Sentences with phrase «level driving these changes»

The next challenge for the team is to identify what might be some of the mechanisms at the molecular level driving these changes.

Not exact matches

The most profound changes may come from the development of a truly intelligent car — vehicles with increasing levels of knowledge about the driver and driving conditions, from the road itself to traffic patterns to even the weather.

Canaccord Genuity strategist Tony Dwyer, who called for a rough patch before the downturn began, says, «The two - month intermediate - term correction has been driven by correcting a historical level of optimism rather than a significant change in our positive fundamental thesis.»

Growth prospects in the company's original niche — rubber stamps — leveled off (some might say they nearly died), and technological changes prompted moves to computer - driven phototypesetting, desktop publishing, sign making, and everything else that could mark the spot for the manufacturer's 800 or so corporate and government - agency clients.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Level 3 means the car can handle what's called «dynamic driving tasks» like steering, braking, and changing lanes.

While the ideas are by no means earth shattering, they are fundamental to driving the kind of sea - level change needed at Uber:

One problem is that dangerous levels of climate change are exacerbated by positive feedback loops — changes that release more greenhouse gases from nature due to warming driven by humans.

By galvanizing the leadership of the women's business community, Roadmap 2020 will drive change on the national and grassroots level, and dramatically sharpen the nation's competitiveness.

The topics were informed by interviews with both industry and research, with some being primarily driven by advances and investment in science and technology while others require broader operational changes at the business and ecosystem level.

At mill level we can use our commercial leverage and drive change, through the mill, at the plantation level — the very base of our supply chain.»

It aims to link the image of Euskadi to the shared values of Basque society, such as a strong work ethic, commitment, drive to succeed, striving for change and equal opportunities for men and women, and to make these values our calling card at an international level.

When breastfeeding, your hormone levels change, and for many, sex drive tanks.

We are now beginning to understand some facets of human emotionality, decision - making, morality, trauma and the drive for political power down to the cellular level, by observing changes in neurochemistry, neural pathways, and neuro - anatomical transformations in the brain.

«However, it is concerning that despite rising levels of sexual bullying and sexual harassment by children and young people, the provision of PSHE and SRE has been under pressure as a result of Government - driven curriculum reforms, funding cuts and changes to accountability requirements.

The only factor that could change the start date in Suffolk is a bill proposed by Legislator Leslie Kennedy (R - Nesconset) that aims to close a loophole critics say would allow level 1 sex offenders to drive for ride - sharing services.

«The NASUWT predicted that the funding changes, driven by a desire by the Department for Education to mask the level and impact of cuts to school and local authority budgets, would result in those who needed the support to address their needs losing it.

The Town of Greece has started a petition drive in an effort to get changes to a plan that affects the level of water in Lake Ontario.

Instead, he proposed lowering the levels of poverty and updating Census data used to calculate aid for each school district, changes that he argues would drive more aid to high - needs districts.

The former Rector said upgraded polytechnics would be required to remain focused on their core function of training technicians and technologists at a higher level to meet the exigencies of the rapidly changing, technology - driven work environment.

If so, the interaction between hydrofracturing and ice - cliff collapse could drive global sea level much higher than projected in the Intergovernmental Panel on Climate Change (IPCC)'s 2013 assessment report and in a 2014 study led by Kopp.

There, he worked on the Montana Climate Assessment, a stakeholder - driven initiative to understand and explain climate change impacts at the state level.

If Lu's suggestion is correct, ozone levels should fall then rise every 11 years, in step with changes in cosmic - ray intensity driven by the 11 - year solar cycle.

Now, new research suggests changes at the epigenetic level — specifically alterations in proteins that affect gene expression, rather than genetic mutations — could be driving childhood ependymomas.

«This is the first study, to our knowledge, that demonstrates the mechanical continuity, strain transfer, and conformational changes that result from chemical energy release from the atomic scale up through the whole - cell level, as well as how tensegrity guides those changes to drive cellular movement,» says Ingber.

The Sun's activity — including changes in the number of sunspots, levels of radiation and ejection of material - varies on an eleven - year cycle, driven by changes in its magnetic field.

«Genetic changes help mosquitoes survive pesticide attacks: Study shows how intensive pesticide use is driving mosquito evolution at the genetic level.»

Using the genomic technologies he's learned at the IGB, Woolbright hopes to develop a research program that investigates climate - driven changes in species interactions at the gene level.

An open question is whether changes on the level of business or international politics can also drive changes in physiology — for instance, winning or losing wars, or economic booms and busts.

Climate change is driving the Greenland Ice Sheet to melt, which is contributing to sea level rise.

Researchers in Hawaii found that guppies released in the 1920s drove down native fish populations, perhaps by competing with them for food and living space, and had likely changed the cycle of nutrients in water: Guppy - rich areas showed increased levels of dissolved nitrogen — from ammonium in fish urine and gill excretions — which, in turn, stimulated algae growth.

In a recent paper, «Divergent Responses to Spring and Winter Warming Drive Community Level Flowering Trends,» researchers demonstrated that species were changing at both ends of the growing season.

They were able to show that episodes of extinction coincided with pulses of ocean anoxia, driven by changes in ocean circulation and nutrient levels.

Although snowstorms and rising sea levels garner more of the headlines about extreme weather driven by climate change, drought is quickly rising as the most troublesome, near - term impact.

There was also no link between food offered on a given day and the dunnart's torpor later the same day, showing that the change was driven by unpredictability, not short - term energy levels, says Munn.

These variations originate primarily from fluctuations in carbon uptake by land ecosystems driven by the natural variability of the climate system, rather than by oceans or from changes in the levels of human - made carbon emissions.

More information: R. S. Nerem el al., «Climate - change — driven accelerated sea - level rise detected in the altimeter era,» PNAS (2018).

[Response: Well, something like a circulation changed forced by the NAO pattern (which may in turn be affected by greenhouse gases) might cause an increase in European air temperatures, which in turn would allow low level moisture to increase if there is enough moisture supply, which would then constitute an amplification of a signal driven remotely.

The forces driving changes in global sea level are complex.

However, current levels of atmospheric CO2 are higher than those in the last 3 million years (Zhang et al. 2013), and these levels are likely to drive changes to climate (Solomon et al. 2009).

However, there is a caveat: semi-empirical models are inherently calibrated to the historical experience, and potentially biased if the processes that will dominate sea - level change in the future are qualitatively different from those that drove it in the past.

Cancer cells alter their metabolism in the interest of sustaining rapid growth, and high levels of PHGDH appear to drive such metabolic change.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

Paleoclimate data for sea level change indicate that sea level changed at rates of the order of a meter per century [81]--[83], even at times when the forcings driving climate change were far weaker than the human - made forcing.

Since heterogeneity in the tumor microenvironment, such as the presence of a neighboring blood vessel, may drive genetic changes, he reasoned that it might also be reflected on the level of proteins.

While the record 13.9 foot storm tide in New York Harbor during Superstorm Sandy was primarily due to the coincidence of the strongest winds with high tide, sea - level rise driven by historical climate change added more than one foot to that total.

Changes in the levels of male and female hormones can be caused by a variety of factors, and can result in erectile dysfunction (impotence) in men, and can be a cause of infertility and low sex drive in both sexes.

Another trial looked at a dosage of 32 mg per day, and found that the progesterone cream raised serum levels but did not change hot flashes, mood, or sexual drive.

If the insulin resistance is now driving the high insulin levels, even dietary changes may have a very modest effect on reducing the insulin levels.

Changes occur in your energy levels, metabolism, immune system, cardiovascular system, hormone levels and even sex drive.