In another experiment, mice lacking the cells that produce serotonin scratched
less than normal mice when exposed to a skin irritant.
Chen and colleagues report online today in Science that mice without GRPR neurons scratched significantly
less than normal mice did — about 80 % less in each case.
The scientists also noticed that Clock mice slept about one to two hours
less than normal mice, and when they weren't sleeping, they were eating.
Not exact matches
Laboratory
mice that have received rapamycin have reduced the age - dependent decline in spontaneous activity, demonstrated more fitness, improved cognition and cardiovascular health, had
less cancer and lived substantially longer
than mice fed a
normal diet.
The NK1R - deficient
mice consumed far
less alcohol — especially later in the trial when alcohol concentration was higher —
than the
normal mice did.
They were also more sensitive to alcohol's effects
than the
normal mice were; studies have shown that the more sensitive a person is to alcohol, the
less likely he or she is to abuse it.
When the researchers then induced stroke in
mice either with or without the PARP gene, they found that the resulting tissue damage in the
mice without the enzyme was 80 %
less than in
normal mice.
In contrast, M49, a
less virulent strain of strep, caused larger skin lesions in
mice lacking cathelicidin
than in
normal, cathelicidin - producing
mice.
As a result, they have
less than half of the fat tissue found in
normal, aged
mice.
That indicates that they are
less anxious
than normal mice, the researchers report online today in the Proceedings of the National Academy of Sciences.
Obese
mice gained
less weight after exercise or WBV
than obese
mice in the sedentary group, although they remained heavier
than normal mice.
Mice with a disrupted biological clock slept less, ate more, and gained more body fat than normal mice, indicating that, when it comes to understanding the molecular basis of obesity, timing may be
Mice with a disrupted biological clock slept
less, ate more, and gained more body fat
than normal mice, indicating that, when it comes to understanding the molecular basis of obesity, timing may be
mice, indicating that, when it comes to understanding the molecular basis of obesity, timing may be key.
Their study showed that
mice without the Y6 gene were smaller, and had
less lean tissue,
than normal mice.
To investigate, Akhtar deleted the gene for Rac1 in female
mice; their first litter of pups survived, but they were smaller
than normal — probably because the milk they received contained
less fat and protein
than normal.
Transgenic males weighed 10 percent more
than normal males, but Bartfai says that the heft indicates that the transgenic
mice required
less energy to maintain their core temperature.
KLF15 - deficient
mice produced 40 to 50 percent
less bile acid
than normal mice, making them
less capable of absorbing the lipids and the nutrients they contained.
The scientists found that transgenic
mice in which phospholipase Cγ1 was unlinked from the TrkB receptor were
less susceptible to seizures
than normal mice.
However, by the time these
mice reached adulthood, around 8 months old, the level of photoreceptor cells in these knockout
mice was
less than half the
normal level.
As seen through a microscope, the leg bone of a
normal mouse (left) makes considerably
less new bone
than a
mouse that produces high levels of a signaling protein, WNT7B, that stimulates new bone growth (shown in pink on the right).
It should be noted, however, that while a study on senescent cell ablation in genetically
normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show
less effect
than could be anticipated in a large mammal model, since even normally - aging
mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to
mice.
Takeda et al. engineered
mice that were either unable to produce a particular LPA receptor on their T - cells, or that produced
less LPA
than normal.
mouse studies, macrophages taken from obese
mice were
less receptive to insulin
than normal (in other words insulin resistant to a degree).
The control
mice are
normal mice, eating as much as they will; the pair - fed
mice are
normal mice eating a
normal diet, but only as much as the leucine - deprived
mice chose to eat; the leucine deprived
mice ate as much as they wanted, but they chose to eat 15 percent
less than the control
mice, (thus, the pair - fed also ate 15 percent
less than control, but it was a diet that contained a
normal amount of leucine).