Not exact matches
To determine the genetic basis for his exceptional response, researchers at the Dana - Farber Cancer Institute, Stanford University, Brigham and Women's Hospital and elsewhere performed targeted and whole - exome
sequencing on his
leukemic cells.
The short size of the locus was ideal for 454
sequencing, and because single - molecule reads are generated, the authors were able to identify haplotypes of somatic hypermutations carried by individual
leukemic cells.
«In our research project on pediatric leukemia we plan to use Gemcode to define the exact chromosomal breakpoints of large scale chromosomal rearrangements and repetitive
sequences that are typical for
leukemic cells, but are difficult to characterize in short
sequence reads,» said Professor Ann - Christine Syvänen, who leads the Molecular Medicine group.