Sentences with phrase «like cell cycle»

Significantly, treatment with 6AN specifically decreased the activity of genes with malignant, cancer - spreading functions, like cell cycle control and DNA repair.

Not exact matches

But in disease conditions like muscular dystrophies, satellite cells can't keep up with repeated cycles of injury and are ultimately exhausted or functionally impaired,» Hindi said.

Upon joining the lab, Lee chose a high - risk project — «it sounded like more fun,» she says — aimed at determining whether a key gene in the yeast cell cycle, cdc2, was also present in human cells.

It also undergoes cell division by first creating copies of chromosomes like most human cells and has a very fast replication cycle, all of which facilitated the study.

Like animals, individual cells proceed through a life cycle.

They found that like bacteria and budding yeast, H. salinarum controls its size by adding a constant volume between two events in the cell cycle.

Here, we show that a non-adherent, stem - like, and metastatic CSC - enriched subpopulation could be isolated by exposing human metastatic breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.

In our study, we found that exposing metastatic breast cancer cell lines to hypoxia and reoxygenation cycles induces a unique subpopulation that is highly metastatic and exhibits stem - like and EMT phenotypes.

The team found that p75NTR production, like the circadian clock genes themselves, oscillated in a 24 - hour cycle — in sync with the cells» natural circadian rhythm.

In our study, we found that the emergence of a small non-adherent subpopulation (approximately 1 %) survived after the first hypoxia / reoxygenation cycle and speculate that cyclic exposures of hypoxia and reoxygenation may select for the stem - like subpopulation with the ability to overcome replication arrest whereas the majority of non-adherent cells can not.

Two newly synthesized 5 - methyltetrahydrofolate - like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1 / S phase and apoptosis in vitro.

Furthermore, we found that the stem - like and EMT phenotypes observed in the cycling hypoxia - selected subpopulation are not reversible, because we obtained the same molecular profile from this subpopulation by culturing them as spherical cultures for several months in normal oxygen content and culturing them as adherent cells (Figure S2 in Additional file 2).

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Like in the Wnt signaling pathway, ligands bind to the EGFR on the cell surface and initiate a cascade of events in the cell that in this case lead to regulation of genes that control cell cycle progression.

Polo - like kinase 1 (PLK1), a critical cell cycle regulator, has been identified as a potential target in osteosarcoma (OS).

58/4: 15 Neuronal aneuploidy and associated apoptosis in familial and sporadic frontotemporal lobar degeneration indicate that FTLD, like Alzheimer's disease and Niemann - Pick C1, is a cell cycle disorder.

They act like a «molecular clock» and become shorter with every cycle of cell reproduction.

FIVE diagrams are included: • Cellular Respiration Equation • Cellular Respiration Overview • Glycolysis • Krebs Cycle • Electron Transport Chain NGSS Alignment: HS - LS1 - 7, HS - LS2 - 5 Key Terms Include: • acetyl coenzyme A • ADP • adenosine triphosphate, ATP • ATP synthase • carbon dioxide • chemiosmosis • electron transport chain • FADH2 • glucose • glycolysis • H + ions • Krebs cycle • NADH • parts of the mitochondrion • pyruvic acid You might also like my: • Cellular Respiration PowerPoint and Notes: https://www.tes.com/us/teacher-lessons/cellular-respiration-powerpoint-and-notes-11133202 • Cellular Respiration Task Cards: https://www.tes.com/us/teacher-lessons/cellular-respiration-task-cards-with-powerpoint-review-11133254 • Cells Unit Bundle: https://www.tes.com/us/teacher-lessons/cells-bundle-powerpoints-notes-and-task-cards-11139453 Happy TeacCycle • Electron Transport Chain NGSS Alignment: HS - LS1 - 7, HS - LS2 - 5 Key Terms Include: • acetyl coenzyme A • ADP • adenosine triphosphate, ATP • ATP synthase • carbon dioxide • chemiosmosis • electron transport chain • FADH2 • glucose • glycolysis • H + ions • Krebs cycle • NADH • parts of the mitochondrion • pyruvic acid You might also like my: • Cellular Respiration PowerPoint and Notes: https://www.tes.com/us/teacher-lessons/cellular-respiration-powerpoint-and-notes-11133202 • Cellular Respiration Task Cards: https://www.tes.com/us/teacher-lessons/cellular-respiration-task-cards-with-powerpoint-review-11133254 • Cells Unit Bundle: https://www.tes.com/us/teacher-lessons/cells-bundle-powerpoints-notes-and-task-cards-11139453 Happy Teaccycle • NADH • parts of the mitochondrion • pyruvic acid You might also like my: • Cellular Respiration PowerPoint and Notes: https://www.tes.com/us/teacher-lessons/cellular-respiration-powerpoint-and-notes-11133202 • Cellular Respiration Task Cards: https://www.tes.com/us/teacher-lessons/cellular-respiration-task-cards-with-powerpoint-review-11133254 • Cells Unit Bundle: https://www.tes.com/us/teacher-lessons/cells-bundle-powerpoints-notes-and-task-cards-11139453 Happy Teaching!

Working on the PCV is important, many factors go into red blood cell production starting with a hormone secreted by the kidneys called erythropoietin (you hear about it a lot in sports like cycling) which stimulates red blood cell production; more investigation may be needed to determine if the problem is an increase in destruction or a decrease in production.

And with a release cycle every year to every two years, gamers would have the ability to refresh their console with new features, new hardware, and new functionality just like smartphone users are able to do with their cell phones.

Seems unlikely to make much difference over large scale averages but wouldn't this be a potential problem for accurate reproduction of more intricate details like seasonal or diurnal cycles in individual grid cells or regions?

If driving a car around a city can feel like being trapped in your own personal, (slowly) mobile prison cell, then on a good day cycling is more like cantering along a prairie.»

We had to ride south on Avenue Road, keeping as close to the curb as possible on one of the busiest streets in town in the middle of rush hour, wondering what kind of governments hypocritically promote cycling and then neglect to provide any decent routes; that refuse to demand sideguards on trucks like they do in the UK; that refuse to enforce the few rules about parking or driving in bike lanes; and that refuse to ban cell phone use while driving when 80 % of accidents are caused by inattention of drivers.