Lawrence expects that the spacecraft will significantly shrink
levels of uncertainty for such cosmological parameters as the age of the universe and the relative proportions of ordinary matter (all that we can see and touch) and that mysterious stuff known as dark matter, which is believed to make up far more of the universe than its ordinary counterpart.
With action on the back - burner until after the federal election, New York Farm Bureau Spokesman Steve Ammerman says there is a high
level of uncertainty for farmers.
Not exact matches
Speaking to the influx
of investment by the world's largest technology companies into the U.K. as Facebook, Google and Apple all recently announced greatly expanded plans
for London headquarters and staffing
levels, Marshall said the technology sector is more able to cope with the
uncertainty wrought by Brexit.
Because
of these
uncertainties, there is no single best metric
for the
level of liquidity in a market.»
Actual results and the timing
of events could differ materially from those anticipated in the forward - looking statements due to these risks and
uncertainties as well as other factors, which include, without limitation: the uncertain timing
of, and risks relating to, the executive search process; risks related to the potential failure
of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies
of eptinezumab sufficient to achieve a positive completion; the availability
of data at the expected times; the clinical, therapeutic and commercial value
of eptinezumab; risks and
uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and
uncertainties relating to the manufacture
of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights
of others; the uncertain timing and
level of expenses associated with Alder's development and commercialization activities; the sufficiency
of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K
for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.
Such risks,
uncertainties and other factors include, without limitation: (1) the effect
of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates,
levels of end market demand in construction and in both the commercial and defense segments
of the aerospace industry,
levels of air travel, financial condition
of commercial airlines, the impact
of weather conditions and natural disasters and the financial condition
of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization
of the anticipated benefits
of advanced technologies and new products and services; (3) the scope, nature, impact or timing
of acquisition and divestiture or restructuring activity, including the pending acquisition
of Rockwell Collins, including among other things integration
of acquired businesses into United Technologies» existing businesses and realization
of synergies and opportunities
for growth and innovation; (4) future timing and
levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability
of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope
of future repurchases
of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the
level of other investing activities and uses
of cash, including in connection with the proposed acquisition
of Rockwell; (7) delays and disruption in delivery
of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits
of organizational changes; (11) the anticipated benefits
of diversification and balance
of operations across product lines, regions and industries; (12) the outcome
of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact
of the negotiation
of collective bargaining agreements and labor disputes; (15) the effect
of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect
of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect
of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act
of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability
of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition
of conditions that could adversely affect the combined company or the expected benefits
of the merger) and to satisfy the other conditions to the closing
of the pending acquisition on a timely basis or at all; (18) the occurrence
of events that may give rise to a right
of one or both
of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee
of $ 695 million to United Technologies or $ 50 million
of expense reimbursement; (19) negative effects
of the announcement or the completion
of the merger on the market price
of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation
of their businesses while the merger agreement is in effect; (21) risks relating to the value
of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability
of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.
The S&P 500 Index should still produce healthy gains
for the full year, though political
uncertainty has introduced a
level of volatility in the near term, says Calvasina.
«Anytime there is that
level of uncertainty around pricing a risk, it's sure to cause hesitation
for the underwriters.»
Actual results, including with respect to our targets and prospects, could differ materially due to a number
of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality
for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political
uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand
for our products; product mix; risks associated with the ramp - up
of production
of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception
of our brand and products, resulting in lower demand
for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall
of our products; ongoing
uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability
of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration
of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers
of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits
of the transaction; the risk that retail customers may alter promotional pricing, increase promotion
of a competitor's products over our products or reduce their inventory
levels, all
of which could negatively affect product demand; the risk that our investments may experience periods
of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity
of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization
of products under development, such as our pipeline
of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods
for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development
of new technology and competing products that may impair demand or render our products obsolete; the potential lack
of customer acceptance
for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K
for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.
These risks and
uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues
for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement
for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount
of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability
of funding
for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction
of generic versions
of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect
of lowering prices or reducing the number
of insured patients; the possibility
of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the
levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits
of the Sangamo partnership; Gilead's ability to submit new drug applications
for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all,
for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages
of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development
of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate
of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
These risks and
uncertainties include competition and other economic conditions including fragmentation
of the media landscape and competition from other media alternatives; changes in advertising demand, circulation
levels and audience shares; the Company's ability to develop and grow its online businesses; the Company's reliance on revenue from printing and distributing third - party publications; changes in newsprint prices; macroeconomic trends and conditions; the Company's ability to adapt to technological changes; the Company's ability to realize benefits or synergies from acquisitions or divestitures or to operate its businesses effectively following acquisitions or divestitures; the Company's success in implementing expense mitigation efforts; the Company's reliance on third - party vendors
for various services; adverse results from litigation, governmental investigations or tax - related proceedings or audits; the Company's ability to attract and retain employees; the Company's ability to satisfy pension and other postretirement employee benefit obligations; changes in accounting standards; the effect
of labor strikes, lockouts and labor negotiations; regulatory and judicial rulings; the Company's indebtedness and ability to comply with debt covenants applicable to its debt facilities; the Company's ability to satisfy future capital and liquidity requirements; the Company's ability to access the credit and capital markets at the times and in the amounts needed and on acceptable terms; and other events beyond the Company's control that may result in unexpected adverse operating results.
Throughout this period, companies have been dealing with high
levels of uncertainty about the prospects
for the global economy, in some cases because
of aggressive deleveraging.
Risks associated with the Consumer Discretionary sector include, among others, apparel price deflation due to low - cost entries, high inventory
levels and pressure from e-commerce players; reduction in traditional advertising dollars; increasing household debt
levels that could limit consumer appetite
for discretionary purchases; declining consumer acceptance
of new product introductions; and geopolitical
uncertainty that could impact consumer sentiment.
And given the amount
of uncertainty at the entrepreneurial
level, to lock and load that relationship at that stage is usually a cause
for disaster.
Such risks and
uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact
of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits
of such transactions, including with respect to the Merger; the substantial
level of government regulation over our business and the potential effects
of new laws or regulations or changes in existing laws or regulations; the outcome
of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments;
uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security
of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts
of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required
for the Merger or the requirement to accept conditions that could reduce the anticipated benefits
of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration
of the businesses
of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion
of management's attention from ongoing business operations and opportunities during the pendency
of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability
of financing, including relating to the proposed Merger; effects on the businesses as a result
of uncertainty surrounding the proposed Merger; as well as more specific risks and
uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section
of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section
of www.express-scripts.com.
The
level of uncertainty and volatility in financial markets will likely remain elevated
for quite some time.
Prices move inversely proportional to shifts in economic
uncertainty so that expected returns remain essentially the same
for a given
level of risk.
He also said plenty
of uncertainty remains over where the neutral
level for interest rates actually is.
Although US Treasuries have been sliding since the beginning
of the year, the
uncertainty and volatility that we have seen in the past few weeks have pushed yields back down, forcing 10 - year Treasuries to close last week at 2.77 % — a
level far away from the psychological 3 %
level many have been waiting
for.
Both studies came to the same basic conclusion: that the risks and
uncertainties involved in budget forecasting were simply too large to allow
for a high
level of forecast accuracy.
The degree
of uncertainty for businesses today probably is at the highest
level in decades.
The reason
for Australia's third - ranking iron ore miner traditionally being seen more as prey than predator is a function
of its once sky - high debt
levels,
uncertainty about its ore grade, and a belief that at some point Forrest would be tempted to cash out
of the company he created.
Examples
of these risks,
uncertainties and other factors include, but are not limited to the impact
of: adverse general economic and related factors, such as fluctuating or increasing
levels of unemployment, underemployment and the volatility
of fuel prices, declines in the securities and real estate markets, and perceptions
of these conditions that decrease the
level of disposable income
of consumers or consumer confidence; adverse events impacting the security
of travel, such as terrorist acts, armed conflict and threats thereof, acts
of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread
of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment
of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount
of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion
of our assets pledged as collateral under our existing debt agreements and the ability
of our creditors to accelerate the repayment
of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss
of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price
of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy
levels at different times
of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements
for crew members and other employee relation issues; the continued availability
of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.
For example, the idea that the brain is a complex non-linear dynamic system is mentioned only fleetingly - leaving me with the feeling that we had missed an opportunity for a useful discussion (such as perhaps making a connection with the ideas advocated by Polkinghorne regarding the possibility of chaotic systems «amplifying» quantum level uncertainties up to the macro-leve
For example, the idea that the brain is a complex non-linear dynamic system is mentioned only fleetingly - leaving me with the feeling that we had missed an opportunity
for a useful discussion (such as perhaps making a connection with the ideas advocated by Polkinghorne regarding the possibility of chaotic systems «amplifying» quantum level uncertainties up to the macro-leve
for a useful discussion (such as perhaps making a connection with the ideas advocated by Polkinghorne regarding the possibility
of chaotic systems «amplifying» quantum
level uncertainties up to the macro-
level).
Does the author apply this same
level of ambiguity and
uncertainty to any other writings
of antiquity (
for which there exists far less manuscript evidence)?
Mr Droppert said the EU had started accepting a few tenders
for the SMP intervention and this injected a
level of «
uncertainty» in the market.
However, when a hierarchy that's been in place
for over two decades is upended, there's an especially high
level of uncertainty that comes with the coaching change — no matter who's brought in.
Overall, however, there may be one million people voting
for the first time in the 2014 referendum, introducing an unprecedented
level of uncertainty.
Many no doubt will argue that this high sum traded - off
uncertainty for genuine anxiety amongst many voters, and that a lower
level of basic income may have been a more prudent approach.
There is no doubt that we are in a time
of particular challenge
for business, not least because
of the current
level of uncertainty around Brexit.
There isn't a good scientific body
of evidence that someone could pick up their blood PFOA
level and say «OK, well this means my risk
for some health outcome is x, y or z,» and scientists can't provide that and this is one
of the places where we'll have to say we don't know and there is
uncertainty about that.»
«In this period
of austerity, national economic
uncertainty, unpredictability
of federal funding, and rising social service costs there is an increasing risk that funding
for infrastructure investments will be curbed to dangerous
levels,» Ravitch said in a press release.
«In the face
of unprecedented
uncertainty from the federal
level, your partnership is more important than ever,» Mr. de Blasio told his audience, making a plea
for unity to a legislative body that — on the Republican - controlled State Senate side, at least — has never had much use
for him.
The
level of agita over the mayor's role in campaigns outside the city underscores the
uncertainty over the Senate: The Republicans, who have ruled the chamber
for most
of past 50 years, are clinging to power only by dint
of an alliance with a Democrat, Simcha Felder
of Brooklyn.
«There's so much anxiety because
of the
uncertainty at the federal
level, especially
for those who depend on support from government.
Using a representative sample
of 20 different methods
for predicting extreme sea
levels the researchers focused intensely on the measures
of uncertainty that accompany any prediction, but that are particularly vexing in the analysis
of extremes.
Some
level of uncertainty is par
for the course in the world
of do - it - yourself chemistry, which has seen the number
of entrepreneurial alchemists explode in the years since Patrick Arnold gulped down his first chemical concoction and went on to become one
of America's most notorious underground chemists.
A major criticism
of Russell's view
of uncertainty as God's tool
for shaping the world is that quantum events usually play out only on the subatomic
level.
«People are likely to react with little fear to certain types
of objectively dangerous risk that evolution has not prepared them
for, such as guns, hamburgers, automobiles, smoking, and unsafe sex, even when they recognize the threat at a cognitive
level,» says Carnegie Mellon University researcher George Loewenstein, whose seminal 2001 paper, «Risk as Feelings,» (pdf) debunked theories that decision making in the face
of risk or
uncertainty relies largely on reason.
The new approach contrasts with previous ways scientists analyzed and came to conclusions about sea
level rise because it is «the only proper one that aims to fully account
for uncertainty using statistical methods,» noted Parnell, principal investigator
of the study conducted collaboratively with researchers at Tufts University, Rutgers University and Nanyang Technological University.
For example, genetically engineered organisms used in the research laboratory to develop new chemical synthesis methods are not likely to require the same
level of public dialogue as products that have more
uncertainty associated with them, such as organisms with gene drives, which enhance organisms» ability to pass certain genetic traits on to their offspring.
Also, the model - based approach includes measures
of uncertainty about our population estimates, which are not usually provided by more common approaches and are crucial
for understanding the
level of confidence we have about our estimates.»
This
level of outlook is reserved
for the most extreme cases, with the least
uncertainty, and is only used when the possibility
for extremely explosive storms is detected.
The debate in the media expresses far less
uncertainty in this issue than is customary
for this
level of scientific inquiry.
Those data, to be collected this year and next, could improve climate models, which account poorly
for these atmospheric interactions and contain «horrific»
uncertainties about the
levels and behaviour
of water vapour at stratospheric altitudes, Austin says.
«The tide gauge measurements are essential
for determining the
uncertainty in the GMSL (global mean sea
level) acceleration estimate,» said co-author Gary Mitchum, USF College
of Marine Science.
«(A) the technical capacity to monitor, measure, report, and verify forest carbon fluxes
for all significant sources
of greenhouse gas emissions from deforestation with an acceptable
level of uncertainty, as determined taking into account relevant internationally accepted methodologies, such as those established by the Intergovernmental Panel on Climate Change;
These risks and
uncertainties include, among others, those relating to our ability to obtain financing and to form collaborative relationships,
uncertainty regarding potential future deterioration in the market
for auction rate securities which could result in additional permanent impairment charges, our ability to develop and market diagnostic products, the
level of third party reimbursement
for our products, risks related to preclinical and clinical development
of pharmaceutical products, including the identification
of compounds and the completion
of clinical trials, the effect
of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights
for our products, dependence on collaborative relationships, the effect
of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.
For the assessments
of climate impacts made herein, we follow guidance from the National Climate Assessment and Intergovernmental Panel on Climate Change (IPCC) on how to standardize confidence
levels and
uncertainty characterization in our key messages, as provided below.
These risks and
uncertainties include, among others, those relating to our ability to obtain sufficient financing to continue as a going concern, our ability to develop and market diagnostic products, the
level of third party reimbursement
for our products, risks related to preclinical and clinical development
of pharmaceutical products, including the identification
of compounds and the completion
of clinical trials, our ability to form collaborative relationships, the effect
of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights
for our products, dependence on collaborative relationships, the effect
of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.