This means that
the less myostatin you have, the more muscle you can build.
According to these studies,
less myostatin also means about 15 % longer life.
Not exact matches
If you've read up on your biology, you will know that
myostatin is a protein that inhibits muscle growth — the more you have of it, the
less your muscles will grow and vice versa.
After about 48 and 72 hours, even though the satellite cells and the
myostatin levels got back to their baseline values in the group that ate more protein, the levels remained lower for a longer period in the group that ate
less protein.
Finally, consuming calories at
less than maintenance levels — which is what most people attempt to do when dieting — also increases the concentration of
myostatin in muscles, leading to muscle wasting [24].
It requires a lot more energy and does a lot more damage doing say, 10 × 10 (or your 15 × 5), than it does doing one set of 25 - 50 or 50 - 100 reps.. In the end, you get
less hypertrophy with high volume heavy lifting, because a) you still have all that
myostatin buildup from heavy lifting suppressing hypertrophy, b) you don't sufficiently fatigue medium and fast twitch fibers, c) you don't get the increased IGF - 1 production and increased protein synthesis that you would get from high reps, and d) because the energy requirements of repairing the damage caused by heavy lifting are too high.