Sentences with phrase «letter in a single gene»

anemia and others result from a misplaced base letter in a single gene.

Not exact matches

But, as journalist Steve Connor reports, the reference to editing was intentional: «Scientists have used the genome - editing technology to cure adult laboratory mice of an inherited liver disease by correcting a single «letter» of the genetic alphabet which had been mutated in a vital gene involved in liver metabolism.»

After gene - typing about 3,000 people, Sturm found that how OCA2 is expressed — and how much pigment a person has — is strongly linked to three single nucleotide polymorphisms (SNPs), or single letter variations, in a DNA sequence near the OCA2 gene.

The team found that a single polymorphism (a difference in one «letter» of the sequence) in the BDNF gene accounted for significant differences in intelligence among those with similar injuries and comparable intelligence before being injured.

An alteration in the neuregulin - 1 gene — a single change in one letter of the DNA code for the protein — has been found in families with schizophrenia and linked to late - onset Alzheimer's disease with psychosis.

Researchers say that each progeria case arises randomly due to a single letter change in one gene of the child's DNA.

Further analysis revealed that a single - letter change in the gene accounted for 46 per cent of the population's hair colour variation, with the blonde allele being recessive to the dark hair allele.

PENCIL IT IN Scientists have used two new versions of CRISPR gene editors, which rewrite DNA like pencils instead of cutting like scissors, to change single - letter typos that cause some blood disorders.

Although mutations come in many varieties, one type, called nonsense mutations, involve the seemingly innocuous change of a single letter in the coded message — a change that causes the gene's message to prematurely read «stop.»

Carrying two copies of a single - letter change in the DNA of chromosome 16 led to a 35 per cent increase in activity of the gene GSPT1 ¬ in men with testicular cancer, compared with those without.

The researchers discovered a single letter variant located in TP53, a gene known to play a central role in tumor biology and for accumulating so called somatic mutations, during the development of cancer in patients.

Using gene sequencing, the researchers learned that every member of the family with congenital heart disease had the same mutation in GATA4 — a change in a single letter in the gene.

To avoid these problems, the team used sequence data to create a list of single DNA letter changes, known as SNPs, which can be reliably identified in the gene - rich areas of the genome.

However, although CRISPR / Cas is currently good at changing single letters in DNA, it can not yet specifically target the expanded gene and reduce the number of CAG repeats.

In the first paper, utilizing genomic analysis of nearly 8,500 Icelandic and Dutch participants, the deCODE team identified a novel, tightly - linked pair of single - letter variants (SNPs) near the ASIP (agouti signaling protein) gene on chromosome 20 that greatly increase the likelihood of an individual being prone to freckles and sunburn.