Sentences with phrase «like effector»

A patent application has been filed and testing is underway on the protein — called HT - TALENs (short for HIV - targeted transcription activator - like effector nucleases)-- which uses a newly developed gene - editing technique to rid the body's cells of the immunodeficiency virus before it has a chance to multiply and possibly develop into AIDS.

Zinc finger nucleases [1], [2], transcription activator - like effector nucleases [3], [4] and homing meganucleases [5] have provided powerful tools to induce targeted mutations in the form of small insertions or deletions derived from DNA break repair of nonhomologous end joining (NHEJ) or homologous recombination.

In a second scheme, transcription activator - like effector nucleases (TALENs) were targeted to sequences near the translation - initiation site of CCHa2 - R to create a frame - shift mutation in the CCHa2 - R coding region [24].

This protocol describes a system for efficient genome editing in hPSCs using engineered transcription activator - like effector nucleases (TALENs) or clustered regularly interspaced short palindromic repeat (CRISPR) technology.

The variety of new tools available for genetic manipulation now include lentiviral - based gene delivery, and gene editing using CRISPR / Cas9, zinc finger nucleases (ZFNs) or transcription activator - like effector nucleases (TALENs).

Science magazine heralded these transcription activator - like effector nuclease proteins, known as TALENS, as a major scientific breakthrough in 2012, nicknaming them «genomic cruise missiles» for their ability to allow researchers to target specific locations with great efficiency.

Another protein - based targeting strategy, TALENs, is based on the transcription activator - like effector (proteins secreted by Xanthomonas bacteria).

Ultimately, this week's discourse will lead to a consensus statement providing some guidance on how to approach using this and older gene editing technologies such as zinc finger nucleases and enzymes called transcription activator - like effector nucleases, or TALENs.

«Before CRISPR, there was TALENS [transcription activator - like effector nucleases] and zinc finger nucleases — older technologies that were not as precise or reliable,» explains Sosa.

Not exact matches

His group showed that a small number of stem - cell like CD8 T cells - called «memory» cells - were enough to produce and repeatedly replenish all of the T - effector cells needed to fight the disease.

After PD - 1 is blocked, these cells divide and differentiate into effector - like cells that migrate to infected tissues.

In their earlier work, the Halle lab already proved that the bacteria introduce numerous harmful proteins, so - called effectors, into plant cells via a specialised secretion system which works like a molecular syringe.

Even though we can not definitively assign these genes an immune effector role, it is apparent that defensin - like peptides have an unusual diversity in Nasonia, representing 18/34 (52.9 %) homology - annotated AMPs and 6/14 (42.9 %) of putative novel AMPs.

Among effectors, 6 of the 18 defensive - like peptides previously annotated are up - regulated upon infection (Figure 3): three of five defensin homologs, and nasonin - 1, -2, and -3.

Based on these sources, we identify 497 genes with possible immune function in Nasonia (Table S1), including 75 encoding effectors (AMPs, proteins in the prophenoloxidase cascade, transferrins, and peroxidases), 96 encoding recognition proteins (including PGRPs, TEPs, Nimrod - like proteins, and numerous lectins), 101 encoding signaling proteins, and 225 encoding proteases or protease inhibitors.