Sentences with phrase «ligand complexes»

This level of observation of either the proteins or protein - ligand complexes makes crystallography one of the most advanced and promising approaches to new drugs discovery.

The fameous «Mohrs salt» is the corresponding Fe + + ammonium ligand complex salt.

Not exact matches

Professor Liddle explained: «The arrangement of ligand groups at metal centres in metal - complexes is crucial to determining their reactivity.

«The arrangement of these ligands is therefore crucial to determining the reactivity of these complexes.

Major histocompatibility complex class II (MHC II) molecules capture peptides within the endocytic pathway to generate T cell receptor (TCR) ligands.

Thus, transport of peptide — MHC II complexes by DCs not only accomplishes transfer from late endocytic compartments to the plasma membrane, but does so in a manner that selectively concentrates TCR ligands and costimulatory molecules for T cell contact.

An approach to an understanding of the electronic structure, geometrical preferences, and reactivity of these complexes may be made if the molecule is «decomposed» conceptually into a metal fragment, MLn, and a ligand.

«We wanted to create better photoluminescent compounds by combining the two previous concepts: the flexibility of the weak aggregation driven complexes and the controllability of the conventional metal - ligand system,» explained Dr. Georgy Filonenko, postdoctoral researcher from the Coordination Chemistry and Catalysis Unit at OIST.

The first method requires a complex ligand, or compound, that strongly binds to a metal ion in a way that would allow for the complex to emit light of certain wavelength.

The ability to tune the wavelength of light emitted from these molecules provides a huge advantage over the traditional metal - ligand PL complexes.»

They prepared a complex with fluoride, tosyl - substituted nitrogen (NHTs), and aryl as well as alkyl carbon ligands, and then measured a ratio of alkyl C - F, C - C, and alkyl C - N bonded products of roughly 5:3:1.

However, this result has not been replicated in vivo, as increasing IL - 15 levels in wild - type experimental animals has not resulted in muscle hypertrophy, suggesting that IL - 15 and IL - 15Rα interactions in vivo may be more complex than simple ligand - receptor binding (11 — 13).

These data clearly demonstrate that the relationship between IL - 15 and IL - 15Rα is more complex than a ligand — membrane - bound receptor interaction, highlighting a unique and, to our knowledge, previously undefined role for IL - 15Rα in muscle physiology and morphology.

Reporting in the journal Nature, Stanley G. Nathenson and his colleague Steven C. Almo, at Albert Einstein College of Medicine, [i] and William S. Somers and colleagues at Wyeth Research in Cambridge, MA, [ii] crystallize and solve the 3D structure of the powerful negative T cell regulatory molecule CTLA - 4 in complex with its ligand B - 7.

The complexes that form between immunophilins and their cognate ligands are the functional modules for immunosuppression.

«These types of ligands had never been applied in catalytic reactions, and the only metal complex we found was made by accident.»

Structure of the Eps15 — stonin2 complex provides a molecular explanation for EH - domain ligand specificity.

A small heterodimerizer ligand is added to link these two domains together, thereby enriching the Cas9 - sgRNA RNP complex into the gesicle.

In bacteria, the ligand - PBP complex develops high affinity for transmembrane proteins such as Trg, and the chimeric Trg - HK protein allows activation of gene expression with one additional protein, a bacterial response regulator [5].

That said, the new complex is unique because those metals are held together without strands of atoms, called ligands.

First, the complex contains a shorter - than - expected metal - metal bond and, as desired, the metals are not supported by bridging ligands.

High quality coating of magnetic silica beads with Steptavidin, Protein A, Protein G or other ligand specific molecules allows isolation of specific target molecules or cells out of large volumes or complex mixtures.

The two CB1 - agonist complexes reveal important conformational changes in the overall structure, relative to the antagonist - bound state, including a 53 % reduction in the volume of the ligand - binding pocket and an increase in the surface area of the G - protein - binding region.

We experimentally developed Trg fusions proteins, which bind the ligand - PBP complex, and activate intracellular PhoR, the HK cognate of PhoB.

Instead, mercury is always paired with a ligand, a molecule or group of molecules that binds to other molecules to form a larger complex.

Appropriate modification of the salphen ligand allows an easy modular design of flexibly linked dimeric salphen species and their complexes, which can act as bifunctional catalysts.

Because iron is extremely scarce in surface seawater, it is thought to occur almost exclusively bound to complex ligands of biological origin.