Metabolic acidosis is a mild condition resulting from increased acid production from metabolism or reduced excretion of stomach acids that could be caused by underlying conditions
like diabetic ketoacidosis, renal failure, or respiratory dysfunction.
We would
like to emphasize that ketosis is a completely physiological mechanism and it was the biochemist Hans Krebs who first referred to physiological ketosis to differentiate it from the pathological keto acidosis seen in type 1 diabetes.8 In physiological ketosis (which occurs during very - low - calorie ketogenic diets), ketonemia reaches maximum levels of 7/8 mmol / l (it does not go higher precisely because the CNS efficiently uses these molecules for energy in place of glucose) and with no change in pH, whereas in uncontrolled
diabetic ketoacidosis it can exceed 20 mmol / l with a concomitant lowering of blood pH9, 10 (Table 1).