Sentences with phrase «like amyloid»

That we've covered a lot of information here in the article and the last thing that we expect is for you to suddenly become an expert on all of this, we just hope that you'll understand that even with a pre-existing condition like amyloid disease, you may potentially have options, you're just going to need to speak with an agency that knows where to look!

Because we've been doing this awhile here at TermLife2Go, we know that a lot of times when you suffer from a condition like amyloid disease you're not really able to work and may not have a ton of discretionary income, especially if you're currently receiving SSI disability.

Secondly, the blood flushes brain metabolic wastes like amyloid - beta protein released in to the blood vessels of the brain.

Stimulating neurons in the brains with electrodes can keep them active enough to slow down the build - up of toxic neurons like amyloid plaques.

It also clears out intracellular debris and toxins like amyloid plaques and tau tangles.

Two related papers with contributions from Huaxi Xu, Ph.D., the Jeanne and Gary Herberger Chair of Neuroscience and Aging Research at Sanford Burnham Prebys Medical Discovery Institute (SBP), show that a protein called TREM2 helps microglia survive and respond more strongly to damaging material like amyloid and cell debris.

So these new medicines that are being tested are looking at clearing out the accumulation of toxic proteins, like amyloid plaque.

To examine the evolution of the AD - like amyloid pathology we incubated sections with the monoclonal antibody McSA1 [36](MediMabs, Montreal, Canada) at 1:4000 in PBS - T with 5 % NGS overnight at 4 °C.

Correlation between average levels of soluble (a, b) and insoluble (c, d) Aβ42 and Aβ40 and the magnitude of cognitive impairments in transgenic animals, during the temporal progression of the AD - like amyloid pathology.

Temporal progression of the AD - like amyloid pathology in McGill - R - Thy1 - APP transgenic rats.

Taken together, our results demonstrate that the intraneuronal development of AD - like amyloid pathology includes a mixture of molecular species (Aβ, APP and CTFs) of which a considerable component is Aβ; and that the early presence of these species within neurons has deleterious effects in the CNS, even before the development of full - blown AD - like pathology.

Not exact matches

For one, it's made it clear that using tools like PET scans and cerebrospinal fluid testing can help pinpoint which patients have amyloid present in the brain for the treatments to act on.

The pathological amyloid - beta structure is rich in a sticky, sheet - like folding pattern that makes it prone to aggregation, while the healthy structure is not.

They injected tiny amounts of amyloid protein into the brains of the monkeys and found that old Rhesus monkeys developed Alzheimer's - like symptoms but young monkeys stayed healthy.

The structures, called amyloid fibrils, are also implicated in neurodegenerative conditions such as Alzheimer's and Parkinson's, and in prion diseases like Creutzfeldt - Jacob and mad cow disease.

Dogs, for example, develop Alzheimer - like ß - amyloid plaques and symptoms of dementia as they age.

The result, says Flajolet, is a brain that is hard and transparent, almost «like glass,» which allowed the researchers to see the amyloid plaques in full detail and in 3D, in a full mouse brain hemisphere, as well as in small blocks of human brain tissue.

Like cardiovascular disease, Alzheimer's involves the buildup of plaque, in this case tangled beta - amyloid proteins in the brain.

In addition, if ß amyloid does play an important protective role in the brain, it might make sense to treat it more like cholesterol — which is needed by all cells but dangerous in high levels — than something that needs to be completely eliminated, Tanzi says: «Slow it down, yes — but don't wipe it out.»

Scientists have long considered clumps of amyloid plaques — sticky, barnacle - like protein bundles — to be the first sign of Alzheimer's.

«Alzheimer's disease might be a «whole body» problem: Amyloid - beta can travel, cancer - like, to brain from other parts of body.»

To see if these amyloids behave like enzymes, Korendovych and his colleagues made seven simple peptides, each seven amino acids long.

Aducanumab, an antibody made by the pharmaceutical company Biogen, binds to and clears clumps of β amyloid from the brain like many other antibodies that have been tested.

«And it may be time to not latch onto amyloid - beta plaque so much like the field has for a few decades.»

«The amyloid you don't see is like the sugar in your tea that dissolves and hits your taste buds versus the insoluble amyloid, which is more like the sugar that doesn't dissolve and stays at the bottom of the cup.»

A definitive diagnosis of Alzheimer's includes dementia and two distortions in the brain: amyloid plaques, sticky accumulations of misfolded pieces of protein known as amyloid beta peptides; and neurofibrillary tangles, formed when proteins called tau clump into long filaments that twist around each other like ribbons.

b - secretase acts like a pair of molecular scissors, snipping a piece off a large protein to produce b - amyloid, a smaller protein that builds up in plaques in the brains of Alzheimer's patients and is thought to kill neurons.

But in a 2012 study, they found that when they injected synthetic amyloids into lab mice bred to have an MS - like brain inflammation, the mice got better and were able to walk again.

Amyloid plaques, a hallmark of diseases like Alzheimer's, may have catalysed life's metabolic reactions billions of years ago, long before enzymes appeared

Scientists already had hints that the protein in question, amyloid - beta, behaves like an infectious prion, a misshapen protein that coaxes other proteins to misfold and spread from cell to cell.

When Cramer gave bexarotene to mice with Alzheimer's - like damage, more than half of the beta - amyloid plaques cleared from the brain within 72 hours.

Some scientists do not like to use the word «prion» in connection with the amyloids associated with common neurodegenerative diseases, or to describe any of their properties as «prion - like» — because of its connotation of infectious, deadly disease.

Like other pathologists in countries where people had died of CJD associated with medical procedures, he rushed to check the centre's archives of autopsied brains to see if any of them contained the ominous amyloid deposits.

«I think that controlling one's amyloid β is likely to be a lifelong endeavor just like controlling one's cholesterol,» Gandy says.

Amyloids stick like glue to metal surgical instruments, and normal sterilization does not remove them, so amyloid seeds might possibly be transferred during surgery.

Researchers are also trying to work out what the putative amyloid seeds look like, and whether different «strains» of amyloids exist that are particularly damaging.

Amyloid protein causes diseases like Alzheimer's, Parkinson's and Creutzfeldt - Jakob disease.

The main part of the beta - amyloid 1 - 42 peptide is shaped like a double horseshoe.

Male homozygous mice for hIAPP develop T2D - like clinical and pathologic alterations, including hyperglycemia, reduced insulin secretion, IAPP amyloid deposits, and β cell loss (Janson et al., 1996).

Like humans with AD, hAPP mice have elevated levels of amyloid β (Aβ) peptides in the brain, network and synaptic dysfunction, and amyloid plaques (9).

In the lab, protein amyloids, like those that clog up the brains of people who died from Alzheimer's disease, are impervious to just about anything, including extreme heat and cold and powerful detergents.

To conduct key experiments supporting the prion - like properties of amyloid - beta, Walker has been collaborating with Matthias Jucker in TÃ 1/4 bingen, Germany and spent four months there on a sabbatical last year.

Musen would like to employ amyloid imaging in type 2 diabetic patients to determine whether amyloid deposits are present in their brains.

During these years, she focused on the structural properties of the amyloid - like oligomeric intermediates formed by the bacterial HypF - N protein under different solution conditions, mainly using the Förster Resonance Energy Transfer (FRET) technique.

Although genetic deletion of BACE1 results in abolished amyloid pathology in AD model mice, it also results in neurodevelopmental phenotypes such as hypomyelination and synaptic loss, observed in schizophrenia and autism - like phenotype.

Amyloid fibers, those clumps of plaque - like proteins that clog up the brains of Alzheimer's patients, have perplexed scientists with their robust structures.

Collinge admitted that more research needs to be done to fully understand how important a pathway the amyloid seeds might be in contributing to Alzheimer's, but that the latest results highlight «the growing paradigm shift in understanding that neurodegenerative disease [like Alzheimer's and Parkinson's] may be all about accumulation of [prion] seeds.»

Reduced metabolic activity of brain cells and neurons means less brain activity and a decreased ability of the brain to clear abnormal structures like the beta - amyloid plaques associated with Alzheimer's disease.

What I would like to address, though, is how we can clinically address the under - appreciated role of microflora - derived amyloid in contributing to the development of AD.

To do so I would like to return to my discussion of the paper «Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease» by Pistollato et al (2).