«Just
like human breast cancer, there are many subtypes that can be found in mice,» said Eran Andrechek, co-author and physiology professor whose work focuses on the genetic makeup of cancer.
Not exact matches
She says animals are following similar health patterns as
humans,
like how around one out of eight females of either species gets
breast cancer.
Human breast cancers can be classified according to their histological and molecular features into different subtypes, including luminal, ERBB2 and basal -
like tumors.
Moreover, epalrestat, a drug that inhibits AKR1B1 and is approved in Japan to treat peripheral neuropathies associated with diabetes, was similarly able to block the growth and metastasis of
human basal -
like breast cancer cells.
Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with
human basal -
like breast cancer cells.
She expects she will find laminum - 8 uniquely overexpressed in other invasive
cancers,
like lung and colon
cancer, but to date she has tested for it in only
human brain and metastatic
breast cancer.
«There are still many questions left to answer but we now know that oxygen poor environments,
like those often found in advanced
human breast cancers serve as nurseries for the birth of
cancer stem cells,» says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine and a member of the Johns Hopkins Kimmel Cancer C
cancer stem cells,» says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine and a member of the Johns Hopkins Kimmel
Cancer C
Cancer Center.
The title of the paper is «Bioinformatic analysis reveals a pattern of STAT3 - associated gene expression specific to basal -
like breast cancers in
human tumors.»
Some experts have traced estrogen -
like chemicals to increased rates of
human breast cancer, and there is even more evidence that they endanger animals by feminizing the sex organs of male frogs and fish living downstream from sewage treatment plants.
Here, we show that a non-adherent, stem -
like, and metastatic CSC - enriched subpopulation could be isolated by exposing
human metastatic
breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.
Aug 8, 2008 Two New Predisposition Genes For
Breast, Thyroid And Kidney
Cancers Could Lead to More Accurate Diagnosis and Earlier Detection of These
Cancers Charis Eng, MD, PhD, Sondra J and Stephen R Hardis Endowed Chair of
Cancer Genomic Medicine and Chair, GMI, and her team published in the Aug 8, 2008 issue of the American Journal of
Human Genetics that germline mutations in SDHB and SDHD, which play key roles in the mitochondria (the cell's power houses), predispose to Cowden and Cowden -
like syndromes.
Should collaborations
like these prove to be important also in
human breast cancer, disrupting key interactions may be a novel treatment strategy for the disease.
There is also now abundant research that links BPA and phthalate exposure to such
human health concerns as deformities of the male and female genitals; premature puberty in females; decreased sperm quality; and increases in
breast and prostate
cancers, infertility, miscarriages, obesity, type 2 diabetes, allergies and neurological problems,
like attention deficit hyperactivity disorder.
Although no specific dosage for
humans has been determined yet, it seems that maintaining a minimal amount of apigenin in the bloodstream is beneficial for delaying the onset of
breast cancer which progresses as a result of progestins
like MPA.
Like cancer in
humans,
cancer in pets can be found in the bones, skin, head,
breast, neck, testicles, abdomen and lymph system, and will likely spread throughout the body's organs in a similar manner to
human cancer.
Yes, male dogs, just
like male
humans, can get
breast cancer, and usually it has a worse prognosis in males than in females.