However, understanding the importance of the T cell response could help researchers prevent the development of progressive
multifocal leukoencephalopathy in autoimmune patients.
It is a progressive
leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes.
Progressive
multifocal leukoencephalopathy (PML) is a rare disease of the brain's white matter caused by the John Cunningham polyomavirus (JCV), a usually harmless virus that infects up to 80 percent of healthy adults.
Genetic modification in zebrafish models is cheap and easy, so authors point out that future research on these animal models will contribute to understand the molecular relationship that exists between the proteins involved in the physiopathology of megalencephalic
leukoencephalopathy.
Oligodendrocytes and stem cell transplantation: their potential in the treatment of
leukoencephalopathies.
Infants with Alexander disease develop
a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation.
To answer this, the researchers developed a new mouse model of polyomavirus infection that shares many characteristics that are seen in progressive multifocal
leukoencephalopathy.
These findings raise the possibility that viral shell mutations may influence the T cell response to John Cunningham polyomavirus in humans, and play a role in the development of progressive multifocal
leukoencephalopathy, the researchers wrote in the Journal of Virology.
In a 2012 study, researchers reviewed the incidence of progressive multifocal
leukoencephalopathy (PML) in clients detected with autoimmune rheumatic conditions (ARD) such as RA, lupus, or Sjögren's syndrome.
In October 2008, the FDA forced Raptiva's manufacturer to add a black box warning to the drug package, after at least four fatal cases of progressive multifocal
leukoencephalopathy (PML) had been identified among patients who were treated with Raptiva.
Research shows the immunosuppressant belatacept — sold under the brand name Nulojix — causes post-transplant lymphoproliferative disorder and progressive multifocal
leukoencephalopathy.