Sentences with phrase «leading to cancer development»

It is known that cells without this type of DNA repair can develop mutations leading to cancer development.

This phenomenon could result in breakage in the human genome, and when a breakage impacts important genes, such as tumor suppressors, it could lead to cancer development.

While the tendency to develop cancer may be inherited in some pets, there are many environmental factors that may trigger the genes that lead to cancer development.

Not exact matches

Certain strains of the virus, which is sexually transmitted, are known to lead to the development of cervical cancer, as well as to cancers of the genitals, anus, and oropharynx (the part of the throat that lies just behind the mouth).

Her discovery of radium lead to the development of using X-rays in medicine, and Curie was at the forefront for cancer research, directing the first studies that used radiation to treat tumors.

For kids, many parents also try to avoid products with bisphenol - A (BPA) because of concerns about its potential to mimic estrogen, lead to reproductive problems, increase the risk of cancer and interfere with brain development and fat metabolism.

Since 2008, the use of BPA in baby bottles has dropped out of favor with manufacturers, since BPAs have been associated with leading to certain cancers, disruptive to brain development and the reproductive system, including early onset of puberty.

Extreme estrogen sensitivity can lead to fertility problems, advanced puberty, altered mammary development and reproductive function, as well as a variety of hormone - related cancers.

Improved understanding of the biology of cancer cells has led to the development of biological agents that mimic some of the natural signals that the body uses to regulate growth.

When CSN6 is overexpressed via ERK2 in particular, however, it can lead to deregulation of another protein, beta - catenin, a transcription factor known to be linked to cancer development.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tCancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tcancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

That can lead to the development of precancerous lesions and, potentially, cancer.»

Dr. Storz's research team traced the pathway leading from inflammation in the pancreas to development of cancer in the organ.

It is highly associated with obesity and diabetes, and is one of the reasons for concern over the increasing rates of both problems in the U.S. NASH can lead to cirrhosis and to hepatocellular carcinoma (liver cancer), so understanding its development is becoming more and more important.

An example of epigenetic modifications leading to cancer progenitor cell formation possibly occurs in leukemia development.

«Programming DNA to deliver cancer drugs: New technology could lead to the development of new cancer therapies.»

As co-director of the institute and director of technology development, Mardis leads teams that are using genome science to transform the diagnosis and treatment of cancer.

Published in the journal Cancer Research, the discovery has potential to lead to the development of a blood test that could predict whether cancer will spread from the prostate tumour to other parts of theCancer Research, the discovery has potential to lead to the development of a blood test that could predict whether cancer will spread from the prostate tumour to other parts of thecancer will spread from the prostate tumour to other parts of the body.

Scientists discovered in the early 2000s that deregulation of microRNAs can lead to the development of cancer.

The work published in Cancer Cell complements previous research efforts from the CNIO Melanoma Group, which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic strategy.

«The phi test helps physicians distinguish prostate cancer from benign conditions by utilizing three different PSA markers (PSA, freePSA and p2PSA) as part of a sophisticated algorithm to more reliably determine the probability of cancer in patients with elevated PSA levels,» said Kevin Slawin, MD, director, Vanguard Urologic Institute at Memorial Hermann Medical Group, clinical professor of Urology at Baylor College of Medicine and director of Urology, Memorial Hermann Hospital ‐ Texas Medical Center, who performed some of the key research that led to the development of the phi test and who also began using the test in February.

The study, «The nuclear transport receptor Importin - 11 is a tumor suppressor that maintains PTEN protein,» which will be published online February 13 in The Journal of Cell Biology, suggests that the loss of Importin - 11 may destabilize PTEN, leading to the development of lung, prostate, and other cancers.

Meanwhile, cancer genome projects have yielded unprecedented insights into the cellular signaling pathways that drive the development and progression of cancer — information that has led to effective therapies tailored for individual patients.

«This model supported cancer development so strongly that some mice developed invasive squamous cell skin cancers similar to the patient's tumor,» said lead author Shadmehr Demehri, MD, PhD, a dermatologist and postdoctoral fellow.

The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected prcancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected prCancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected prcancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.

If the DNA is not repaired, cells may begin growing uncontrollably, leading to the development of cancer.

This makes the development of an effective vaccine to protect against infection, as well as antiviral therapy to combat already - existing infections, particularly challenging,» says Dr. Grant Hansman, a virologist who leads the CHS Research Group on Noroviruses at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and Heidelberg University.

For example, such an approach might eventually form the basis for treating the most common cause of infertility — the failure of the embryo to successfully implant — or for affecting the cellular changes that lead to the development of cancer.

Consuming a high - fat, high - sugar diet and having excess body fat is linked with the development of NAFLD, which can lead to diseases such as cirrhosis and liver cancer.

«The biggest issue will be price,» says John Schiller, a senior investigator at the National Cancer Institute, who did some of the early work that led to the vaccine's development.

«This new finding may lead to the development of miR - 34a mimics as a new and better treatment for osteoporosis and cancers that metastasize to the bone,» said senior author Dr. Yihong Wan, Assistant Professor of Pharmacology and member of the UT Southwestern Harold C. Simmons Cancer Center.

A new study from the University of Illinois reports that including broccoli in the diet may also protect against liver cancer, as well as aid in countering the development of fatty liver or nonalcoholic fatty liver disease (NAFLD) which can cause malfunction of the liver and lead to hepatocellular carcinoma (HCC), a liver cancer with a high mortality rate.

Scientists at Cold Spring Harbor Laboratory (CSHL) today report a discovery that they hope will lead to the development of a powerful new way of treating an aggressive form of breast cancer.

«We need to see how these stem cells are both working together to heal, or how they are damaged that leads to the development of colon cancer.»

«Sleep disorders, such as sleep apnoea, impact on a wide variety of chronic conditions, potentially leading to their development or worsening them, including diabetes, heart attacks, strokes and possibly even cancer.

His discovery led to the development of a vaccine against cervical cancer.

«More people than ever are surviving cancer due to the development of targeted and effective treatments,» said Shelley Johns, Psy.D., the clinical health psychologist and health services researcher who led the Regenstrief - IU study.

Now his lab has found that Set2 is also a major player in DNA repair, a complicated and crucial process that can lead to the development of cancer cells if the repair goes wrong.

This led to development of newer technology, called single cell sequencing (SCS), that has had a major impact in many areas of biology, including cancer research, neurobiology, microbiology, and immunology, and has greatly improved understanding of certain tumor characteristics in cancer.

Before assuming the post as UCSF chancellor in 2009, Desmond - Hellmann was president of product development at pre-Roche Genentech «during some of the biotech's most fruitful years,» according to FierceBiotech, leading the introduction of the targeted cancer drugs Avastin and Herceptin.

According to Robert Weinberg, a leading cancer researcher and founding member of the Whitehead Institute in Cambridge, Massachusetts, a number of «built - in native defenses» usually prevent the development of cancer.

Given the slow growth of prostate cancer development, this investigation offers novel and important information to physicians, patients and the general public,» said lead author Jacques Baillargeon, UTMB professor of epidemiology in the department of preventative medicine and community health.

In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers — triple negative breast cancer.

This allows the researchers to observe how cells work within these environments and potentially enables them to study biological scenarios such as where cancer grows or how immune cells interact with other cells, which could lead to the development of new drugs.

Now, researchers from the Perelman School of Medicine, University of Pennsylvania have shown that when the enzyme key to cutting and pasting segments of DNA hits so - called «off - target» spots on a chromosome, the development of immune cells can lead to cancer in animal models.

Additional studies have shown that this process may also lead to the development of cancer in the liver and the bladder.

«Aberrant splicing in humans may lead to various complex diseases and also underlies the development of some forms of cancer and the onset of neurodegenerative diseases, so a better understanding of the process can add important information for our fight against these diseases.»

«One of the most common viruses in humans may promote breast cancer development: Findings could lead to new prevention strategies.»

However, lingering infections with a subset of about 19 «high - risk» HPV types can lead to the development of cervical cancer or other genital / anal cancers.