Sentences with phrase «leads to cell death in»

The faulty gene leads to cell death in neurons in the brain resulting in gradual physical, mental and emotional changes, and ultimately death.

The inhibition of Rac1 also led to cell death in mouse lungs cultured in the lab.

Also, research in other animal models, such as rodents, has shown anesthesia exposure early in life can lead to cell death in the brain and cognitive impairments.

Not exact matches

In wet AMD, fluid leakage damages the RPE, leading to the death of light - sensitive cells and loss of vision.

«Imagine if we could create circuits that detect defects in cancer cells and then turn on pathways that lead to the death of those cells,» he says.

The disease is caused by a genetic mutation that leads to abnormal clumps of protein in the brain, eventually resulting in the atrophy and death of nerve cells.

Cultures representing two other hereditary liver diseases, alpha 1 — antitrypsin deficiency (a protein - folding disorder that leads to cell death and liver failure) and glycogen storage disease, type 1a (in which a liver enzyme deficiency impairs the body's glucose metabolism), also displayed disorder - specific abnormalities.

Roughly 2 % of people over age 35 have chronic glaucoma, in which fluid builds up inside the eyeball, leading to increased pressure and eventual death of cells in the optic nerve.

In patients with ALL, this leads to a sharp fall in serum levels of asparagine, hindering protein synthesis in malignant cells and inducing apoptosis, or programmed cell death.&raquIn patients with ALL, this leads to a sharp fall in serum levels of asparagine, hindering protein synthesis in malignant cells and inducing apoptosis, or programmed cell death.&raquin serum levels of asparagine, hindering protein synthesis in malignant cells and inducing apoptosis, or programmed cell death.&raquin malignant cells and inducing apoptosis, or programmed cell death.»

The new chimera interferes with HER2 and HER3 signaling and ultimately leads to cancer cell death, as shown in the group's recent publication in Molecular Therapy: Nucleic Acids.

«After circulatory arrest, spreading depolarization marks the loss of stored electrochemical energy in brain cells and the onset of toxic processes that eventually lead to death.

Even a change in temperature of + / - 5 ° C subjects the cell to a heat shock or cold shock, which can lead to cell death after a few hours.

These defects, in turn, affect the cell's ability to generate energy and can potentially lead to cell death and are associated with aging and various neurological diseases.

Still, by identifying the human hairless gene as an important master switch in regulating cell death in a hair follicle — a discovery that could lead to gene therapies for unwanted hair growth — Christiano emerged as a new star in the field, and a glamorous one.

Then, in the presence of TB drugs, that increased respiration will lead to rapid death of the cells.

Moreover, her studies are the first to indicate that therapies targeted at controlling the properties of smooth muscle cells within lesions may be highly effective in treating a disease that is the leading cause of death worldwide.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

The Duke team, lead by Timothy Haystead, Ph.D., a professor in the Department of Pharmacology and Cancer Biology, and Emily Derbyshire, Ph.D., assistant professor in the Department of Chemistry, conducted cell - based experiments to learn how the Takinib molecule influences a series of events to suppress cell death.

The prolonged presence of asbestos fibers lodged in the organ lining initiates a vicious cycle of chronic cell death and chronic inflammation that, over a period of many years, can lead to mesothelioma.

One reason group A Streptococcus and other invasive pathogens are so dangerous is they release pore - forming toxins that can poke holes in the membranes of cells within a person's body, leading to cellular dysfunction or cell death.

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.

They found that mice that had beta cells in which autophagy didn't work properly showed elevated levels of toxic IAPP, which led to the death of the beta cells.

Mitochondrial diseases affect the batteries of the cell and can lead to muscular weakness, blindness, fatal heart failure, learning disability, liver failure, diabetes and can lead to death in early infancy.

«This is important because the death of photoreceptor cells is known to cause retinal degenerative diseases in humans that lead to blindness.

Yet, this increases the probability that the other stem cells in the root stem cell niche will die due to the cold, leading to the plant's death.

«Our results solve the controversy about the possible side effects of APC / C inhibitors,» says Malumbres, adding that: «we have shown in vivo that their elimination leads to the death of rapidly dividing cells.»

In healthy cells constant growth can overwhelm cellular factories like the ER, leading to cell stress and death, but cancer cells manage to keep their factories running at high capacity to fuel non-stop growth.

The pathological hallmark of this disease is the accumulation of alpha - synuclein, which in turn leads to cell death and consequently to problems in neurotransmission.

This leads to the death of some islet cells, in turn decreasing the secretion of insulin and causing type 2 diabetes.

While doctors, nutritionists and researchers have known for a long time that saturated fats contribute to some of the leading causes of death in the United States, they haven't been able to determine how or why excess saturated fats, such as those released from lard, are toxic to cells and cause a wide variety of lipid - related diseases, while unsaturated fats, such as those from fish and olive oil, can be protective.

Research led by scientists at the Gladstone Institutes has identified the precise chain of molecular events in the human body that drives the death of most of the immune system's CD4 T cells as an HIV infection leads to AIDS.

In 2015, Rothstein's team found out how a mutation in a gene — implicated in 40 percent of inherited ALS cases and 25 percent of inherited frontotemporal dementia cases — gums up transport in and out of the nucleus in neurons, ultimately shutting the cell down and leading to its deatIn 2015, Rothstein's team found out how a mutation in a gene — implicated in 40 percent of inherited ALS cases and 25 percent of inherited frontotemporal dementia cases — gums up transport in and out of the nucleus in neurons, ultimately shutting the cell down and leading to its deatin a gene — implicated in 40 percent of inherited ALS cases and 25 percent of inherited frontotemporal dementia cases — gums up transport in and out of the nucleus in neurons, ultimately shutting the cell down and leading to its deatin 40 percent of inherited ALS cases and 25 percent of inherited frontotemporal dementia cases — gums up transport in and out of the nucleus in neurons, ultimately shutting the cell down and leading to its deatin and out of the nucleus in neurons, ultimately shutting the cell down and leading to its deatin neurons, ultimately shutting the cell down and leading to its death.

This gene is also involved in programmed cell death, leading to an increased permeability of the mitochondrial membrane.

Many diseases that lead to blindness, such as glaucoma and macular degeneration, are caused by the death of certain cells in the human retina that lack the ability to regenerate.

Recently, many scientists came to suspect that a protein called NF - κB, a master regulator of infection and inflammation, was at work; in 1996, several groups had found that it also inhibited cell death, which can lead to tumor formation.To find out whether suspicions about NF - κB were well - founded, molecular biologist Michael Karin of the University of California, San Diego, and his colleagues turned to a mouse model of colitis.

Claire Bale, Research Communications Manager at Parkinson's UK, said: «We've known for decades that problems with mitochondria — the batteries of the cell — play a key role in the death of nerve cells in Parkinson's, but the research in this area hasn't yet led to new treatments.

Because digoxin and other cardiac glycosides have been shown to induce cancer cell death, the researchers concluded that infection by Zika triggered synthesis of the molecule in glioblastoma cells and that this phenomenon is probably one of the factors that lead to neuronal cell death.

The discovery, which is described online in the journal Cell, may lead to new ways to trigger cell death in some types of cancer ceCell, may lead to new ways to trigger cell death in some types of cancer cecell death in some types of cancer cells.

If the compound identified in this study successfully reduces tissue death and improves recovery in further experiments, it could lead to new approaches for preserving brain cells after an ischemic stroke,» said Francesca Bosetti, Ph.D., Pharm.D., program director at the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

These results collectively suggest that neural stem cells need MSI1 to generate enough neurons for normal brain size, but the presence of MSI1 also increases the vulnerability of these cells to Zika infection, leading to the death of the population which ultimately results in microcephaly.

Reporting in Science, a team led by researchers from the Broad Institute of MIT and Harvard, Brigham and Women's Hospital, and Harvard Medical School describes a new approach to prevent death in these essential kidney cells.

Minocycline, a synthetic tetracycline - based antibiotic, has shown only limited success as an anti-cancer agent because it promotes the expression of pro-survival Bcl - 2 proteins and, subsequently, can lead to inhibition of caspase - 3 and caspase - 9 activation downstream in the cell death pathway.

Professor Sherif El - Khamisy, who led the research, said: «If we can find a way to hijack the cancer's fix and repair toolkit and make it less efficient, then we can tip the scale in favour of cancer cell death instead of survival and prevent resistance to chemotherapy.

Tilly's team demonstrated a remarkably tight and specific chain of events leading to egg cell death, says Jerrold Heindel, a toxicologist at the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina.

Soon the rabbits began producing proteins that triggered angiogenesis in the animals» legs and halted the process of cell death that leads to gangrene.

«We discovered that metastasizing melanoma cells experience very high levels of oxidative stress, which leads to the death of most metastasizing cells,» said Dr. Sean Morrison, CRI Director and Mary McDermott Cook Chair in Pediatric Genetics at UT Southwestern Medical Center.

This has the potential to initiate a positive feedback loop in which ROS drive further uroporphyrinogen I oxidation, leading to oxidative stress and pigment cell death.

Saxitoxin is a potent neurotoxin that blocks the flow of sodium in the nerve cells leading to numbness, paralysis and death.

The team led by Rory Fisher, Ph.D., professor of pharmacology in the UI Carver College of Medicine, has identified a protein called RGS6 (regulator of G protein signaling 6) that acts through two separate mechanisms to control alcohol - seeking behavior and alcohol - induced cell death in heart, liver, and other organs.

Mitochondria produce energy for the cell and if they are damaged or not working correctly, it can result in the damage and eventual death of RGCs leading to blindness.