Sentences with phrase «levels in rodents»

Eating onions to increase testosterone levels may seem like a joke, but in a study that was conducted on rodents by Iranian scientists it was shown that onions can increase testosterone levels in rodents as high as 300 percent.

They have demonstrated that blood sugar levels in rodents can be controlled by the device.

(PDF [16]-RRB- There's even some evidence that certain mycotoxins have hormetic effects [17] at low levels in rodent ovarian cells, but that's not sufficient reason to go out and knowingly consume moldy corn or anything crazy like that.

Not exact matches

Neuroscientists have over the past decade uncovered evidence, both in rodent and human studies, that parental caregiving, especially in moments of stress, affects children's development not only on the level of hormones and brain chemicals, but even more deeply, on the level of gene expression.

With the support of her rodent - tolerant family, she studied the effects of varying thyroid hormone levels on the physical characteristics of a small rat colony she housed in her living room.

After transferring fecal matter from one group of rodents to another, they observed similar changes in the gut microbiota, acetate levels, and insulin.

When the EPA wants to set a pesticide standard, they have companies test the pesticide in rodents and measure what's called the no observed effect level — the NOEL — which becomes the threshold.

Using this biosensor in highly invasive breast cancer cells taken from rodents and humans, the Einstein team discovered that when an individual invadopodium forms and is actively degrading the ECM, its Rac1 levels are low; on the other hand, elevated Rac1 levels coincide with the invadopodium's disappearance.

In rodents it has been shown that serotonin (a naturally - occurring chemical commonly associated with feelings of happiness) plays a role in maintaining calcium levels; based on this, a team from the University of Wisconsin - Madison, led by Dr Laura Hernandez, investigated the potential for serotonin to increase calcium levels in both the milk and blood of dairy cowIn rodents it has been shown that serotonin (a naturally - occurring chemical commonly associated with feelings of happiness) plays a role in maintaining calcium levels; based on this, a team from the University of Wisconsin - Madison, led by Dr Laura Hernandez, investigated the potential for serotonin to increase calcium levels in both the milk and blood of dairy cowin maintaining calcium levels; based on this, a team from the University of Wisconsin - Madison, led by Dr Laura Hernandez, investigated the potential for serotonin to increase calcium levels in both the milk and blood of dairy cowin both the milk and blood of dairy cows.

Other rodent models that utilize changes in expression of α - synuclein have also reported lower anxiety levels.

«Rodents, dogs and other mammals commonly sniff themselves, and they sniff one another in social interactions, and it seems that in the course of evolution, humans have retained this practice — only on a subliminal level.»

In a study published last fall, researchers showed that male prairie voles that had been separated from their female partners for four days — a much shorter amount of separation time than researchers had previously found to affect the voles» physiology — exhibited depressionlike behavior and had increased levels of corticosterone, the rodent equivalent of the human stress hormone cortisol.

Afterward, in tests to see if the mice displayed the rodent equivalent of anxiety and depression symptoms, they found about 40 percent showed high levels of behaviors that included a preference for a dark compartment over a brightly lit one, or a loss of interest in sugar water.

Using rodent models of opiate addiction, Dr. Laviolette's research has shown that opiates affect pathways of associative memory formation in multiple ways, both at the level of anatomy (connections between neurons) and at the molecular levels (how molecules inside the brain affect these connections).

In this proteomic study, Jianyun Yu, Hu Zhou and colleagues assessed brain protein levels after one or more concussions in rodents at multiple timepointIn this proteomic study, Jianyun Yu, Hu Zhou and colleagues assessed brain protein levels after one or more concussions in rodents at multiple timepointin rodents at multiple timepoints.

«Stem cell strategy for boosting testosterone levels tested in rodents.»

Sladek explained that some of the negative metabolic effects of animal fat that researchers often see in rodents could actually be due to high levels of linoleic acid, given that most U.S. farm animals are fed soybean meal.

Neurologist Jimo Borjigin of the University of Michigan, Ann Arbor, got interested in near - death experiences during a different project — measuring the hormone levels in the brains of rodents after a stroke.

Rats and mice in pain make facial expressions similar to those in humans — so similar, in fact, that a few years ago researchers developed rodent «grimace scales,» which help them assess an animal's level of pain simply by looking at its face.

After 3 weeks, the team measured the levels of gut - derived molecules in the rodents» bloodstream and found that the treatment had stopped up their intestinal leakage.

The treated rodents were not only fatter but also suffered elevated levels of fasting insulin, and alterations in genes related to liver regeneration and detoxification — effects consistent with metabolic disorders in obese patients.

Pulsing blue light upon the mice for 48 hours led to an increase in the rodents» insulin levels and better tolerance of glucose compared with control mice.

The selective loss of large herbivores, for instance, is known to cause relatively systematic increases in abundance of rodents [71], which are thought to be particularly effective at hosting and transmitting human - borne zoonoses, thus driving landscape - level increases in rodent - borne disease [72].

Being able to generate their own heat, these small rodent - like creatures did not need to bask in the sun to raise their body temperature and activity levels, so nocturnal life was an option — and an appealing one.

«Laboratory rodent diets contain toxic levels of environmental contaminants: implications for regulatory tests» by Robin Mesnage et al. published in PLOS ONE on Thursday 2 July 2015.

«The levels and duration of exposure to radiofrequency radiation were much greater than what people experience with even the highest level of cell phone use, and exposed the rodents» whole bodies,» said NPT in a statement.

MALDI - MS analysis revealed an absence of Aβ signal in non-transgenic animals (Figure 5) at both time points, indicating that detected Aβ peptides predominantly derive from the human APP transgene expression or reflecting the low level of endogenous rodent Aβ [51].

Telomere length predicts both cellular health and disease in rodent models and humans.8 Shorter telomeres predict onset of cardiometabolic diseases of aging.9 Chronic stress is associated with higher inflammation, shorter telomeres, and lower activity levels of telomerase, the cellular enzyme that elongates telomeric DNA.10, 11 Levels of amyloid beta (Aβ) proteins circulating in the blood appear to be stress - related in rodent models12 and may be affected by stress reduction, and greater Aβ42 / Aβ40 ratios are associated with lower risk of demenlevels of telomerase, the cellular enzyme that elongates telomeric DNA.10, 11 Levels of amyloid beta (Aβ) proteins circulating in the blood appear to be stress - related in rodent models12 and may be affected by stress reduction, and greater Aβ42 / Aβ40 ratios are associated with lower risk of demenLevels of amyloid beta (Aβ) proteins circulating in the blood appear to be stress - related in rodent models12 and may be affected by stress reduction, and greater Aβ42 / Aβ40 ratios are associated with lower risk of dementia.13

Another rodent study showed that administration of B. infantis in rats reduced the levels of IFN - γ, TNF - α, and IL - 6 following mitogen stimulation and altered tryptophan, 5 - HIAA, and DOPAC levels in the frontal cortex and amygdala [37].

Paul Sawchenko uses cell biological and genetic approaches in rodent models to study how stress - responsive systems are organized at a molecular level within the body and particularly within the brain.

Writing in American Naturalist in 1939, he noted that «it has been difficult to keep at fever heat a sufficient level of sympathy for the rodent similar to that which the dog or cat engenders.»

Compared to ad libitum fed controls, rodents maintained on IER (100 % ER / alternate days) for periods of 12 to 24 weeks typically exhibit lower post-treatment levels of fasting glucose 14, 16, 17, 29 and insulin.16, 17, 29 Using this particular IER protocol, Jiang et al28 have also demonstrated an increase in oral glucose tolerance and tissue insulin sensitivity (measured using a hyperinsulinemic - euglycemic clamp) after four weeks in healthy rats.

Studies in rodents have additionally described post-treatment elevations in the rate of fatty acid oxidation within both the liver and skeletal muscle of mice maintained on IER (100 % ER / alternate days).13 In a comparison of CER (40 % ER / day) and IER (100 % ER / alternate days), the authors of this 20 - week study noted a doubling in the Î ² - hydroxybutyrate levels (a marker of mitochondrial fatty acid oxidation) in IER - fed mice which was not present in the CER group.15 Both IER and CER interventions led to comparable reductions in fasting levels of glucose and insuliin rodents have additionally described post-treatment elevations in the rate of fatty acid oxidation within both the liver and skeletal muscle of mice maintained on IER (100 % ER / alternate days).13 In a comparison of CER (40 % ER / day) and IER (100 % ER / alternate days), the authors of this 20 - week study noted a doubling in the Î ² - hydroxybutyrate levels (a marker of mitochondrial fatty acid oxidation) in IER - fed mice which was not present in the CER group.15 Both IER and CER interventions led to comparable reductions in fasting levels of glucose and insuliin the rate of fatty acid oxidation within both the liver and skeletal muscle of mice maintained on IER (100 % ER / alternate days).13 In a comparison of CER (40 % ER / day) and IER (100 % ER / alternate days), the authors of this 20 - week study noted a doubling in the Î ² - hydroxybutyrate levels (a marker of mitochondrial fatty acid oxidation) in IER - fed mice which was not present in the CER group.15 Both IER and CER interventions led to comparable reductions in fasting levels of glucose and insuliIn a comparison of CER (40 % ER / day) and IER (100 % ER / alternate days), the authors of this 20 - week study noted a doubling in the Î ² - hydroxybutyrate levels (a marker of mitochondrial fatty acid oxidation) in IER - fed mice which was not present in the CER group.15 Both IER and CER interventions led to comparable reductions in fasting levels of glucose and insuliin the Î ² - hydroxybutyrate levels (a marker of mitochondrial fatty acid oxidation) in IER - fed mice which was not present in the CER group.15 Both IER and CER interventions led to comparable reductions in fasting levels of glucose and insuliin IER - fed mice which was not present in the CER group.15 Both IER and CER interventions led to comparable reductions in fasting levels of glucose and insuliin the CER group.15 Both IER and CER interventions led to comparable reductions in fasting levels of glucose and insuliin fasting levels of glucose and insulin.

Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of cellular stress resistance and improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20, survival following induced ischaemic injury 21 and a reduction in oxidative stress.105

Several trials have demonstrated that the cardiomyocytes of rodents maintained on IER become more resilient to ischaemic injury induced by occlusion of the left coronary artery 18, 21, 29, which translated into improved long - term survival following such injury in one study.21 In addition, within these studies, associations have been found between the cardiovascular improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular healtin one study.21 In addition, within these studies, associations have been found between the cardiovascular improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular healtIn addition, within these studies, associations have been found between the cardiovascular improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular healtin circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular healtin biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular health.

Leptin levels in human and rodent: measurement of plasma leptin and ob NAN in obese and weight - reduced subjects.

Conversely, when spexin levels are regulated, gut motility improves along with food intake, energy metabolism, and regulation of fat storage, particularly long chain fatty acid uptake in fat cells.6 Walewski, J. L., et al. «Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents... continue

All members of the two most popular classes of lipid - lowering drugs (the fibrates and the statins) cause cancer in rodents, in some cases at levels of animal exposure close to those prescribed to humans.

Similarly, in a rodent model of PCOS, levels of ERβ protein were decreased in the granulosa layers of cystic follicles.67 Idiopathic ovulatory dysfunction has been found to be associated with a G / A (1730) polymorphism in ERβ.2.

While alternate - day fasting leads to calorie restriction over a two - day period in many rodent species, in some strains of mice, the animals managed to compensate for the calorie deficit created on fast days by increasing their intake on feast days twofold and thus keeping the total calorie intake over a two day period at the same level as in mice fed an ad libitum diet (17).

Do high levels of certain amino acids lead to higher cancer rates in rodents?

But this goes beyond just rodents... they have also shown that there is probably also low - level inflammation occurring in the brains of obese humans (6).

He's found that intermittent fasting in rodents seems to improve their blood sugar levels, boost performance on cognitive tasks and help keep them lean.

Less common are rodent poisons that drive up the level of calcium in the body and cause kidney failure.

Conditions in the home are often deplorable and can include furniture and flooring covered in feces and urine; presence of sick, dying or deceased animals; rodent or bug infestations; high levels of ammonia in the air; lack of clean food and water; and deteriorating conditions within the home (e.g. lack of plumbing, broken appliances).

What surprised the authors of the new study were the levels of fructose molecules found in the oxygen - deprived rodents.

The most critical findings are that, in rodents, (i) functional enhancement during adulthood across diverse functional domains at both behavioral and neuroendocrine levels can be induced by repeated neonatal exposures to a relatively novel nonhome environment; and (ii) these functional improvements occurred in the absence of evidence of preferential maternal care and, more importantly, in the presence of direct evidence for lesser maternal care relative to home - staying siblings.

Around the time of birth in most mammals, changes to the hormonal milieu including fluctuating levels of estrogen, 19,20 progesterone19, 20, prolactin21 and oxytocin22 trigger a cascade of neurological adaptations that result in typical maternal behaviour.23 Numan, and colleagues,24 - 29 have demonstrated that the neurobiology of mothering in rodents relies heavily on projections from the medial preoptic area of the hypothalamus and bed nucleus of the stria terminalis, as well as fibres from surrounding sensory, limbic and cortical systems.