In fact, out of 22 fruits tested, avocados performed the best at reducing laboratory - induced liver damage in rats,
leading the research team to conclude that avocados could offer a promising therapy for
hepatitis.
This herb is no better for the liver than senna, as it contains anthracene glycoside, a compound that can
lead to
hepatitis and liver failure.
Due to an inflammation of the liver with
hepatitis viruses A, B, and C can
lead to light colored stool.
Hepatitis C is the type of viral
hepatitis which often
leads to liver diseases, affecting the normal function of the liver, including bile production.
It protects your puppy from
leading infections and illnesses, including distemper,
hepatitis, leptospirosis, parvovirus and parainfluenza.
This
leads to more preventive medicine such as heartworm prevention and vaccines for diseases like canine distemper, parvovirus,
hepatitis, rabies, feline panleukopenia, and rhinotracheitis.
Untreated copper - storage hepatopathy can
lead to cirrhosis of the liver, chronic
hepatitis or even liver failure.
Although
hepatitis is a very serious disease, not all cases of CAV - 1 infection
lead to it and not all are serious.
Other diseases that can
lead to chronic active
hepatitis are infectious canine
hepatitis, leptospirosis, autoimmune disease and drug and chemical toxicities.
Canine Adenovirus Type 1 & Type 2 Canine Adenovirus Type 1 infection causes infectious
hepatitis and may
lead to severe kidney damage.