Not exact matches
The result, says Flajolet, is a
brain that is hard and transparent, almost «
like glass,» which allowed the researchers to see the amyloid
plaques in full detail and in 3D, in a full mouse
brain hemisphere, as well as in small blocks of human
brain tissue.
Like cardiovascular disease, Alzheimer's involves the buildup of
plaque, in this case tangled beta - amyloid proteins in the
brain.
We get heavily hyped drugs
like Avastin, which shrank tumors without adding significant time to cancer patients» lives (and increased the incidence of heart failure and blood clots to boot); Avandia, which lowered blood sugar in diabetics but raised the average risk of heart attack by 43 percent; torcetrapib, which raised both good cholesterol and death rates; and Flurizan, which reduced
brain plaque but failed to slow the cognitive ravages of Alzheimer's disease before trials were finally halted in 2008.
A definitive diagnosis of Alzheimer's includes dementia and two distortions in the
brain: amyloid
plaques, sticky accumulations of misfolded pieces of protein known as amyloid beta peptides; and neurofibrillary tangles, formed when proteins called tau clump into long filaments that twist around each other
like ribbons.
b - secretase acts
like a pair of molecular scissors, snipping a piece off a large protein to produce b - amyloid, a smaller protein that builds up in
plaques in the
brains of Alzheimer's patients and is thought to kill neurons.
When Cramer gave bexarotene to mice with Alzheimer's -
like damage, more than half of the beta - amyloid
plaques cleared from the
brain within 72 hours.
Like humans with AD, hAPP mice have elevated levels of amyloid β (Aβ) peptides in the
brain, network and synaptic dysfunction, and amyloid
plaques (9).
Stimulating neurons in the
brains with electrodes can keep them active enough to slow down the build - up of toxic neurons
like amyloid
plaques.
Amyloid fibers, those clumps of
plaque -
like proteins that clog up the
brains of Alzheimer's patients, have perplexed scientists with their robust structures.
Reduced metabolic activity of
brain cells and neurons means less
brain activity and a decreased ability of the
brain to clear abnormal structures
like the beta - amyloid
plaques associated with Alzheimer's disease.
Food for heart and
brain: Antioxidants
like anthocyanin, prevents the buildup of
plaque in arteries and is capable of controlling cholesterol levels.
A study done at UC Davis found that E. coli and salmonella bacteria in mice produce fiber -
like structures very similar to the inflammatory
brain plaques seen in people with Alzheimer's disease2.
Interestingly, according to Dr. Stern, this is the same gene mutation that has been linked to the development of
plaque -
like lesions in the
brains of Alzheimer's sufferers.