Mice that were deprived of either RbAp48 or osteocalcin exhibited poorer recall, and healthy
levels of osteocalcin correlated to better memory in both young and old animals.
This is explained by another finding from the Karsenty lab: circulating
levels of osteocalcin are much higher in younger mice than in older mice.
She notes, however, that the researchers did detect increased
levels of osteocalcin, a hormone that indicates bone formation.
Women's blood
levels of osteocalcin increased during exercise, the team reported.
Not exact matches
TE and WBV increased circulating
osteocalcin in db / db mice, relative to SED db / db mice, but did not restore
levels to within the range
of WT mice.
Metagenics Ostera has been clinically shown in a study
of postmenopausal women with low estrogen
levels to support key markers
of bone remodeling, positively influence
osteocalcin, and offer more effectiveness than diet and exercise alone.
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The Opotowski team, which found that low vitamin A
levels had as great an effect lowering BMD as did high vitamin A
levels, suggested that vitamin A deficiency may contribute to increased fracture risk by allowing bone matrix to grow faster than it can be mineralized.12 Indeed, although the net effect
of vitamin A is to stimulate osteoclasts and slow the growth
of osteoblasts, vitamin A also causes osteoblasts to secrete a variety
of enzymes and other proteins that are important to bone mineralization, including
osteocalcin, which is a protein that plays a direct role in attracting and binding calcium within the bone matrix.6 By slowing the growth
of the matrix but increasing the rate at which it is mineralized, adequate vitamin A helps to ensure sufficient bone density.