Sentences with phrase «lean mice»

Scientists reached this conclusion by transferring microbes from bypass - treated obese mice to a group of lean mice raised in sterile conditions that left them with no intestinal bacteria at all.

What's more, intestinal bacteria from obese mice increased fat gain more than bacteria from lean mice (1).

Other studies have revealed that lean mice didn't gain as much weight when a high fat diet is supplemented with green tea.

After exercising for six weeks, both obese and lean mice showed a significant reduction in the overall size of fat cells and the overall amount fat in the marrow.

A team of researchers transplanted gut bacteria from obese mice into lean mice.

DiPatrizio and Argueta were surprised to find that inhibiting peripheral endocannabinoid signaling with inhibitors like AM6545 completely normalized intake to that found in lean mice maintained on a standard chow.

They lost 60 percent of their body fat before they died of starvation, but still had five times as much body fat as lean mice -LRB-!!!!!!) * that were allowed to eat as much as they desired.

«Importantly, we found that blocking the actions of the endocannabinoids with pharmacological inhibitors of cannabinoid receptors in the periphery completely normalized food intake and meal patterns in western diet - induced obese mice to levels found in control lean mice fed standard chow.»

The latter then observed a significant increase in obesity, compared to mice with microbiota transplants from lean mice who were fed with a lean low - fat diet, where these differences weren't nearly as high.

By studying lean mice that were engineered to have the same defect in the D2 receptor, they found that those mice did not gain weight more readily on a high - fat diet, despite their lack of inactivity, suggesting that weight gain was compounded once the mice start moving less.

«Importantly, regulation by p75NTR enhanced insulin's effectiveness in normal lean mice on a normal diet,» said Bernat Baeza - Raja, PhD, postdoctoral fellow and lead author of the study.

These mice lived just as long as semi-starved lean mice, even though they had at least four times the body fat of normal mice.

Protective antibodies from lean mice also failed to protect obese mice from flu infections.

«This is the first study to show that current strategies to bolster the effectiveness of flu vaccines protected lean mice from serious illness but fell short of protecting obese mice from infections,» said corresponding author Stacey Schultz - Cherry, Ph.D., a member of the St. Jude Department of Infectious Diseases.

A single dose of IRAB - A given to lean mice rapidly reduced fed blood glucose for approximately 2 weeks, with concomitant reduced insulin levels suggesting improved insulin sensitivity.

When these mice were co-housed, the newly obese mice (obese microbiota) didn't gain any new weight due to invaders from the microbiota of the newly lean mice (lean microbiota).

Indeed, when these fat mice are starved, they do not become lean mice... they become emaciated versions of fat mice.

Astonishingly, when germ - free mice are colonized with the gut microbiota from genetically obese mice (ob / ob), the otherwise lean mice dramatically increase body weight.

Even more interesting, when you transplant the bacteria from obese mice into lean mice, the formerly lean rodents gain weight.

Administering CST had no effect on insulin or glucose tolerance in control lean mice, showing that the effect of CST is restricted to obese animals.

In addition, lean mice who received vaccines with adjuvants were protected from severe flu infections.

Lambert, who worked with Kimberly Grove and Sudathip Sae - tan, both graduate students in food science, and Mary Kennett, professor of veterinary and biomedical sciences, said that other experiments have shown that lean mice did not gain as much weight when green tea is added to a high fat diet.

And if starved sufficiently, these animals can be reduced to the same weight as lean mice, but they'll still be fatter.

To explore that question, a team led by Cornell University biomedical engineer Claudia Fischbach first showed that female mice that were obese, because of genetics or a high - fat diet, had more fibrous mammary fat pads with straighter collagen fibers than those seen in lean mice (see image).

Other studies have demonstrated that microbes implanted from lean mice into overweight mice caused the mice to lose weight.

«How obesity dulls the sense of taste: Obese mice had about 25 percent fewer taste buds than lean mice in study.»

In another animal microbiome experiment, Jeffrey Gordon, a biologist at Washington University in St. Louis, took a suite of microbes from the guts of both obese and lean mice and transplanted them into the guts of microbe - free mice.

«The nondigestible compounds in the Granny Smith apples actually changed the proportions of fecal bacteria from obese mice to be similar to that of lean mice,» Noratto said.

Moreover, obese - phenotype mice were invaded by members of the Bacteroidales from the lean mice, but, happily, the lean animals resisted invasion by the obese microbiota.

New research has discovered that diabetes — or insulin resistance — in aged, lean mice has a different cellular cause than the diabetes that results from weight gain (type 2).

The heavier mice had higher levels of proteins involved in detoxification and stress responses; the lean mice expressed more genes involved in breaking down dietary fiber.

While a common prebiotic supplement did not help the mice shed weight, it completely reversed the other symptoms, making the guts and joints of obese mice indistinguishable from lean mice.

Compared to lean mice, osteoarthritis progressed much more quickly in the obese mice, with nearly all of their cartilage disappearing within 12 weeks of the tear.

The scientists found that obese mice had more harmful bacteria in their guts compared to lean mice, which caused inflammation throughout their bodies, leading to very rapid joint deterioration.

The knee cartilage of obese mice who ate the oligofructose supplement was indistinguishable from that of the lean mice.

While IRAB - A produced a decrease in blood glucose in lean mice, the data in DIO mice indicated an exacerbation of insulin resistance; these data were unexpected and suggested the interplay of complex unknown pharmacology.

Although hyperphagia contributes to the obesity, homozygotes gain excess weight and deposit excess fat even when restricted to a diet sufficient for normal weight maintenance in lean mice.

In the overweight mice, there was a significant weight lose after eight weeks, but the case was not the same with the lean mice.

One group consisted of lean mice without having been tampered, another group of lean mice had their myostatin blocked, the third group consisted of obese mice that had a normal myostatin level and the final was made out of obese mice with blocked myostatin.

Transplanting gut flora from obese mice into lean mice turned the formerly lean mice fatter... Compelling evidence that gut flora has an important connection to body fat levels.

The lean mice enjoyed a 60 % increase in body fat and a rapid, 14 - day descent into insulin resistance following the gut flora alteration.

Their procedure involved infecting mice without microbiota with either microbiota of obese or lean mice.

This study showed that the microbiota of lean mice (one group of mice was lean and the other was obese) was more invasive than those of obese mice.