Sentences with word «leukemogenesis»

Intriguingly, the initiating driver mutation of leukemogenesis occurred before the earliest branching of trees.

5) Saurabh K, Scherzer MT, Shah PP, Mims AS, Lockwood WW, Kraft AS, Beverly LJ (2014) The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.

The research findings have now been published in the journal Blood with the following title: «The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis».

AML1 - ETO and C - KIT mutation / overexpression in t (8; 21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.

The lab uses experimental models of disease to investigate how pathways that contribute to normal lymphopoiesis are hijacked during leukemogenesis, and invoke the protective response of tumor suppressors.

The described approach represents the first molecularly targeted treatment of NPM1mut leukemias by reversing a key mechanism of leukemogenesis and builds a basis for future clinical trials assessing these drugs in patients with NPM1mut leukemia.

, Kraft AS, Beverly LJ (2014) The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.

More than half of the missense mutations were predicted to be deleterious, suggesting an enrichment for driver mutations involved in leukemogenesis.

Anna Sedello (Buchholz, MPG)-- «Loss - of - functionscreen for proteins cooperating with Runx1 in hematopoiesis and leukemogenesis» (2009)

Notably, 51 % of the validated SVs had breakpoints in protein - coding genes, including several with roles in hematopoiesis or leukemogenesis.

Maciejewski, J.P. and Padgett, R.A. Defects in spliceosomal machinery: A new pathway of leukemogenesis.

The major objective of Drs. Danska and Guidos research program is to understand these disrupted molecular pathways and position this information within the cellular and developmental context of leukemogenesis.

The workshop will focus on topics such as; hematopoietic stem cell biology, leukemogenesis, cell signaling, transcription factors, epigenetic effects, and other topics related to myeloid biology.