Finally, we assessed how the oscillatory spectral profiles and theta - gamma relationship observed at rest in
left auditory cortex related to effects in the distributed language network during the movie.
As both the theta - and gamma - informed MRI models showed significant effects in
left auditory cortex during movie viewing, we assessed gamma and theta oscillations engagement during movie viewing (rest vs. movie) in each group in this region.
Using this approach, we observed that
left auditory cortex was more weakly coupled to Broca's area (BA 44/45), BA39 and 40, and the premotor cortex in ASD than in controls.
In autism, neural activity was reduced in the left supplementary motor area and
left auditory cortex (whole brain interaction p < 0.02, uncorrected; Heschl's gyrus, p = 0.02 FWE corrected; 54, -19, 7 MNI coordinates), and enhanced in bilateral visual cortex (whole brain p < 0.01 uncorrected, 3, - 91, -8 MNI coordinates).
We observed a negative relationship in controls in
left auditory cortex [r (13) = -0.58, p = 0.037, Figure 2C, left], confirming a functional dependency between theta and gamma under physiological conditions, compatible with gamma activity being down - regulated by theta activity.
Not exact matches
In particular, in the BOLD signal changes in response to the altered music (compared to the original music) were smaller in the right primary and secondary
auditory cortex (Fig. 2 and Fig. 4), but larger in
left - hemispheric superior temporal and inferior - frontal
cortices (Fig. 2B).
BOLD responses to the movie occurred in visual and
auditory brain areas in both groups, yet were less pronounced in the ASD group in
left superior parietal and superior temporal
cortices (
auditory cortex, Figure 1A).