Sentences with phrase «leptin gene in mice»

Also, knocking out the leptin gene in mice showed that this hormone regulated appetite.

Not exact matches

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

Scientists had been searching in vain for such a gene since 1994 when Rockefeller University scientist Jeffery Friedman found that lab mice with a specific genetic mutation fail to produce leptin and as a result have uncontrollable appetites, and become huge.

One team has found in two children mutations in the gene for the metabolic hormone leptin, which in mice tells the body it's satiated; defects in this gene had not previously been found in obese people.

Mice without the leptin gene, called ob / ob, overeat, weigh in at three to four times normal, and develop symptoms similar to the obesity - related diabetes seen in humans.

In a remote Turkish village, researchers have located a family with a mutation in the leptin gene similar to the one found in lab mice, and — just like the mice — adults with two copies of the mutation are grossly overweight and don't ever go through pubertIn a remote Turkish village, researchers have located a family with a mutation in the leptin gene similar to the one found in lab mice, and — just like the mice — adults with two copies of the mutation are grossly overweight and don't ever go through pubertin the leptin gene similar to the one found in lab mice, and — just like the mice — adults with two copies of the mutation are grossly overweight and don't ever go through pubertin lab mice, and — just like the mice — adults with two copies of the mutation are grossly overweight and don't ever go through puberty.

The revolution in obesity research began less than five years ago with the landmark discovery of a gene for leptin, the weight - regulating hormone found in both mice and people.

In 1994 scientists discovered that mice missing both copies of their leptin gene develop excessive body fat, extreme hunger, and sterility.

This gene therapy resulted in high - fat diet mice having a reduced body weight, building up less fat, expending more energy, and showing evidence of improved leptin - signalling.

Much of our knowledge of leptin comes from the study of two brands of lab mouse: the ob / ob mouse, deficient in genes responsible for leptin production; and the db / db mouse, deficient in the leptin receptor gene.