Sentences with phrase «library screens for»

I found the music library screens for USB drives and iOS devices easy to navigate, but UConnect does not yet include an advanced Bluetooth streaming connection that allows music selection from its touchscreen.

Not exact matches

At 11 a.m., NYC Administration for Children's Services Commissioner David Hansell announces a new partnership with NYU College of Dentistry to provide dental screenings to children in foster care, Nicholas Scoppetta Children's Center, fourth floor library, 492 First Ave., Manhattan.

David Sinclair of Harvard Medical School in Boston and colleagues at the biotech firm BIOMOL Research Laboratories in Plymouth Meeting, Pennsylvania, screened a library of compounds for molecules that trigger SIRT1 activity.

«The next step for us is to utilize these computer models to screen a virtual library of hundreds of thousands of new amines, and identify some new amine candidates predicted to have way better carbon absorption properties.

In 1998, for example, Wiman's team screened a library of 2000 compounds from the U.S. National Cancer Institute and found two that appeared to restore mutant p53's ability to kill cancer cells.

To find new compounds for spraying and nets, IVCC has partnered with several large chemical companies including BASF, Syngenta, and Sumitomo to screen more than 4 million compounds in their libraries.

This work began as part of a biodefense grant from the National Institutes of Health, screening a library of 30,000 compounds for activity against the envelope of Nipah virus, an emerging infection first identified in 1999 in Malaysia.

When researchers screened a library of more than 200 drugs and related compounds for activity against embryonal subtype tumor cells from three patients, the most promising results involved drugs that increased oxidative stress in tumor cells.

They can now take a genome sequence (or many of them) and make a protein library for screening with unprecedented speed, cost - effectiveness and precision, allowing rapid discovery of potentially beneficial biomolecules from a genome.

For instance, it may soon be possible to automatically separate all of the chemicals in an organism, identify them, and catalogue them in a library for future screeniFor instance, it may soon be possible to automatically separate all of the chemicals in an organism, identify them, and catalogue them in a library for future screenifor future screening.

Using a robotics - based screening approach, researchers screened a library of 1,192 FDA - approved drugs for any that suppressed tumors in the fly and identified several that improved overall survival.

Companies in the partnership supply compound libraries and drug discovery expertise to the effort, while academic partners contribute knowledge about the disease and facilities for screens and assays.

The research team plucked seven MERS - specific neutralizing antibodies from the library after using samples of the virus to screen for them.

The researchers created a large library of MphR protein variants and screened them for the ability to switch on production of a fluorescent green protein when they were in the presence of a desired macrolide.

As part of drug discovery, one of the earlier stages is you take a huge library of chemical compounds and you screen them with an assay for malaria or TB and you see if that chemical compound kills the parasite or bacteria.

Specifically, the research team used a miniaturized, high - speed technology to screen through sample libraries of 2,816 compounds already approved by the US Food and Drug Administration for other uses.

With no candidate targets, the team took an objective approach by applying a peptide phage library to MDSCs, which permitted mass screening for candidate peptides — short sequences of amino acids — that bind to the surface of the MDSCs.

Lerner emphasized that this was the first demonstration of screening for the prevention - of - cell - death phenotype using very large antibody libraries — but it won't be the last.

The scientists started with a phenotypic screen, testing their library of compounds for the ability to make young fat cells mature faster and store more fat.

Seeking to exploit this weakness and develop a new class of antifungals, an international group of researchers screened a synthetic drug library for compounds that target the synthesis of fungal but not mammalian GlcCer.

The process of drug discovery has been dominated in recent years by the screening of large libraries of structurally diverse small molecules for effects on target proteins associated with disease.

Such projects involve developing and optimizing assays for automation, screening a large compound library, and characterizing each small - molecule probe.

We are going to screen a larger library of chemicals to identify molecules that either boost or weaken NMD, which should help develop better and more targeted drugs for treating ALS, muscular dystrophy and cystic fibrosis.»

Scientists at the Centers for Disease Control and Prevention (CDC) also contributed by performing initial screening of the Gilead Sciences compound library to find molecules with promising antiviral activity.

«We're now working with our colleagues in Sanford - Burnham's Conrad Prebys Center for Chemical Genomics to screen a large chemical library — a collection of around 300,000 compounds — to find molecules that bind to these newly discovered HNF - 4α sites,» Rastinejad said.

The MSC is a core facility providing the use of high throughput screening technology (HTS), as well as expertise and reagents, necessary for the screening of the library of small molecules for biologically active compounds in a variety of readout systems.

(The test was the perfect complement for one conducted earlier by the Zhang lab for GeCKO, a lentiviral CRISPR library enabling genome - scale, knockout screening).

PsychoGenics leverages its sophisticated Cube technology platforms and broad capabilities to partner with pharmaceutical, biotechnology and not - for - profit research entities to screen diverse compound libraries and discover valuable new therapies for the CNS market.

Dr. Rubin said Curis had established a screening assay for SMN levels for a molecular library, first in fibroblasts from an SMA patient.

The facility maintains a small molecule library of ~ 100,000 drug - like small molecules for high - throughput screening and provides access to liquid handling robotics and a multilabel plate reader.

In addition, RNAi screens are also known to exhibit a high background, which can lead to both false negatives and the need for highly redundant libraries to ensure statistical significance.

UniChem supports the integration of high - throughput screening data on small molecules with chemical libraries and chemical resources for drug discovery and optimization.

The core facility can provide individual shRNA plasmids and cDNA clones for MDACC laboratories, or carry out a screening experiment using the libraries.

The collaboration is based on expanding Pelago's CETSA technology capabilities and will enable screening of large chemical libraries for identification of novel chemical leads with high drug potential.

The identification of disease signatures will enable screens of small molecule libraries to delineate molecular targets that modulate these disease signatures and identify new diagnostic and therapeutic leads for schizophrenia and bipolar disorder.

We have screened a variety of different libraries to obtain new inhibitors for PC1 / 3, PC2 and furin, and have optimized our current leads through chemical modification.

With Jan Stichel at Annette Beck - Sickinger's lab, Leipzig University, Germany and David Weaver, head of the high - throughput screening facilities at Vanderbilt University, I will be screening Vanderbilt's library of small molecules for potential allosteric modulators of the human Y4 receptor.

Improved vectors and genome - wide libraries for CRISPR screening.

Their goal was to figure out how to optimize protocols for in vivo screening with lentiviral pooled shRNA libraries.

Another key contribution made to the field is Schreiber's formal planning of diversity - oriented synthesis (DOS), which involves the creation of diverse libraries of small molecules for biological screening.

Once the Vanderbilt small molecule library has been screened for potential modulators of the Y4 receptor, I will use the results to design efficient and accurate descriptors that can be used with artificial neural networks to predict activity at the Y4 receptor based on a small molecule's structural properties.

The self - renewable capacity of these cells, their ability to differentiate into several tissue progenitors (neural, mesenchymal stem cells...), and the possibility to work with mutated cell lines define human stem cells as a good basis for screening compounds libraries in order to discover new potential drugs for monogenic diseases.

By early next year, the assay core at Gladstone plans to obtain specialized compound libraries for select high - throughput screening in - house.

lentiCas9 - Blast (Plasmid # 52962) was a gift from Feng Zhang and is described in Improved vectors and genome - wide libraries for CRISPR screening.

SapTrap includes a prebuilt donor plasmid library containing several types of fluorescent (EGFP, tagRFP, mCherry) and nonfluorescent (Halo, SNAP) tags, a selectable marker (floxed Cbr - unc - 119) for easy screening of the insertion event, and a variety of connector modules (linker sequences between the tag and homology arms).

Researchers screened a comprehensive library of approved drugs for anti-HCV activity and found a common over-the-counter allergy drug that lowered HCV levels in infected mice.

His previous work at IDRI has included investigations into the physiology of the M.tuberculosis (Mtb) cell wall, the development of an overexpression library for high throughput target identification, and the development of target based high throughput screens for potential drug candidates against Mtb.

The team plans to accomplish this goal by expanding whole genome or exome sequencing for patients, using patient - derived cells to discover new disease mechanisms, and personalized drug library screening.

Using this information, we will then take advantage of recent advances in the quantification of assembly to screen candidate small - molecule libraries for enhanced activity in assembly acceleration, inhibition, and misdirection.

The higher production efficiencies gained by ALiCE ™ will make it possible for biopharmaceutical researchers to detect a significantly higher number of candidates from each DNA library screened, eventually leading to a higher number of viable candidates for development.