Sentences with phrase «leads on genes»

In recent years DNA - and RNA - based surveys of tumor genome and expression profiling have produced a plethora of leads on genes with clinical significance.

In the September issue of G3, Cuomo et al. unveil the first whole - genome sequence of a clinical sample of C. krusei, providing leads on genes that may be important for the species» fluconazole resistance.

Not exact matches

Advances in molecular biology and bioinformatics have led to an explosion of research on the causes of hearing loss and how to fix it with drugs or gene therapy.

Angling to be the go - to marketplace for these gene - based businesses, Helix, the spin out from genetic testing research and technology giant Illumina, has held a first close on a planned $ 200 million funding round led by new investor DFJ Growth.

And on the subject of public health, it is worth exploding the number one myth of anti-GM lobbyists that the antibiotic resistance genes carried by some GM crops might lead to devastating human epidemics if transferred to bacteria.

Decathlon, in first start as 3 - year - old, slogged through mud into early lead, held on grimly under urging of Jockey Gene Martin to nose out Liberty Sun in $ 23,775 Hibiscus Stakes at Hialeah Park, Fla..

The Broncos had led 3 - 2 at half time on Gene Mingo's 52 - yard field goal.

The study, led by Dr Len Stephens and Dr Phill Hawkins and published today in the journal Molecular Cell, reveals why loss of the PTEN gene has such an impact on many people with prostate cancer, as well as in some breast cancers.

«Our aim was to explore the effect of a more acidic ocean on every gene in the coral genome,» says study lead author Dr Aurelie Moya, a molecular ecologist with the ARC Centre of Excellence for Coral Reef Studies at James Cook University.

The UNC collaborators on the study team, led by Timothy C. Nichols, MD, performed gene therapy experiments using the well - established dog colony at their institution.

University of Adelaide School of Molecular and Biomedical Science PhD student, Deborah Toledo - Flores, says: «the most important aspect of this work for us was to identify more genes on platypus Y chromosomes to reveal new leads about potential sex determining genes in these animals.»

This led Pembrey to suspect that genes on the sex - specific X and Y chromosomes were being affected by epigenetic signals.

When the researchers compared the mRNA to a library of DNA sequences taken from the dendrites of neurons by James Eberwine of the University of Pennsylvania Medical Center, they found that it came from a single gene on chromosome X — the human version of which, when mutated, leads to fragile - X syndrome.

They found that when the gene was on the leading strand, the polymerase gaffed the copying up to 6 times more often than when the gene was on the lagging strand.

In one experiment with human cells, a guide RNA should have led the Cas9 enzyme only to a gene on chromosome 2 (yellow bar), but it also directed the enzyme to many off - target sites (red) on several other chromosomes.

In the steps of sperm - egg fusion, IZUMO1 on the spermatozoon and the IZUMO1 counter-receptor on the egg, JUNO, play crucial roles in the very first step, the formation of an intercellular bridge, and deletion of either gene leads to the failure of gamete membrane fusion.

«Solutions to understanding the connections between genes, neural circuits and behavior are now emerging from a unique union of genetics and neuroscience,» says Julie Korenberg, a University of Utah professor and an adjunct professor at the Salk Institute, who led the genetics aspects on the new study.

So, too, is the US military, according to Renee Wegrzyn, the DARPA programme officer leading its «Safe Genes» initiative, which supports research on restraining gene drives.

Two years ago the pharmaceutical giant GlaxoSmithKline purchased Sirtris for $ 720 million, and by August of last year The New York Times was speculating that compounds capable of activating sirtuin genes were now the leading candidates for what the newspaper called «the ultimate free lunch... a drug that tricks the body into thinking it is on [a calorie - restricted] diet.»

Right: By altering both chromosomes, gene drives ensure both copies of the altered gene are inherited, leading to a 100 percent chance of passing it on.

For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.

Left: One copy of the altered gene is inherited, leading to a 50 percent chance of passing it on per generation.

Ultimately, this week's discourse will lead to a consensus statement providing some guidance on how to approach using this and older gene editing technologies such as zinc finger nucleases and enzymes called transcription activator - like effector nucleases, or TALENs.

One research group [led by a former student] made mice with adult brain cells and forced them with a viral gene to turn on cell - division machinery.

In 2011, Science's editors will be watching a smaller detector at the Large Hadron Collider called LHCb, which will study B mesons in great detail; new techniques that should lead to the discovery of many more genes contributing to adaptation; an ignited fusion burn at the National Ignition Facility; broadly neutralizing antibodies, which are capable of disabling a wide range of viral variants; the first plug - in hybrid electric cars whose batteries are charged from a wall socket go on the market; and the results of the first phase III trial of a malaria vaccine.

However, the long - term effects of the daily bathing on the prevalence of the qacA / B genes that lead to resistance to CHG in MRSA isolates is largely unknown.

In this study, a team led by Panos N. Papapanou, DDS, PhD, professor and chair of oral, diagnostic and rehabilitation sciences at the College of Dental Medicine at CUMC, «reverse - engineered» the gene expression data to build a map of the genetic interactions that lead to periodontitis and identify individual genes that appear to have the most influence on the disease.

The research team led by Rui Martinho, from the Center for Biomedical Research at University of Algarve and from Instituto Gulbenkian de Ciencia, and Prashanth Rangan, from University at Albany, discovered that the timing of turning the genes back on is programmed directly into the chromosomes of the ovule.

The brain - size - altering effect of the gene is what led the researchers to study the impact on IQ.

A study led by researchers at Boston University School of Medicine (BUSM) provides novel insight into the impact that genes may have on Huntington's disease (HD).

23andMe, the test - your - own - genes company, has come under fire on moral grounds today for patenting a DNA prediction service that critics say could lead to «designer babies.»

Meanwhile, a second, smaller team led by Richard Fishel at the University of Vermont and Richard Kolodner at the Dana - Farber Cancer Institute in Boston was closing in on the same gene, using a more traditional strategy.

In one experiment this year, a team led by another CRISPR pioneer, Feng Zhang of the Broad Institute in Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma drug.

Wheat breeder Jorge Dubcovsky of the University of California, Davis, led an international team that discovered the gene — dubbed gpc - B1 for its effect on grain protein content — in a wild emmer wheat that has grown naturally in the Middle East for millennia.

«Previous techniques that have been used to investigate DNA control sequences usually rely on sorting cells one by one and measuring gene activity in each of them,» says Dr Eva Yus, lead author of the paper.

The international team, led by Professor Jacob George and Doctor Mohammed Eslam at the Westmead Institute, had previously identified that the common genetic variations associated with liver fibrosis were located on chromosome 19 between the IFNL3 and IFNL4 genes.

Unlike genetic mutations that affect DNA and the genome, epigenetic markers turn genes on and off to regulate cell processes, which if altered may lead to disease, he explains.

The body relies on cells to process and store energy, and changes in genes that regulate these functions can cause an imbalance that leads to excessive energy storage and weight gain.

A research group led by the American Museum of Natural History and global wild cat conservation organization Panthera has published the largest gene - based survey of its kind on wild jaguar populations in Mesoamerica.

Lead author Johan den Boon, associate scientist with the Morgridge Institute for Research at the University of Wisconsin - Madison, says the research team used gene expression profiling on 128 specimens from the Study to Understand Cervical Cancer Early Endpoints and Determinants, or SUCCEED.

Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus - like eremophytes instead of normal plants from the drought).

In separate studies reported in today's issue of Nature, a team led by geneticist Juan Carlos Ispisúa Belmonte at the Salk Institute in La Jolla, California, and another led by geneticist Cliff Tabin at Harvard Medical School found a very similar gene in chicks, named Radical fringe (R - fng), that is active on one side of a budding chick wing.

They also demonstrated significant advantages of editing gene regulatory sequences in their native location to uncover new functionalities that could lead to a better understanding of how control switches work to turn genes on and off in the body.

«First, there is no single road map to eusociality — the complex, cooperative social system in which animals behave more like superorganisms than individuals fending for themselves,» said Gene Robinson, a lead on the study who is a professor of entomology and director of the Carl R. Woese Institute for Genomic Biology at the University of Illinois.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

He writes: «If evolutionary psychology is on track... we believe the things — about morality, personal worth, even objective truth — that lead to behaviours that get our genes into the next generation.»

«Using next - generation gene sequencing on a small group of patients, we found that mutations in a sixth gene — ATF6 — can independently lead to the disease.»

The teams» three papers, each on Nordic dogs (Swedish Vallhund and Norwegian Elkhound) and each addressing blinding ocular diseases affecting both dogs and people, identified genes causing retinal disease and glaucoma, which may lead to gene therapies for dogs and humans.

Plus, the sustained antibiotic onslaught supposedly ensures that any hardier, partially drug - resistant bacteria also succumb, and thus don't pass on «stepping - stone» genes leading to full - blown resistance.

But this is the first time, to my knowledge, that the direct link is established from a novel gene to a novel structure to the invasion of a completely new ecological opportunity,» said Abderrahman Khila, an evolutionary and developmental genomicist at the Institute of Functional Genomics of Lyon, who led the study on the delicate insects called water striders.