Not exact matches
Measurements of fetal
levels of maternally infused stable isotope - labeled
myo - inositol in normal pregnancies at term demonstrated that less than 10 % of fetal inositol was maternally derived, suggesting little placental transport in late pregnancy (19)»
It comes in two forms:
myo - inositol and d - chiral inositol, both of which have been shown to significantly reduce insulin
levels and improve hormonal balance in PCOS (25, 26, 27).
In addition to lowering glucose and insulin
levels,
MYO has been shown to improve lipid and androgen
levels, blood pressure and egg quality in women with PCOS.
In this direct comparison that included patients both with and without insulin resistance,
myo - inositol outperformed metformin when it came to reducing testosterone
levels, hirsutism, and markers of inflammation (Jamilian et al. 201719).
Studies have shown that
myo - inositol can improve insulin and glucose
levels in women with PCOS.
Venturella et al showed that 2 g / day of
MYO for six months resulted in significant weight loss and improved HDL and LDL
levels.48
MYO at 1,200 mg / day for 12 weeks significantly decreased androgens and insulin in non-obese women with PCOS.
One large randomized, double - blind, placebo - controlled trial showed that
MYO (4 g / day) for 14 weeks, increased HDL («good» cholesterol)
levels and resulted in significant weight loss (and decreased leptin
levels) in women with PCOS, although no change in insulin was detected.
That's why it's now recommended that women with PCOS supplement with both
myo and DCI in a 40:1 ratio, that mimics the body's natural physiological
levels.
In another study, a combination of
myo - inositol, D - chiro - inositol, and other nutrients decreased the risk of gestational diabetes among women with elevated first trimester fasting blood sugar
levels.11
There is a DCI Paradox that PCOS ovaries convert
Myo into DCI at increased rates, depleting
myo levels resulting in an overproduction of DCI
levels, which may cause poor egg quality.