Sentences with phrase «level mechanisms of the disease»

Not exact matches

«We have identified some 40 rare diseases where this mechanism can be produced at the level of similar trios of genes,» says Dr. Gueant.

The investigators suggest that the premature loss of estrogen caused by the oophorectomy may affect a series of aging mechanisms at the cellular and tissue level across the whole body leading to diseases in multiple systems and organs.

Complying with privacy laws, the mobile decision support system also will have a notification mechanism that will further inform people about the level of the alert in their specific areas and caution them as to where there is a disease outbreak within a geographic location.

Noise may disrupt the body on the cellular level in a way that increases the risk of common heart disease risk factors, according to a review topic published today in the Journal of the American College of Cardiology that examined the underlying mechanisms that may lead to noise - induced heart disease.

This call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to: ◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified ◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level Indeed, producing these models meets a key objective in the development of a therapeutic strategy.

The researchers also found the likely mechanism of disease progression in the Tob1 - deficient mice: higher levels of Th1 and Th17 cells, which cause an inflammatory response against myelin, and lower levels of Treg cells, which normally regulate inflammatory responses.

Transcriptome studies such as the National Institute of Health's Genotype - Tissue Expression (GTEx) program aim to overcome this limitation by studying gene expression levels and regulation mechanisms and their relationship with diseases, instead of only DNA sequence.

That damage accumulates with age to cause secondary effects, which in turn cause further issues, and by the time the process of dysfunction rises to the level of being called a disease it has become a huge mess of broken mechanisms, confusion, and dead ends.

«In a way, we're modeling one mechanism through which genes affect disease or traits, which is the regulation of gene expression level.»

In contrast, testosterone accelerates the development of nondiabetic chronic renal disease, and in streptozotocin - induced diabetic male rats, decreased testosterone levels and changes of sex hormone levels exacerbated the development of diabetic nephropathy, showing the importance of sex hormones in pathophysiologic mechanisms behind disease progression (334).

The Human Emulation System creates an environment where cells exhibit an unprecedented level of biological function, and gives researchers the ability to control complex human biology and disease mechanisms that is not possible with other techniques.

This technology creates an environment where the cells exhibit an unprecedented level of biological function, and provides control of complex human biology and disease mechanisms not possible with existing techniques.

Molecular mechanisms leading to pDC dysregulation and persistent type I IFN signature are largely unexplored, especially in systemic sclerosis (SSc), a disease in which pDCs infiltrate fibrotic skin lesions and produce higher levels of IFNα as compared to healthy controls.

Basis has been clinically proven to increase NAD + levels by 40 percent in a randomized trial (the results were published in Nature Partner Journals: Aging and Mechanisms of Disease.)

The specific mechanism of action has not been well documented though, as most studies have not drawn a clear line between blood levels of vitamin D and disease prevention.

The end result of these two mechanisms is that much more of the statin drug enters the systemic circulation than would normally be the case, leading to a build up in statin levels that can be quite dangerous, and may trigger a rare but serious statin - associated disease called rhabdomyolysis.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

Contributing author «An Integrative Approach to Late Stage Chronic Renal Disease Utilizing Photobiomodulation» Low Level Laser Therapy — the History, Mechanisms and Clinic Applications Creighton University School of Medicine (scheduled release 2017)