This process typically includes assay development, high throughput screening, identification of «hits» that have activity in a test tube (or assay), characterization of hits and selection of
leads for further optimization.
«Our study uncovers the first genetic evidence explaining why some people look older for their age,» write the authors of the paper, in the latest issue of the journal Current Biology, «and provides new
leads for further investigating the biological basis of how old or young people look.»
Taken together, these data suggest that indole derivatives, although their IC50 values are in the micromolar range, represent functional
leads for further development of novel CXCR4 antagonists useful in medicinal chemistry programs.
Then, once you have your leads ranked and prioritized, you can focus on the most urgent sales leads that seem most likely to convert, while discarding the leads that are not serious buyers, and most importantly, saving the promising «long - range»
leads for further databasing, lead nurturing and follow - up.
Howard described it as a «near - death experience» and went on to
lead for a further nine years.
San Marino held
the lead for a further 20 minutes, which for a team with (at the time) precisely no victories in international football was more or less remarkable.
Not exact matches
However, the distribution of the UKIP vote may
lead to the Tories» piling up votes in areas where they are too
far behind Labour
for it to make a difference.
In 1998, the Council of the European Union passed a directive that set rules
for the protection of farmed animals — a directive updated in 2009 that
led to
far more ethical treatment of animals there.
«This current funding round sets the stage
for us to
further invest in expanding our
lead in the sector in areas like automation, drones and robotics,» Richard Liu, chairman and CEO of JD.com, said in a statement Wednesday.
While it's unclear so
far which group, exactly, will be
leading the charge, Inc. has confirmed the existence of at least one: BayShare, which describes itself as an «advocacy organization in the San Francisco Bay Area whose mission is to make the Bay Area the best place on the planet
for sharing.»
French food group Danone kept its guidance
for a
further rise in profits and sales this year after first quarter underlying sales growth beat market expectations,
led by strong demand
for baby formula products in China.
«This was everything that I had been wishing
for and working towards and all of the little building blocks and progression in my career so
far felt like they were
leading to this.»
Inc. in March to
further develop its
leading chronic pain drug, NMED - 160, a research deal that could eventually be worth close to $ 500 million
for Neuromed.
Of course, most business leaders were firmly
for staying in the EU, so they can't be faulted
for their immediate role in the referendum, but according author Umair Haque, writing on the HBR blogs, those who
lead the country's companies are very
far from blameless.
If Japan's central bank continues to suppress 10 - year yields in Japan, that could
lead to
further yen weakness, which would be good
for their exporters.
Successful restructuring of operations at the company's Casposo mine in Argentina by experienced local partner Austral Gold Limited may also
lead to a
further cash inflow
for Troy as Austral have the right to gradually increase their equity in that project over time.
«The entrepreneur was able to combine both approaches successfully, with the discounted offerings being the basis
for establishing the relationships with clients,
leading to
further deals,» Osiyevskiyy explains.
It «sharply weakens and probably
leads to eventual disintegration of the UK» and «also ends
further EU integration,» he said, «while the Brits need to be maximally punished by EU countries to ensure there isn't a path
for further exit.»
What will happen over the next few months
leading up to the election will have
far - reaching effects, not just
for American public policy but
for global leaders, business executives and foreign policy throughout the world.
Mehta has words of advice
for the new AI entrants, he states that following the below mentioned approaches, startup owners could gain confidence while dealing with
leading venture capitalists as
far as raising post-Series A funding is concerned:
That can
further limit the potential
for drug interactions or other complications, and
lead to better care.
According to Scotiabank's Derek Holt, who predicts household grocery bills could balloon by as much as 15 % in the next few years, the failure of the international community to settle on a rational policy
for handling shortages has
led to stockpiling and export bans, which «
further impairs supply sides of markets and causes prices to go up even more.»
There has been a slew of bad news over the past month
for the
leading daily fantasy sports companies, but the latest may be the most significant blow so
far.
But Mike Elleman, a
leading missile expert, wrote on 38 North, a website
for North Korea analysis, that despite the missile's size it still probably couldn't send a heavy nuclear warhead as
far as the US's east coast.
«The fact that we have seen over # 1 billion worth of venture capital investment into London fintech companies since the EU referendum vote offers
further proof that global investors still believe London will remain a
leading fintech hub
for many years to come,» Rajesh Agrawal, London's deputy mayor
for business, said in a statement Thursday.
Which has
led to the installation of ridiculous props in the workplace to make it seem like the work environment is something that it's not: an arcade machine in the corner, a bar and barista by the
far wall, big chalkboards or dry erase boards around the office
for Millennial employees to write inspirational quotes on.
While New Zealand's official cash rate is already at a record - low 2 % after the latest cut in August, it is still the highest in the developed world — a major draw
for yield - hungry investors and a complication
for the central bank as a higher kiwi
further dampens imported -
led inflation.
«The determination of the PSD -
led government to charge ahead with the contentious criminal justice reform in disregard of widespread public discontent and political opposition sets a scene
for tumultuous period ahead, highlighting a risk of
further deteriorating operating environment,» Andrius Tursa, advisor on central and eastern European issues at Teneo Intelligence said in a note last week.
This is, by
far, gun violence, by
far the
leading cause of death
for young African - American men outstripping the next nine causes of death combined.
This week's announcement of the merger of America's two
leading chemical companies, DuPont (DD) and Dow (DOW), could spell doom
for DuPont's central research labs and presages
further research cuts at Dow as well.
While the results can't conclusively prove that all those second screens are causing the changes to the brain (differences in brain structure could also
lead people to be more likely to multitask), the researchers suggest that the results should nonetheless serve as a red flag
for fans of multiple devices while
further studies are carried out to test causality.
If you feel the need
for leads but don't have the dough to exhibit in
far - flung trade shows, go virtual.
The US saw the biggest increase in private equity transactions with a 52 percent rise in deals
led by buyout funds, accounting
for a total of $ 46.4 billion so
far this year.
The incident
led to
further accusations of past plagiarism by Biden, and he ultimately withdrew from the race
for the Democratic nomination
Although revenues
for the group rose 3.8 percent, expenses rose
further, up 8.1 percent,
led by labor (up 8.1 percent) and fuel (up 17 percent).
The Republican -
led Congress has struggled immensely over the past eight months, and the party now faces
further division as they return and urgently need to raise the debt ceiling to avoid a government shutdown, pass an aid package
for Hurricane Harvey — some of which is expected to be tied to the raise of the debt ceiling — and now reach a decision on DACA.
«This partnership with MaRS is a natural fit
for Hydro Ottawa as we continue to drive
for performance excellence, while
furthering our goal to be Canada's
leading electricity company of tomorrow.»
With
leading stocks ripping to new highs every day, you now have a clear and objective way
for filtering out the stocks that could still be considered
for buy entry, versus those that are too
far gone.
«These exciting new anchor tenants align directly with MaRS» mandate and will
further Ontario's position as a global leader in life sciences,
leading to tangible medical benefits
for Ontarians while taking advantage of a massive economic opportunity.»
With the founding of Crypto Valley Association, we are promoting more than a region: we have founded a global association as a base
for the sector's most innovative and forward thinking companies,
further strengthening Switzerland's position as a
leading centre of innovation in this sector,» said Oliver Bussmann, President of the CVA.
Further, BC has been a net and often a
leading contributor to transfer payments
for decades with few exceptions.
The European Union is, after all, an economic superpower in its own right —
far too big and rich
for America to have much direct influence —
led by sophisticated people who should be able to manage their own affairs.
The Morgan Stanley report
further explained that «credit markets figure this out before equities» and that they are preparing «
for a deterioration in lower - quality earnings in the U.S.
led by lower operating margins.»
The lifelong quest
for knowledge of the world and self — not to mention gainful employment — has
led me near and
far afield, from Europe, across the Asia - Pacific, Middle East and Africa and back home to the Americas.
The Marketing Machine works with you and / or your marketing department to go
farther; to
lead with an idea, not a media plan; and we will present you with a customized deployment strategy that makes perfect sense
for your brand and budget.
While the government dollars may save jobs
for a while, eventually the same pressures will
lead companies to ask
for further concessions.
«Because of our long bias, this has
led us to hold
far more cash than we would like, and more than we have done so
for the previous decade.
So
far the fall has also not been good to the Finance Minister and, unfortunately, it is unlikely that the months
leading up to the 2018 budget will get any better
for him.
«If this
leads to a larger discount in tight oil grades,
further incentivizing domestic processing, the U.S. may be set up poorly
for strengthening distillate demand later in the year.»
The bustling seaside biotech hub
led the rankings
for its exceptional startup density, which fell
far above the report average.