But the babies of adiponectin - treated mice were about the same weight as those born to
lean control mice, the researchers report online today in the Proceedings of the National Academy of Sciences.
Not exact matches
«Importantly, we found that blocking the actions of the endocannabinoids with pharmacological inhibitors of cannabinoid receptors in the periphery completely normalized food intake and meal patterns in western diet - induced obese
mice to levels found in
control lean mice fed standard chow.»
Associate Professor Amanda Sainsbury - Salis expressed surprise at the impact of the Y6 gene deletion on
mice, commenting «I find it amazing that one gene, which is expressed in the small part of the brain that
controls the body clock, has such a profound impact on how much fat is stored on the body, and how much
lean tissue is maintained.»
Based on the observation that obese
mice, rats, and humans all had elevated serum concentrations of a protein called GDF15 compared to
lean controls, Yumei Xiong and colleagues set out to develop therapies derived from the molecule.
This is interesting, given that muscle /
lean muscle mass ratios of non-skeletal muscle organs from IL - 15Rα — KO
mice, such as the heart, spleen, and kidneys, were not significantly different from those of B6129
controls.
(B)
Lean muscle mass, assessed using NMR, was 18 % less in IL - 15Rα — KO
mice (n = 8) compared with B6129
control mice (n = 8).
However, when these organ weights were normalized to
lean muscle mass, the organ /
lean muscle mass ratios were not significantly different from B6129
control mice (Figure 4, F — H).
This difference may be explained by the reduced levels of normal CST in obese
mice compared to the
lean control animals.
Results showing C. minuta has an effect of
controlling fat gain in the
mouse match data that reveal
lean people have a greater abundance of C. minuta in their gut than obese people.
Actually, the leucine - deprived
mice showed no difference in
lean mass, from either the
control mice or those that were restricted to the same number of (reduced) calories consumed by the leucine - deprived
mice.
Pair - fed
mice lost only 5 percent of bodyweight, and their
lean mass did not change appreciably; leucine deprived
mice lost 15 percent of body - weight, and their
lean mass was the same as the
control mice, and unchanged.There were no strength or endurance challenges, but when one considers that the
mice lost 50 percent of abdominal fat, 15 percent of bodyweight, and had no loss of
lean mass, that is incredible.