Sentences with phrase «leukemia proteins»

Tests of blood, saliva, or tears can look for specific leukemia proteins.

Not exact matches

In turn, these modifications are caused by two specific proteins of the so - called chromatin regulator group, on which leukemia cells are dependent.

«Protein isolated from baker's yeast shows potential against leukemia cells: Researchers performed in vitro trials to test the effect of L - asparaginase on acute lymphoblastic leukemia cells and published the results in Scientific Reports.»

A protein domain once considered of little importance may be key to helping patients who are fighting acute myeloid leukemia (AML) avoid a relapse.

«New clue to halting leukemia relapse found: Molecule created that attacks chemo - inhibiting protein.»

This clinical trial sponsored by Juno Therapeutics is testing JCAR017, which targets the CD19 protein expressed on most B - cell leukemias and lymphomas.

However, in some patients, the leukemia recurred without the CD19 target and expressed a protein that the CAR T cells were unable to recognize — CD22.

In PLAT - 02, the CAR T cells are reprogrammed to recognize and target the CD19 protein that is expressed by most precursor B acute lymphoblastic leukemia cells.

The team started by analyzing bone marrow samples from children with B - ALL and cataloging every protein present in the leukemia cells.

«Further research is needed to characterize how we can potentially remove or block this protein to stop the proliferation of leukemia cells.»

They will examine the safety and feasibility of administering cancer - fighting chimeric antigen receptor (CAR) T cells that have been reprogrammed to target the CD22 protein expressed by some leukemia cells.

UCLA scientists have uncovered how a cellular protein contributes to an aggressive form of leukemia prevalent in young children.

With the PLAT - 04 trial, researchers will now be able to reprogram CAR T cells to detect and destroy leukemia cells that express the CD22 protein.

The researchers also found that removing the IGF2BP3 protein from leukemia cells led to decreases in leukemia - promoting messages, which in turn killed the leukemia cells.

They discovered that IGF2BP3 binds to and stabilizes hundreds of leukemia - promoting RNA messages and consequently increases how much protein is made, resulting in an environment that is conducive to leukemia cell growth.

The gene (E2A) that codes for proteins with the properties of immunoglobulin enhancer binding factors E12 / E47 was mapped to chromosome region 19p13.2 - p 13.3, a site associated with nonrandom translocations in acute lymphoblastic leukemias.

If so, says Grover Bagby, a hematologist who directs the Oregon Cancer Center at the Oregon Health Sciences University in Portland, further work to decipher the protein's exact function could shed light on how to treat a much larger population of patients with leukemia, certain other forms of cancer, and aplastic anemia.

The lack of the normal protein or a mutated version may play a role in how anemia patients acquire leukemia.

Although insufficient on its own to trigger leukemia, f - circM9 appears to work together with other cancer - promoting signals (such as the MLL - AF9 fusion protein) to cause disease.

Significantly, disabling both anti-apoptotic proteins, Bcl - 2 and Bcl - xL, in conjunction with Mcl - 1, caused profound cell death of leukemia cells in the test tube as well as in animal models of AML.

Rhesus monkey TRIM5α protects against HIV - 1, but the only modern virus that the human protein has any effect on is one that causes leukemia in mice — which happens to be closely related to PtERV1.

The findings are particularly noteworthy because drugs that act on the newly discovered target, a protein known as PIM1, are already in clinical trials for leukemia and multiple myeloma.

Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that p300, a protein that increases gene expression by attaching acetyl molecules to DNA, may stop myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML).

While p300 apparently plays a critical role in MDS progressing to leukemia, this function is highly contextual as the protein has no obvious effect on healthy stem cells.

To overcome this hurdle, researchers genetically engineered human T cells to produce a CAR protein that recognizes a glycopeptide found on various cancer cells but not normal cells, and then demonstrated its effectiveness in mice with leukemia and pancreatic cancer.

The engineered cells contain an antibody - like protein known as a chimeric antigen receptor (CAR), which is designed to bind to a protein called CD19 found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia.

The vaccine sets off an immune response using a piece of a protein, called PR1 peptide, found on the surface of leukemia cells.

Dr Xu showed that for BET inhibitors to successfully kill lymphoma and myeloid leukemia cells the presence of a protein called BIM, which brings on apoptosis, was critical.

The modified T cells contain a protein known as a chimeric antigen receptor (CAR), which is designed to target the CD19 protein found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia and lymphoma.

«Role of RNA binding protein in driving cancer, leukemia study reveals: Abnormally expressed in cancer cells, the protein was found to promote the proliferation of B cells in B - cell acute lymphoblastic leukemia.»

This allowed them to the see entire complement of proteins regulated by TRAF6 in leukemia cells.

In the case of IGF2BP3 and B - cell leukemia, the overall effect of the RNA binding protein is to promote the proliferation of B cells by shifting the expression of a large number of genes, Sanford said.

A study of gene expression in leukemia cells has identified an RNA binding protein that plays an important role in driving the development of cancer.

When investigators treated the leukemia cells with a JQ1 - and - phthalimide «conjugate» called dBET1, the BRD4 protein within the cells was degraded in less than an hour.

Focusing on two proteins known as transcription factors, the researchers showed that genetically removing the two transcription factors, Tcf1 and Lef1, in mice is sufficient to prevent leukemia stem cells from persisting.

When Ralph Arlinghaus, a molecular biologist at the University of Texas MD Anderson Cancer Center in Houston, learned that growth factor — starved healthy cells release a protein called 24p3 that causes them to die, he wondered if leukemia cells also use the molecule to kill off their competition.

ANAHEIM, CALIFORNIA — Chronic myeloid leukemia (CML) cells invade the bone marrow and spleen by destroying healthy cells with a toxic protein, according to a new study.

A class of therapeutic drugs known as protein kinase inhibitors has in the past decade become a powerful weapon in the fight against various life - threatening diseases, including certain types of leukemia, lung cancer, kidney cancer and squamous cell cancer of the head and neck.

By analogy to the gag / abl fusion protein of Abelson murine leukemia virus, the replacement of amino terminal c - abl sequences by bcr sequences in P210 may create a transforming protein involved in CML.

In cancer, a state marked by increased protein translation and biomass expansion, HSF1 is activated and binds to numerous genes throughout the genome, as seen in the heat map of HSF1 ChIP - Seq read density in M0 - 91acute myeloid leukemia cells (DMSO, far left).

The symbol ABL is derived from Abelson, the name of a leukemia virus which carries a similar protein.

A CAR is a protein composed of an antibody that can bind to a known target — in our model we picked the CD19 antigen found on B cell leukemias.

An exciting development in rational anticancer drug design is Gleevac, a drug that acts on a protein unique to the defective white blood cells in chronic myelogenous leukemia and on a related protein in a rare form of gastrointestinal cancer.

Activation of both protein kinase A (PKA) type I and PKA type II isozymes is required for retinoid - induced maturation of acute promyelocytic leukemia cells.

Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax.

«It may be that the normal TEL allele successfully suppresses the function of the aberrant TEL - AML1 protein resulting from the fusion, so full - blown leukemia doesn't occur,» said the lead author of the study, Joseph Wiemels, PhD, now a UCSF assistant research molecular epidemiologist.

Secretion of the human T cell leukemia virus type I transactivator protein tax.

The synthetic peptide PFWT disrupts AF4 — AF9 protein complexes and induces apoptosis in t (4; 11) leukemia cells.

In 2001 imatinib was approved for the treatment of chronic myeloid leukemia, a disease that is almost universally caused by a single genetic mutation, known as the Philadelphia chromosome, and its resulting mutant protein.

In fact, mutations in a human protein highly related to the yeast histone methyltransferase Set1, called MLL, are involved in leukemia.