Sentences with phrase «levels than normal cells»

«Tumor cells produce larger quantities of H2O2 and use oxidative signals at higher levels than normal cells in order to drive their own growth,» says Mirko Sobotta, first author of the publication.

Not exact matches

His lab differentiates iPSCs from autistic patients into neurons and glial cells, which they suspect may be releasing cytokines at levels higher than normal in autistic patients.

The metabolism of bone cells determines how much sugar they use; if the bone cells consume more sugar than normal, this can lower the glucose level in the blood.

Researchers found that CML stem cells accumulate significantly higher levels of certain dipeptide species than do normal hematopoietic stem cells.

After 10 days of age, the manipulations reduced the distance flies could climb up tubes and the alterations caused older flies to have signs of neurodegeneration, including higher than normal levels of brain cell death and degradation.

They found that normal cells grow faster when in an organoid with cells expressing RasG12V at low levels, but required more than one mutant cell to kick - start this abnormal growth.

The toxicity of chokeberry extract on normal blood vessel lining cells was tested and found to have no effects up to the highest levels used (50 ug / ml), suggesting that the cell death effect is happening in a way other than through preventing new blood vessel formation (anti-angiogenesis), a process that is important in cancer cell growth.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.

However, by the time these mice reached adulthood, around 8 months old, the level of photoreceptor cells in these knockout mice was less than half the normal level.

The researchers found much higher levels of heparanase in childhood brain tumours than in the normal brain, and furthermore, a molecule that can block this enzyme induces cell death in medulloblastoma cells in culture, while normal brain cells were not affected.

Preliminary studies have shown that AML stem cells produce higher levels of CD47 than normal healthy cells, and that treatment with antibodies to block CD47 allows the immune system to destroy AML cells without harming healthy cells.

Morphologically the majority of V + cells grown in the presence of LIF appear indistinguishable from their V − counterparts and the level of fluorescence in these morphologically normal V + cells is substantially lower than that observed in cells that either appear differentiated or have been differentiated in response to LIF withdrawal (Figure 2B).

Since uncontrolled cancer cells proliferate faster than normal cells, and since serum cholesterol levels drop so precipitously when cancer takes hold, they are apparently especially thirsty for serum lipids.

As a result, one could argue that things would run the opposite way than Adele proposes: reducing dietary glucose, which generally does not reduce blood glucose levels, will not affect cancer metabolism, but will limit availability of glucose to normal cells for structural use.

I am not a fan of sulfonylurea drugs, because the problem in Type 2 diabetes is not that you don't make enough insulin, it's that your cells are resistant to insulin, and in fact your insulin levels are HIGHER than normal.

When you produce higher than normal levels of antibodies to certain parts of the body (it's normal for old and dying cells to be tagged for removal), this means you are having an autoimmune reaction against that tissue or enzyme.

It is characterized by higher than normal levels of white blood cells, specifically lymphocytes, plasma cells, neutrophils, or eosinophils in the walls of the intestine.