Now, University of Pennsylvania researchers have revealed how a reduction in mitochondrial DNA content
leads human breast cancer cells to take on aggressive, metastatic properties.
Aug 8, 2008 Two New Predisposition Genes For
Breast, Thyroid And Kidney
Cancers Could
Lead to More Accurate Diagnosis and Earlier Detection of These
Cancers Charis Eng, MD, PhD, Sondra J and Stephen R Hardis Endowed Chair of
Cancer Genomic Medicine and Chair, GMI, and her team published in the Aug 8, 2008 issue of the American Journal of
Human Genetics that germline mutations in SDHB and SDHD, which play key roles in the mitochondria (the
cell's power houses), predispose to Cowden and Cowden - like syndromes.
A recent study out of Georgetown University showed that the metals mercury, copper, cobalt, nickel,
lead, tin, chromium and vanadate activated estrogen receptor alpha sites in
human breast cell cancer lines in ways similarly to the
human estrogen estradiol.