Sentences with phrase «levels in normal mice»

And when researchers experimentally increased deltaFosB levels in normal mice, calbindin expression was suppressed and the animals» memory deteriorated, demonstrating that deltaFosB and calbindin are key regulators of memory.

The researchers then decided to see what would happen if they boosted sirtuin levels in normal mice as they aged.

Not exact matches

Cells engineered to produce insulin under the command of a smartphone helped keep blood sugar levels within normal limits in diabetic mice, a new study reports.

But unlike the normal mice, those with altered macrophages showed no signs of inflammation, such as changes in insulin production, high levels of immune chemicals, and macrophages in their belly fat.

They compared mice genetically engineered to have increased levels of SIRT6 with normal mice, engineering the mice in two different ways to control for genetic influences.

Alzheimer's mice with normal BACE1 levels experienced a steady increase in plaques, clearly seen in samples of their brains.

When the Stanford team measured pyrophosphate levels in cultured cells derived from ank and normal mice, they found that the chemical accumulated in cells from the ank mice but decreased in the culture medium.

In those normal mice, A-beta levels weren't as high as they were in the mutated mice, but the fact that they existed was notable, says study coauthor Weihong Song of the University of British Columbia in VancouveIn those normal mice, A-beta levels weren't as high as they were in the mutated mice, but the fact that they existed was notable, says study coauthor Weihong Song of the University of British Columbia in Vancouvein the mutated mice, but the fact that they existed was notable, says study coauthor Weihong Song of the University of British Columbia in Vancouvein Vancouver.

The authors said that this result suggests that the reason bacterial numbers are so high in these mice, and, by extension, human LAD patients, is not because of a defect in the immune system's surveillance mechanism but because of the inflammation caused by the immune system's abnormal response to normal levels of bacteria in the gums.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

By contrast, these females retained a normal level of social interest in other females during estrus, and in male mice when not in estrus.

«Just one transplant of the human EPO - producing cells treated kidney anaemia in mice, keeping their haemoglobin levels in the normal range for the remaining 7 - month lifespan of the animals,» says Kenji Osafune, of Kyoto University in Japan, who led the team.

«It was particularly exciting to see plasticity in the neurons impaired by mHTT,» said Davidson, noting that in the HD mice, brain areas that had begun to atrophy recovered volume and permitted better motor function after the researchers restored mTORC1 activity to more normal levels.

It restored normal blood sugar and insulin levels in animals that already had diabetes and prevented or slowed its onset in young mice that had not yet developed the disease.

In experiments with genetically engineered mice that lacked beta cells, reprogrammed stomach cells pumped out insulin and glucose at normal levels in the blooIn experiments with genetically engineered mice that lacked beta cells, reprogrammed stomach cells pumped out insulin and glucose at normal levels in the blooin the blood.

UBC Psychiatry Professor Dr. Weihong Song and Neurology Professor Yan - Jiang Wang at Third Military Medical University in Chongqing attached normal mice, which don't naturally develop Alzheimer's disease, to mice modified to carry a mutant human gene that produces high levels of a protein called amyloid - beta.

To solve this mystery, the scientists generated mice with normal or reduced levels of A2A receptors in astrocytes and compared them on tests of learning and memory.

Zeroing in on this kinase was encouraging, Goga said, because other researchers have shown that genetic - knockout mice that lack the entire family of PIM kinases are slightly smaller than normal mice, but «basically fine,» indicating that a drug targeting just PIM1 may have manageable levels of toxicity in breast cancer patients.

They found that levels of an enzyme involved in ketone metabolism, known as BDH1, were twice as high in mice with both early stage and complete heart failure compared to normal animals.

A study published January 4th in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long - term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with diabetes.

When they restored normal nitric oxide levels by having mice breathe in the short - lived gas — as patients have done in clinical trials — cell adhesion did not increase when oxygen levels decreased.

Next, Prins exposed the mice to elevated estrogen levels for two to four months, to mimic the normal rise in estrogen seen in aging men.

They found that the mice can develop damage to the optic nerve despite normal pressure in the eye following KPro surgery and identified TNFa and IL - 1 as inflammatory factors involved in this process, with high levels of TNFa mediating the damage to the optic nerve.

Exposure to low - oxygen air sends EPO levels soaring in normal mice, but these conditions did not induce a rise in the hormone in the animals without HIF - 1α, the researchers report in the 18 April issue of Cell.

When the researchers mimicked a systemic infection in mice, animals deficient in Del - 1 were slower to begin making myeloid cells again compared to those with normal Del - 1 levels.

With thoughts of a jolt fresh in their brain, mice with normal levels of α - CaMKII froze up when they returned to the chamber an hour later, while mice with boosted levels remained calm.

In this study, the researchers demonstrated that when normal mice were given kynurenine, they displayed depressive behaviour, while mice with increased levels of PGC - 1a1 in muscle were not affecteIn this study, the researchers demonstrated that when normal mice were given kynurenine, they displayed depressive behaviour, while mice with increased levels of PGC - 1a1 in muscle were not affectein muscle were not affected.

The researchers found that levels of a substance called 4 - ethylphenylsulfate that is produced by gut bacteria increased 46-fold in the mice with autistic symptoms, but returned to normal after treatment with B. fragilis.

The researchers are still trying to understand why they detected higher - than - normal fucose levels in Salmonella - infected mice.

In contrast, in mice with normal immune systems, emulsifiers induced low - grade or mild intestinal inflammation and metabolic syndrome, characterized by increased levels of food consumption, obesity, hyperglycemia and insulin resistancIn contrast, in mice with normal immune systems, emulsifiers induced low - grade or mild intestinal inflammation and metabolic syndrome, characterized by increased levels of food consumption, obesity, hyperglycemia and insulin resistancin mice with normal immune systems, emulsifiers induced low - grade or mild intestinal inflammation and metabolic syndrome, characterized by increased levels of food consumption, obesity, hyperglycemia and insulin resistance.

Monitoring groups of mice, one group receiving normal levels of protein in the diet and the other group nourished with low levels of protein for five weeks, researchers were able to uncover the damaging effect a reduction of protein can cause to the structure of this vital organ.

Jetlagged mice lacking a receptor called FXR, which keeps bile acid level in the liver within a normal physiological range, had higher bile acid levels and much more liver cancer.

The drug restored in the mice normal levels of serotonin, a neurotransmitter communicating messages between nerve cells in the brain.

They examined behaviors of the following types of mice: normal mice, AS model mice, mice that had reduced levels of the Na / K - ATPase, and AS model mice in which expression of the subunit of Na / K - ATPase was reduced.

To test potential remedies, the researchers examined phosphorylation of eIF2alpha in mice lacking PERK, hypothesizing that removal of this kinase would return protein synthesis to normal levels.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.

The team identified 186 different miRNAs, 11 of which were more highly expressed in the unhealthy mice than in normal mice, and five of which were expressed at lower levels than in normal mice.

After the mice received the MIF inhibitor, their blood sugar levels returned to normal, indicating that MIF is also pivotal in the progression of the disease.

The researchers found that in genetically - modified mice lacking Interferon - 1, who were also fed a high - fat diet, the CD8 + T cells did not produce an inflammatory response, and the mice had near normal blood sugar levels.

Indeed, those mice in Schwarzchild's study that were pretreated with caffeine retained near - normal dopamine levels when exposed to a chemical known to induce Parkinson's - like symptoms by decreasing brain dopamine.

The researchers also showed that DENV NS1 caused similar levels of blood vessel leak in normal mice as in mice bred to have inhibited cytokine activity, suggesting that cytokines were not necessary for this effect.

However, by the time these mice reached adulthood, around 8 months old, the level of photoreceptor cells in these knockout mice was less than half the normal level.

Interestingly NPGL levels, which plummeted in the 5 - week - long high - fat - diet mice — fell back to normal levels in mice who gorged themselves for the longer period of 13 weeks.

As seen through a microscope, the leg bone of a normal mouse (left) makes considerably less new bone than a mouse that produces high levels of a signaling protein, WNT7B, that stimulates new bone growth (shown in pink on the right).

This difference may be explained by the reduced levels of normal CST in obese mice compared to the lean control animals.

When mice were treated with an inhibitor of miR - 30a - 5p, however, the level of BDNF in the mPFC was restored to normal and alcohol consumption was restored to normal, moderate levels.

In contrast to studies that correlated elevated levels of IGF - 1 with the risk of developing prostate cancer, Greenberg's research showed that eliminating IGF - 1R expression in an otherwise normal mouse prostate caused the cells to proliferate and become hyperplastiIn contrast to studies that correlated elevated levels of IGF - 1 with the risk of developing prostate cancer, Greenberg's research showed that eliminating IGF - 1R expression in an otherwise normal mouse prostate caused the cells to proliferate and become hyperplastiin an otherwise normal mouse prostate caused the cells to proliferate and become hyperplastic.

Teh, H.S., Kishi, H. & von Boehmer, H. Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

The concentrations used in mice weren't justified or explained what the equivalent levels would be in humans i.e. is 50mg / kg the dose expected to be the safe / normal levels in humans?

In their study «D - Serine and Serine Racemase are Localized to Neurons in the Adult Mouse and Human Forebrain,» the lab utilized SR deficient (SR - / --RRB- mice, which have < 15 % of normal D - serine levels, to validate and optimize a D - serine immunohistochemical methoIn their study «D - Serine and Serine Racemase are Localized to Neurons in the Adult Mouse and Human Forebrain,» the lab utilized SR deficient (SR - / --RRB- mice, which have < 15 % of normal D - serine levels, to validate and optimize a D - serine immunohistochemical methoin the Adult Mouse and Human Forebrain,» the lab utilized SR deficient (SR - / --RRB- mice, which have < 15 % of normal D - serine levels, to validate and optimize a D - serine immunohistochemical method.