To determine whether there was an association between endogenous sex hormones and risk of bone sarcoma, relative risk (RR) of incidence rates and hazard ratios for bone sarcoma were calculated for dogs subdivided on the basis of
lifetime gonadal hormone exposure.
To characterize the dose - response relationship between endogenous sex hormones and bone sarcoma risk, a study providing information on
lifetime gonadal hormone exposure would be required.
Lifetime gonadal hormone exposure of each dog was expressed in terms of total months of gonadal hormone exposure (i.e., number of months sexually intact).
In summary, this study found that male and female Rottweilers with the shortest
lifetime gonadal exposure had the highest risk for bone sarcoma.
Not exact matches
Behavioural risks in male dogs with minimal
lifetime exposure to
gonadal hormones may complicate
These subgroups included two biologically distinct groups representing the extremes of
gonadal hormone exposure (i.e., dogs neutered before skeletal maturation at < 1 year of age and dogs that remained sexually intact for their entire
lifetime).
McGreevy PD, Wilson B, Starling MJ, Serpell JA (2018) Behavioural risks in male dogs with minimal
lifetime exposure to
gonadal hormones may complicate population - control benefits of desexing.