Sentences with phrase «library screening in»

We then retested the nine hits from the NINDS library screening in 96 - well plates.

Not exact matches

December 23: Take in a showing of The Polar Express on the library's big screen with surround sound (Waltham)

At 11 a.m., NYC Administration for Children's Services Commissioner David Hansell announces a new partnership with NYU College of Dentistry to provide dental screenings to children in foster care, Nicholas Scoppetta Children's Center, fourth floor library, 492 First Ave., Manhattan.

David Sinclair of Harvard Medical School in Boston and colleagues at the biotech firm BIOMOL Research Laboratories in Plymouth Meeting, Pennsylvania, screened a library of compounds for molecules that trigger SIRT1 activity.

«The lipidoid material screen is just an example demonstrated in this article; a similar strategy can be readily extended to other libraries or other organ systems,» Peng adds.

In this study, the researchers screened a library of 200,000 small molecule compounds to identify potential inhibitors of Ebola virus RNA synthesis.

In 1998, for example, Wiman's team screened a library of 2000 compounds from the U.S. National Cancer Institute and found two that appeared to restore mutant p53's ability to kill cancer cells.

To find new compounds for spraying and nets, IVCC has partnered with several large chemical companies including BASF, Syngenta, and Sumitomo to screen more than 4 million compounds in their libraries.

This work began as part of a biodefense grant from the National Institutes of Health, screening a library of 30,000 compounds for activity against the envelope of Nipah virus, an emerging infection first identified in 1999 in Malaysia.

When researchers screened a library of more than 200 drugs and related compounds for activity against embryonal subtype tumor cells from three patients, the most promising results involved drugs that increased oxidative stress in tumor cells.

Today, the pharmaceutical industry screens synthetic chemical libraries of thousands of molecules to find one that may have a medicinal effect, said Parekkadan, who joined Rutgers» School of Engineering in January.

For instance, it may soon be possible to automatically separate all of the chemicals in an organism, identify them, and catalogue them in a library for future screening.

Using a robotics - based screening approach, researchers screened a library of 1,192 FDA - approved drugs for any that suppressed tumors in the fly and identified several that improved overall survival.

Companies in the partnership supply compound libraries and drug discovery expertise to the effort, while academic partners contribute knowledge about the disease and facilities for screens and assays.

The researchers created a large library of MphR protein variants and screened them for the ability to switch on production of a fluorescent green protein when they were in the presence of a desired macrolide.

A new technique of direct binding of radioactive DNA was used to screen a complementary DNA expression library from the BJAB cell line in lambda gt11 phage to derive molecular cDNA clones representing a putative B lymphocyte - specific octamer binding protein.

«After screening a natural compound library, we developed an unbiased look at combinations of nutrients that have a better effect on prostate cancer than existing drugs,» says corresponding author Stefano Tiziani, assistant professor in the Department of Nutritional Sciences and Dell Pediatric Research Institute at UT Austin.

Typically, pharmaceutical scientists start the discovery process by «screening» large libraries of chemical compounds in search of one or a few that might treat disease.

In one case, the researchers screened a small - molecule compound library and identified compounds that bind tightly to NUCB1, an otherwise little - known protein that showed strong interactions with the arachidonoyl probes.

«And whole libraries may appear on our desktop screens apparently out of thin air, but unless some radical changes are made in the way we design and produce our information age gadgetry, its ecological footprint will never really be reduced.»

They identified AM404 as a potential antiviral agent by screening the National Institutes of Health Clinical Collection, a library of small molecules that have been used clinically in humans, using a high - throughput screening system.

Robotized «high - throughput screens» like this are a growing trend in drug development as they can work through massive libraries of candidate drugs quickly and accurately in a day, as opposed to the months required by manual methods.

Nikolas Jorstad and Matt Wilken, graduate students in Reh's lab, screened a library of small molecules to find one that could reopen access to the genetic code in the adult mouse.

The process of drug discovery has been dominated in recent years by the screening of large libraries of structurally diverse small molecules for effects on target proteins associated with disease.

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«We're now working with our colleagues in Sanford - Burnham's Conrad Prebys Center for Chemical Genomics to screen a large chemical library — a collection of around 300,000 compounds — to find molecules that bind to these newly discovered HNF - 4α sites,» Rastinejad said.

The MSC is a core facility providing the use of high throughput screening technology (HTS), as well as expertise and reagents, necessary for the screening of the library of small molecules for biologically active compounds in a variety of readout systems.

Dr. Rubin said Curis had established a screening assay for SMN levels for a molecular library, first in fibroblasts from an SMA patient.

It has assembled an extensive library of commercially available compounds and natural products that can be screened in seconds using its proprietary Avalanche tool to jumpstart its drug discovery programs.

Dr. Zeng is collaborating with the NIH in a project that would involve the use of a large compound library in the screening efforts.

In addition, RNAi screens are also known to exhibit a high background, which can lead to both false negatives and the need for highly redundant libraries to ensure statistical significance.

Our current works have focused on screening the chemical libraries to identify and further characterize small molecules that can control stem cell fate in various systems.

The discovery of short hairpin RNAs (shRNAs) suppressing gene expression in mammalian cells enables large - scale loss - of - function screens by using genome - wide shRNA libraries.

Roberto Iacone (Anastassiadis, TUD)-- «Lineage commitment screens in mES cells using a tetracycline inducible cDNS library» (2009)

Their goal was to figure out how to optimize protocols for in vivo screening with lentiviral pooled shRNA libraries.

The self - renewable capacity of these cells, their ability to differentiate into several tissue progenitors (neural, mesenchymal stem cells...), and the possibility to work with mutated cell lines define human stem cells as a good basis for screening compounds libraries in order to discover new potential drugs for monogenic diseases.

By early next year, the assay core at Gladstone plans to obtain specialized compound libraries for select high - throughput screening in - house.

lentiCas9 - Blast (Plasmid # 52962) was a gift from Feng Zhang and is described in Improved vectors and genome - wide libraries for CRISPR screening.

Researchers screened a comprehensive library of approved drugs for anti-HCV activity and found a common over-the-counter allergy drug that lowered HCV levels in infected mice.

Used in experiments to understand biological processes and diseases and as part of the initial drug - discovery process, Tocris life science reagents include receptor ligands, ion channel modulators, enzyme inhibitors, caged compounds, fluorescent probes, and screening libraries.

This approach, however, suffers from biases in the library construction and screening which hinders the identification of certain classes of receptors.

After developing and optimizing assays in - house, Gladstone scientists can transfer these assays to the SMDC or other external facilities to perform high - throughput screening with large compound libraries to identify potential drugs that may lead to therapies.

Miralles also credits synthetic chemistry from Baran and Yu, who created a library of covalent fragments that are more complex and chemically diverse than the fragments used in standard screens.

Using this information, we will then take advantage of recent advances in the quantification of assembly to screen candidate small - molecule libraries for enhanced activity in assembly acceleration, inhibition, and misdirection.

Last, the Novartis RIPK2 inhibitor was obtained in a similar manner to GSK583 and was based on a proprietary chemical library screen.

In an early attempt to characterize the expression of the receptor repertoire, Young et al. screened a cDNA library constructed from the olfactory epithelium, using degenerate olfactory receptor probes, and identified the expression of 419 distinct ORs [41].

The 23 libraries treated with damage repair were screened for complexity and endogenous DNA on an Illumina MiSeq platform in Harvard in collaboration with David Reich (Supplementary Table 1).

Targeting intracellular human thymidylate synthase in live cells, their pilot screen identified all drugs within the library known to act on this enzyme.

The bioactivity of the compounds in this library and the ready availability of individual compounds identified as hits for follow - up studies make this library ideal for pilot screenings.

The development of a standardized method to express large panels of P. falciparum cell surface and secreted proteins in their native conformation would enable comprehensive protein libraries to be systematically screened in parallel so that direct comparisons between antigens can be made in functional assays such as vaccine screening and immuno - epidemiology studies.