Sentences with phrase «levels decrease over time»

This is important because as men age their natural testosterone levels decrease over time.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The employment index climbed to 15.9 from 15.3, the part - time employment index decreased to 3.7 from 5.1, the hours worked index dipped to 8.0 from 8.3, the wages and benefits index grew to 23.5 from 20.9, the input prices index fell to 27.9 from 29.2, the selling prices index increased to 19.2, its highest level in over 10 years, from 17.0, the capital expenditures index slid to 16.0 from 17.6, the general business activity index rose to 14.5 from 13.4.

As the names imply, decreasing term policies pay a lower death benefit over time, while level term policies maintain the same death benefit for the term of the coverage.

A decreased glycemic response means your blood glucose levels are raised more slowly so your body will feed you energy over a longer period of time.

Finally, we have reviewed a large - scale study on high blood pressure showing an association between high levels of protein intake (in the vicinity of 100 grams per day) and significantly decreased risk of high blood pressure over an 11 - year period of time.

While some symptoms of blues will decrease over time once hormone levels are regulated, other women find themselves engulfed in a larger scale depression and may require medication to help them during this time.

Usually, the amount of milk required in the lactation aid increases over 1 to 2 weeks, then levels out for a variable period of time before decreasing.

[69] Research suggests that the antioxidant activity in expressed breast milk decreases over time, but remains at higher levels than in infant formula.

When a breastfeeding mother smokes, the nicotine levels in her blood and milk increase, and then decrease over time.

Sugar, fat, and calories increase in transitional milk over time and protein and antibodies decrease until mature milk levels are reached.

In fact, you should have observed the amount of foam quickly decrease over time, and probably saw the bottom level of the foam quickly rise to a higher level.

Declines in VA acuity over time were associated with increased mortality risk in part because of decreasing levels of IADL over time.

«Physical activity decreases over time at all levels of COPD severity, leading to further decline.»

Physical activity decreases substantially over time in patients with chronic obstructive pulmonary disease (COPD) at all levels of severity, according to a new study from researchers in Germany.

Though levels of these flame retardants are decreasing over time, investigators found PBDEs in every child blood sample.

For example, the model predicts that production of carbon dioxide must increase with time, a finding that goes against the conventional wisdom that carbon fluxes and atmospheric carbon dioxide levels have steadily decreased over the last 4 billion years.

When the water level decreases or stays static, fish production declines over time.

Red and orange colours indicate increasing ozone levels and blue colours indicate decreasing ozone levels over time.

The colour scale for increasing and decreasing ozone levels over time and associated p - values is the same as in Figure 8.

While the nutritional quality of our food and our activity levels have both decreased over time, our bodies may still behave like those of our ancestors.

What's more, the American Heart Association has concluded that a short walk in the park can decrease the risk of getting high blood pressure, increased cholesterol levels and can prevent the likelihood of developing diabetes if done consistently over time.

«We were happy to see that for most kids, the levels of victimization were lower overall or decreasing over time.

Reducing IGF - 1 levels has a direct on decreasing insulin which may reduce tumor growth and cancer over time by following a ketogenic diet.

As men age, their GH levels will slowly decrease over time, as opposed to a woman's hormones which will usually plummet quickly during menopause.

Many studies have shown the decrease of LDL levels over time eliminates aliments such as Type2 Diabetes.

Sometimes, this will take care of itself since your body weight is decreasing anyway but, especially with people who have a high level of physical activity, it's important to slowly decrease your caloric deficit over time.

When levels are higher than normal over a long period of time, this can cause a host of problems, including decreased liver function.

Over time and with age, the level of the testosterone decreases in the body leading to fatigue and obesity.

Having excess body fat is one of the factors that can lead to a decrease in natural testosterone levels over time.

Do you also feel like your energy levels, strength and stamina have decreased while your stress levels have increased over time?

But as you can see ketone levels continued to decrease over time to about 0.3 mmol / L as:

Although he supposedly retired to Tasmania in the early 2000s, it is very difficult to see a substantial decrease in his level of engagement or activity, though it did give him more time to write for such outlets as Senses of Cinema and communicate his passion for film history, as well as contemporary cinema, in a series of lectures or talks (I'm sure he'd prefer the latter term) held over a ten - year - period at the State Cinema in Hobart.

That's because most private insurers automatically decrease the level of coverage as the loan is paid off over time.

If interest rates decrease over time, to a level that is lower than your current mortgage rate, the time to «refi» may be here.

The insurer, in turn, is able to keep premiums level as the difference between the cash value and death benefit decreases over time, reducing their liability.

Decreasing term life insurance is less expensive than level term life insurance, but the death benefit decreases over time.

Chronic kidney failure causes many secondary problems over time, including a decrease in calcium levels that can lead to bone demineralization.

TNR provides benefits at three levels: the feral cats» lives are better, the neighbors» are calmer, and the size of the colonies decreases over time.

Over time, this decreased ability to breathe leads to low blood - oxygen levels, which puts a strain on the heart, and ultimately can lead to heart failure.

This implies that the CRF levels must have systematically decreased over time, causing a long - term decrease in the low cloud fraction and hence a long - term reduction in the planetary albedo, that again would be responsible for the warming.

It's very difficult to define optimal levels of consumption, so the idea should be to aim to decrease rates of growth, and modify this over time, depending on how fast we are using resources and encountering problems.

Albedo from medium / low level clouds warms or cools the ocean surface by increasing or decreasing over time across the global surface.

Although substantial interdecadal variability is present in the time series, long - term decreases in upper - level cloud cover occur over land and ocean at low and middle latitudes in both hemispheres.

Even if the earth's temperature had stayed the same or even decreased slighty over this time, ask yourself this: given what we know about the greenhouse effect and the levels of CO2 gases the world is creating, would you not be concerned that if we continue at the current rate, things are gonna get a hotter, eventually?

A store manager testified that store employees would occasionally have to refill the planter with river rock because the level of rock in the planter would decrease over time.

She struggled with recurring nightmares and accident related anxiety on a decreasing level over time.

The product to take note of is their Family Protection Plan - TI, which has level premiums as far as age 100 (though the benefit could decrease over time).

When the policy holder chooses the level death benefit, the value of the pure insurance component decreases over time to keep the death benefit the same while the policy's cash value increases.

Over time the benefit decreases, but the premium stays level.